ID   LMO4_BOVIN              Reviewed;         165 AA.
AC   Q3SWZ8;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   24-JAN-2024, entry version 110.
DE   RecName: Full=LIM domain transcription factor LMO4;
DE   AltName: Full=LIM domain only protein 4;
DE            Short=LMO-4;
GN   Name=LMO4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription cofactor. Plays a role in establishing motor
CC       neuron identity, in concert with MNX1, acting, at least in part, to
CC       disrupt LDB1-LHX3 complexes thereby negatively modulating interneuron
CC       genes in motor neurons. {ECO:0000250|UniProtKB:P61969}.
CC   -!- SUBUNIT: Interacts strongly with LDBS. Interacts with LDB2 and LDB1.
CC       Interaction with complexes consisting of at least LDB1 and LHX3 acts to
CC       disassemble the complex; may preferentially disassemble LDB1-LHX3
CC       complexes rather than complexes consisting of LDB1, LHX3 and ISL1.
CC       Interacts (via the LIM zinc-binding domain 1) with RBBP8. Interacts
CC       with both RPPB8 and LDB1 through the same face and cannot bind to both
CC       proteins simultaneously. Interacts with BRCA1 (via the BRCT domains);
CC       the interaction represses BRCA1 transcriptional activity. Interacts
CC       with DEAF1; LMO4 blocks export from nucleus.
CC       {ECO:0000250|UniProtKB:P61969}.
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DR   EMBL; BC104582; AAI04583.1; -; mRNA.
DR   RefSeq; NP_001029923.1; NM_001034751.1.
DR   AlphaFoldDB; Q3SWZ8; -.
DR   BMRB; Q3SWZ8; -.
DR   SMR; Q3SWZ8; -.
DR   STRING; 9913.ENSBTAP00000070402; -.
DR   PaxDb; 9913-ENSBTAP00000000389; -.
DR   Ensembl; ENSBTAT00000000389.6; ENSBTAP00000000389.5; ENSBTAG00000000305.6.
DR   GeneID; 614212; -.
DR   KEGG; bta:614212; -.
DR   CTD; 8543; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000305; -.
DR   VGNC; VGNC:30936; LMO4.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00940000157730; -.
DR   HOGENOM; CLU_001357_7_1_1; -.
DR   InParanoid; Q3SWZ8; -.
DR   OMA; WINGITP; -.
DR   OrthoDB; 2875464at2759; -.
DR   TreeFam; TF351071; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000000305; Expressed in occipital lobe and 103 other cell types or tissues.
DR   ExpressionAtlas; Q3SWZ8; baseline and differential.
DR   GO; GO:0031252; C:cell leading edge; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0001843; P:neural tube closure; ISS:UniProtKB.
DR   GO; GO:0033674; P:positive regulation of kinase activity; ISS:UniProtKB.
DR   GO; GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
DR   CDD; cd09386; LIM1_LMO4; 1.
DR   CDD; cd09387; LIM2_LMO4; 1.
DR   Gene3D; 2.10.110.10; Cysteine Rich Protein; 2.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR45787; LD11652P; 1.
DR   PANTHER; PTHR45787:SF5; LIM DOMAIN TRANSCRIPTION FACTOR LMO4; 1.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00132; LIM; 2.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 4.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   LIM domain; Metal-binding; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..165
FT                   /note="LIM domain transcription factor LMO4"
FT                   /id="PRO_0000265108"
FT   DOMAIN          23..83
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          87..147
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
SQ   SEQUENCE   165 AA;  17994 MW;  C8AC295144AD7787 CRC64;
     MVNPGSSSQP PPVTAGSLSW KRCAGCGGKI ADRFLLYAMD SYWHSRCLKC SCCQAQLGDI
     GTSCYTKSGM ILCRNDYIRL FGNSGACSAC GQSIPASELV MRAQGNVYHL KCFTCSTCRN
     RLVPGDRFHY INGSLFCEHD RPTALINGHL NSLQSNPLLP DQKVC
//