ID LYTH_STAS1 Reviewed; 291 AA.
AC Q49Y70;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE RecName: Full=Probable cell wall amidase LytH;
DE EC=3.5.1.-;
DE Flags: Precursor;
GN Name=lytH; OrderedLocusNames=SSP1127;
OS Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS 20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=342451;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT pathogenesis of uncomplicated urinary tract infection.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC -!- FUNCTION: Probably involved in cell-wall metabolism. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family.
CC {ECO:0000305}.
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DR EMBL; AP008934; BAE18272.1; -; Genomic_DNA.
DR RefSeq; WP_011302955.1; NZ_MTGA01000038.1.
DR AlphaFoldDB; Q49Y70; -.
DR SMR; Q49Y70; -.
DR KEGG; ssp:SSP1127; -.
DR PATRIC; fig|342451.11.peg.1127; -.
DR eggNOG; COG0860; Bacteria.
DR HOGENOM; CLU_014322_1_1_9; -.
DR OrthoDB; 9806267at2; -.
DR Proteomes; UP000006371; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:InterPro.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR CDD; cd02696; MurNAc-LAA; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 3.40.630.40; Zn-dependent exopeptidases; 1.
DR InterPro; IPR017273; LytH.
DR InterPro; IPR002508; MurNAc-LAA_cat.
DR InterPro; IPR003646; SH3-like_bac-type.
DR PANTHER; PTHR30404; N-ACETYLMURAMOYL-L-ALANINE AMIDASE; 1.
DR PANTHER; PTHR30404:SF0; N-ACETYLMURAMOYL-L-ALANINE AMIDASE AMIC; 1.
DR Pfam; PF01520; Amidase_3; 1.
DR Pfam; PF08239; SH3_3; 1.
DR PIRSF; PIRSF037730; CWA_LytH_prd; 1.
DR SMART; SM00646; Ami_3; 1.
DR SMART; SM00287; SH3b; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS51781; SH3B; 1.
PE 3: Inferred from homology;
KW Cell wall biogenesis/degradation; Hydrolase; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..40
FT /evidence="ECO:0000255"
FT CHAIN 41..291
FT /note="Probable cell wall amidase LytH"
FT /id="PRO_0000226289"
FT DOMAIN 41..105
FT /note="SH3b"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01117"
FT DOMAIN 122..286
FT /note="MurNAc-LAA"
FT /evidence="ECO:0000255"
FT REGION 109..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 291 AA; 32627 MW; 429A97F588CF3796 CRC64;
MKKFNDWLEK HNLRNIPTLI VVVAFVLFVF MTIAFLNHND EDSSTIYITE DAELRTGPSA
AYPEIHSIDK GQNFHKIGKT GKWIEVVSSN NKEKGWVAGW HTNLNIQADK NPNAKPLKDK
TIVLDPGHGG SDQGASSNTH KKSKEKVYTL KTAKELKALL EKEGATVSMT RESDTYVTLD
DRNIKGDAYI SIHNDSLKSS KANGSTVYWF KDNQKALAET LSASLQKKAL LTNKGARQEN
FQVLRQTNVP AVLLELGYIS NPTDEDMITE KLHRHIVEQA IVEGLRAYFS E
//
