ID M0C2S5_9EURY Unreviewed; 447 AA.
AC M0C2S5;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=isochorismate synthase {ECO:0000256|ARBA:ARBA00012824};
DE EC=5.4.4.2 {ECO:0000256|ARBA:ARBA00012824};
DE AltName: Full=Isochorismate mutase {ECO:0000256|ARBA:ARBA00041564};
GN ORFNames=C476_14933 {ECO:0000313|EMBL:ELZ17581.1};
OS Natrinema limicola JCM 13563.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natrinema.
OX NCBI_TaxID=1230457 {ECO:0000313|EMBL:ELZ17581.1, ECO:0000313|Proteomes:UP000011615};
RN [1] {ECO:0000313|EMBL:ELZ17581.1, ECO:0000313|Proteomes:UP000011615}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 13563 {ECO:0000313|EMBL:ELZ17581.1,
RC ECO:0000313|Proteomes:UP000011615};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000799};
CC -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC {ECO:0000256|ARBA:ARBA00005297}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELZ17581.1}.
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DR EMBL; AOIT01000059; ELZ17581.1; -; Genomic_DNA.
DR RefSeq; WP_008014348.1; NZ_AOIT01000059.1.
DR AlphaFoldDB; M0C2S5; -.
DR STRING; 1230457.C476_14933; -.
DR PATRIC; fig|1230457.4.peg.3001; -.
DR eggNOG; arCOG02015; Archaea.
DR OrthoDB; 195185at2157; -.
DR UniPathway; UPA00035; UER00040.
DR Proteomes; UP000011615; Unassembled WGS sequence.
DR GO; GO:0008909; F:isochorismate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR004561; IsoChor_synthase.
DR NCBIfam; TIGR00543; isochor_syn; 1.
DR PANTHER; PTHR42839; ISOCHORISMATE SYNTHASE ENTC; 1.
DR PANTHER; PTHR42839:SF1; ISOCHORISMATE SYNTHASE MENF; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000011615}.
FT DOMAIN 185..438
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
FT REGION 164..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 48935 MW; FB16BA8BF36BB433 CRC64;
MDRSSGEGRL TGETESVDNA VDLVSRSREL ETAAFDAVLE DETASRIQWA TPDGLEIVGR
GVAARFTATG TDRFDRIRTQ ASRAFNGLAH DGPEHARPRA FGGFSFHDGH EAGPPWTGFD
AASFVVPQLF VTRTDDGTWL TAVGEHSDTV ADRLERWHDR LTNQPATRPA DATPGVAATR
RTTSQTAWTE QVDTALERIA DGQLTKVVLA QSLSVDLEEP IDVPATLERL RRRYPNCYGF
LVDHDIGGTF FGAPPERLVS KRGACVETEA LAGSVPRGET PAEDEAHVDR MRDDPKFQRE
HGLVVDAIRE QLAPLARDLT VSEQTIRRLA TIQHLRTPIE ATLEGEHHVL ELVEALHPTP
AVGGVPPDAA WETIRDTEPF DRGWYAAPVG WFDAAGDGEF AVGLRSGVAA DETVTLFAGN
GIVADSDPDE EWDEVQLKFR PILDELR
//
