ID M0CYK4_9EURY Unreviewed; 339 AA.
AC M0CYK4;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Alcohol dehydrogenase zinc-binding domain protein {ECO:0000313|EMBL:ELZ27492.1};
GN ORFNames=C475_06220 {ECO:0000313|EMBL:ELZ27492.1};
OS Halosimplex carlsbadense 2-9-1.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Halosimplex.
OX NCBI_TaxID=797114 {ECO:0000313|EMBL:ELZ27492.1, ECO:0000313|Proteomes:UP000011626};
RN [1] {ECO:0000313|EMBL:ELZ27492.1, ECO:0000313|Proteomes:UP000011626}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2-9-1 {ECO:0000313|EMBL:ELZ27492.1,
RC ECO:0000313|Proteomes:UP000011626};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELZ27492.1}.
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DR EMBL; AOIU01000013; ELZ27492.1; -; Genomic_DNA.
DR RefSeq; WP_006882916.1; NZ_AOIU01000013.1.
DR AlphaFoldDB; M0CYK4; -.
DR STRING; 797114.C475_06220; -.
DR PATRIC; fig|797114.5.peg.1273; -.
DR eggNOG; arCOG01461; Archaea.
DR OrthoDB; 10249at2157; -.
DR Proteomes; UP000011626; Unassembled WGS sequence.
DR GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05288; PGDH; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR041694; ADH_N_2.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR045010; MDR_fam.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1.
DR PANTHER; PTHR43205:SF7; PROSTAGLANDIN REDUCTASE 1; 1.
DR Pfam; PF16884; ADH_N_2; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000011626}.
FT DOMAIN 19..332
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 339 AA; 35695 MW; 78753CDE9DA94F77 CRC64;
MRDTNRQFRL AKRPEGKPDR DTFDLVETDV PEPAPGEALV RTRYLSVDPY MRGRMSAAES
YADPWEVGDP LQGGVVGEVV ESNGAGFEAG DIVTGNLRWA DYAAAPGTAL REVDPDLGPV
STALGVLGMP GRTAYFGVRE VAEPGPGDTF VVTGAAGAVG SVAGQIANLA GARVVGFAGS
AEKVAFLEDE LGFDAGIDYS ATDDYGAALD EAAPDGVDAY FDNVGGPITD AVFDRLNVDA
RVAVCGQISL YNATERPTGP RKLPGLVSKR ARVEGFLVGD FAPRFEAATG RLAEWVARGD
LQYRETVTEG LESAPEAFLG LFEGENIGKQ LVRVSDPDA
//
