ID M0M5Z1_HALMO Unreviewed; 558 AA.
AC M0M5Z1;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=NADH dehydrogenase/oxidoreductase {ECO:0000313|EMBL:EMA39800.1};
GN ORFNames=C448_14378 {ECO:0000313|EMBL:EMA39800.1};
OS Halococcus morrhuae DSM 1307.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halococcaceae; Halococcus.
OX NCBI_TaxID=931277 {ECO:0000313|EMBL:EMA39800.1, ECO:0000313|Proteomes:UP000011568};
RN [1] {ECO:0000313|EMBL:EMA39800.1, ECO:0000313|Proteomes:UP000011568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1307 {ECO:0000313|EMBL:EMA39800.1,
RC ECO:0000313|Proteomes:UP000011568};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:57888, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124;
CC Evidence={ECO:0000256|ARBA:ARBA00000100};
CC -!- SUBUNIT: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD,
CC E, F, and G constitute the peripheral sector of the complex.
CC {ECO:0000256|ARBA:ARBA00038617}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the complex I 49 kDa
CC subunit family. {ECO:0000256|ARBA:ARBA00010019}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMA39800.1}.
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DR EMBL; AOMC01000156; EMA39800.1; -; Genomic_DNA.
DR RefSeq; WP_004055794.1; NZ_AOMC01000156.1.
DR AlphaFoldDB; M0M5Z1; -.
DR STRING; 931277.C448_14378; -.
DR PATRIC; fig|931277.6.peg.2821; -.
DR eggNOG; arCOG01548; Archaea.
DR OrthoDB; 43567at2157; -.
DR Proteomes; UP000011568; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR Gene3D; 1.10.645.10; Cytochrome-c3 Hydrogenase, chain B; 1.
DR Gene3D; 3.30.460.80; NADH:ubiquinone oxidoreductase, 30kDa subunit; 1.
DR HAMAP; MF_01358; NDH1_NuoD; 1.
DR InterPro; IPR001135; NADH_Q_OxRdtase_suD.
DR InterPro; IPR037232; NADH_quin_OxRdtase_su_C/D-like.
DR InterPro; IPR001268; NADH_UbQ_OxRdtase_30kDa_su.
DR InterPro; IPR020396; NADH_UbQ_OxRdtase_CS.
DR InterPro; IPR022885; NDH1_su_D/H.
DR InterPro; IPR029014; NiFe-Hase_large.
DR PANTHER; PTHR11993:SF10; NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11993; NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT; 1.
DR Pfam; PF00329; Complex1_30kDa; 1.
DR Pfam; PF00346; Complex1_49kDa; 1.
DR SUPFAM; SSF56762; HydB/Nqo4-like; 1.
DR SUPFAM; SSF143243; Nqo5-like; 1.
DR PROSITE; PS00542; COMPLEX1_30K; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Reference proteome {ECO:0000313|Proteomes:UP000011568}.
FT DOMAIN 46..163
FT /note="NADH:ubiquinone oxidoreductase 30kDa subunit"
FT /evidence="ECO:0000259|Pfam:PF00329"
FT DOMAIN 308..558
FT /note="NADH-quinone oxidoreductase subunit D"
FT /evidence="ECO:0000259|Pfam:PF00346"
SQ SEQUENCE 558 AA; 63512 MW; 99368B27060F4348 CRC64;
MSLERPTDRT DTVGVTEEGL DYDALADLLG DRVVSREQHH HTEAFTIRPD EVQDVLFALR
DQAGFDHCSN VTAQEYENRF ETIYHLKKYA DPTQELSVVV PTSKDNPVSE SAEPVYRTAD
WHEREAYDLV GIQYEGHPDM RRILLPETWK GHPMGLDYNQ EKPQIVTLEA HANPLEDDEH
DAGADTMYLN IGPHHPATHG VLHIETVLDG EQVAHVEPDI GYLHRCEEQM AQQGTYRHEI
MPYPDRWDYV SAGILNEWAY ARTAEELTDL DVPDYAQVIR TMSAELCRIA AHMLAVGTFA
LDVYGEFTAT FMYAFRDREV VENILEDLTG QRLMFNYLRL GGVAWDLPEP REAFFEKIRD
FLDGLPHKLD EYHDLLTSNE IFQLRCANTG VLDAETAKQY GATGPVARAS GVDYDIRRDD
PYGYYPELDW DVVTAEEGDN YARVLCRLQE VEESARIIDQ CVDLLEDWPE DDREIQSNVP
RTLRPDDDAE IYRAVEGAKG ELGIYIRSDG TDKPARFKIR SPAFSNLQTL PELAVGEYVP
DLIASLASLD IVLGEVDR
//
