ID M0ME71_HALMO Unreviewed; 556 AA.
AC M0ME71;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Na+/H+ antiporter {ECO:0000313|EMBL:EMA42974.1};
GN ORFNames=C448_10057 {ECO:0000313|EMBL:EMA42974.1};
OS Halococcus morrhuae DSM 1307.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halococcaceae; Halococcus.
OX NCBI_TaxID=931277 {ECO:0000313|EMBL:EMA42974.1, ECO:0000313|Proteomes:UP000011568};
RN [1] {ECO:0000313|EMBL:EMA42974.1, ECO:0000313|Proteomes:UP000011568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1307 {ECO:0000313|EMBL:EMA42974.1,
RC ECO:0000313|Proteomes:UP000011568};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMA42974.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AOMC01000123; EMA42974.1; -; Genomic_DNA.
DR RefSeq; WP_004054347.1; NZ_AOMC01000123.1.
DR AlphaFoldDB; M0ME71; -.
DR STRING; 931277.C448_10057; -.
DR PATRIC; fig|931277.6.peg.1965; -.
DR eggNOG; arCOG02009; Archaea.
DR OrthoDB; 76879at2157; -.
DR Proteomes; UP000011568; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR PANTHER; PTHR43478; NA+/H+ ANTIPORTER-RELATED; 1.
DR PANTHER; PTHR43478:SF1; NA_H_ANTIPORTER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011568};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 30..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 526..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 237..545
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 556 AA; 58177 MW; 905758CEA826F66D CRC64;
MPLESIAAGP WALVPALLAI SLAWYVRDAL IGLFVGIAGG AVVYGLFRPE VVGVPPGLDG
PLGTLLGGLL GITVIPELVA TSPLFADPWY VKNVLLALFA IGGLMGLMIR AGAIRGVLEA
LASRVESPAD AEKASFLAGI IIHIDDYFNC LVVGSMMRPL TDEHDVSRAK LAYYVDSAGS
PAARLAFYST WGVALVGFIG AGITAAAKQN VLPAGMSGYV TQTGDGLQAA TDAVWPLFFN
TLGFAFYSWV ALVVAALVAW QVLPNIFEMG EEEERARNGG GVVGPDDDPL VSDEMANYEM
YEGATPDWRN FAIPVLTIVG IGLLAMFWRS SPVLNAPQTT SVVSAFGYEL LVPAGGPWSL
NIGEIRLGLA SMMGLLVGFV LFRVRGDIPS NGDATDAMIN GFKGIFLAAA ILTLAITIQN
TVSTLGISSF VTDWFQGVPV GLIPVLVFAV TAFVSFSDGS SWATYGIMFP IVIPVAFTTG
ANLPLALGAV LSGGIFGDHC SPISDTTVLS SSTSGADHMV HVRTQIPYAL ICAAIAGTLF
LVLGFLVPGD FSIIPY
//
