ID M0MIS2_HALMO Unreviewed; 333 AA.
AC M0MIS2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Alcohol dehydrogenase zinc-binding domain-containing protein {ECO:0000313|EMBL:EMA44624.1};
GN ORFNames=C448_07999 {ECO:0000313|EMBL:EMA44624.1};
OS Halococcus morrhuae DSM 1307.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halococcaceae; Halococcus.
OX NCBI_TaxID=931277 {ECO:0000313|EMBL:EMA44624.1, ECO:0000313|Proteomes:UP000011568};
RN [1] {ECO:0000313|EMBL:EMA44624.1, ECO:0000313|Proteomes:UP000011568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1307 {ECO:0000313|EMBL:EMA44624.1,
RC ECO:0000313|Proteomes:UP000011568};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMA44624.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AOMC01000105; EMA44624.1; -; Genomic_DNA.
DR RefSeq; WP_004053644.1; NZ_AOMC01000105.1.
DR AlphaFoldDB; M0MIS2; -.
DR STRING; 931277.C448_07999; -.
DR PATRIC; fig|931277.6.peg.1564; -.
DR eggNOG; arCOG01621; Archaea.
DR OrthoDB; 168897at2157; -.
DR Proteomes; UP000011568; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd08255; 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43350:SF22; D-GULOSIDE 3-DEHYDROGENASE; 1.
DR PANTHER; PTHR43350; NAD-DEPENDENT ALCOHOL DEHYDROGENASE; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011568};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 150..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 158..271
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 333 AA; 36335 MW; 7D4F05B0B5762A8D CRC64;
MDRYSLRFTG PHETERRQTT FTPADDEVVV ETRVSAINAG TELLIYRGDV PTDRPADETI
DALDGDLSFP LRYGYAAVGE VIEVGIDVPS DWTGRTVFAF NPHESRFAAS PDDLVPVPED
VTPEAMAMLP AVETATSLVL DGRPRIGERV IVFGAGVIGL CTIGVLASFP LDRLVVVDPL
AERREHARRL GADETLSPAD LSTAVGIDDD GADLVYELSG QPDALDDATD VTGYDSRVIV
GSWYGTKPTT LDLGTDFHRN HVTIESSQVS TLSPATRGRW TKARRLDTAL DRLRVLDVAS
LVSHRIPFID APSAYRLLDE RTEPTLQVLL TYS
//
