ID M0QRG1_9ACTN Unreviewed; 7062 AA.
AC M0QRG1;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=Putative non-ribosomal peptide synthetase {ECO:0000313|EMBL:GAC71059.1};
GN ORFNames=GS4_49_00010 {ECO:0000313|EMBL:GAC71059.1};
OS Gordonia soli NBRC 108243.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=1223545 {ECO:0000313|EMBL:GAC71059.1, ECO:0000313|Proteomes:UP000011666};
RN [1] {ECO:0000313|EMBL:GAC71059.1, ECO:0000313|Proteomes:UP000011666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 108243 {ECO:0000313|EMBL:GAC71059.1,
RC ECO:0000313|Proteomes:UP000011666};
RA Isaki-Nakamura S., Hosoyama A., Tsuchikane K., Ando Y., Baba S., Ohji S.,
RA Hamada M., Tamura T., Yamazoe A., Yamazaki S., Fujita N.;
RT "Whole genome shotgun sequence of Gordonia soli NBRC 108243.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAC71059.1}.
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DR EMBL; BANX01000049; GAC71059.1; -; Genomic_DNA.
DR STRING; 1223545.GS4_49_00010; -.
DR eggNOG; COG1020; Bacteria.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000011666; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR CDD; cd19540; LCL_NRPS-like; 4.
DR Gene3D; 3.30.300.30; -; 6.
DR Gene3D; 3.40.50.980; -; 8.
DR Gene3D; 1.10.1200.10; ACP-like; 6.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 8.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 8.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 5.
DR Pfam; PF13193; AMP-binding_C; 4.
DR Pfam; PF00668; Condensation; 8.
DR Pfam; PF00550; PP-binding; 6.
DR SMART; SM00823; PKS_PP; 6.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 6.
DR SUPFAM; SSF47336; ACP-like; 6.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 16.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 6.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 5.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011666}.
FT DOMAIN 186..260
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1738..1812
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2811..2886
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3887..3962
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4962..5036
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 6499..6574
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 7062 AA; 745863 MW; 5B69A040B42720AF CRC64;
MWNTTTWVLD ARLRPVPVEV PGELYLGGVQ LARGYAGRPD LSAERFVADP FGGPGERLYR
TGDLVRWNHD GEIEYLGRTD FQVKLRGQRI ELGEIESVIA SVPGVVHAAA TVASAPSGAQ
HLVAYVSPAT VDLDLMRVAV AESLPEYMRP SVWMPIEHVS LNSAGKLDRR ALPEPDFGVS
ADVYVAPEGP LEEQLAGIVA ALLGIERVSV TESFFALGGD SIMSIQLSSA AKAGGLALSP
REIFEHRTIR SMARAIAGGG ARLPALPEPP GGGTGPSSLP PIVSWMIEHS ETPADFADFS
QSTVLAAPAG IDADTVREVL AVAVAAHPML TASLRLTDSG WELLTGNEFD AAGAVSTSTS
SAPVGSPEFA AAAAAAHTYA AGQLDPAAGR LVHAVLVQDP DGAGWLVVVI HHLGVDAVSW
SVLIEDLVTV WAQRNAGHDH AVRAESTSAR AWYAALAARA DVAAGASEHW LSRLPQRPTD
LGAVFDRSRD KQRTARSVVV GIDADIAEPA LTSVPRAFDG SAEDVLLAAL ARAVRSWQQS
RGIADTAPVS VLVEGHGRYE DVVAHGADPR NADLSRTIGW FTTIVPVSLE PTADIVHAVK
AAKEERLGRP EAGIGFGVLR YADTELSSRP LPSIGFNYLG NVAGGEGISG DFLPARHDLR
LPGSVSGAMV ALNSLTINAN SVPTAAGRAI SADFAFPAGL LTEEEVTDLG DRWRGELRTL
VAEVAARRDV GLSPSDVPGA AVTQADLDLI AARSPGAAVW PLSPLQRGLH FQSELASAGR
RSGAVDVYVA QAVLTLGGGV DIGRLRTAAE MLLAEHRVLR SGFVRTPSGA VVAVVPTSVE
VPWEVVEISD MDEADVERRI DRLREEQRVL PFDLREPPLV RFVVARSPRA THLIVTNHHI
VLDGWSGPLV LADLLALYAT GFTYTSQVST GTGDFADYLR RIGSADDTAG LAAWREVLAP
VDGPTLVSAS AEATVEALPR DLAVLLDAET TAGIDDLTRR HGVTAATVLQ FAWAVLLSRV
TGERVVTFGE TVSGRPADLD GVESMVGLFI NTLPAVVDVD PSALVVDVLR KVQADKVAVL
DHQHLGLPEI VTASGAPIGF DTLAVHESYP VDTDSVASAD AVEGLDIRGI DIRDSTHYPL
NFITSRSGDQ TLLKLKYLPS AFSDRQVSVF ADVLVRLLTT IAEQADRLQV ADISLVDEAD
YRAGISAPVT DTVNTDASLV ELFARSVAAN SDGVAVSDGG WSGASLRYTD LDRRSDAIAS
ALVARGVRTG DLVGVATARS VDLVSTILGV LKAGAGYLPL DTTNPTERLR FIISDATPPV
VVTDSSTAGL ELWSQLPGQT VVADVADLFD EGAGVARPLV VTHADARAYV IYTSGSTGRP
KGVEVTHRDV VTLMDTAATD FEFRSDDVWT MFHSYAFDFS VWELWGPLLS GARLVVVGRD
VARAPEEFLR LLSRERVTVL SQTPSAFYQL SDARRRDRSH PLSLRYVVFG GEALNFEQVR
RWFDEHPGDD AVLVNMYGIT ETTVHVSFRA LDPSTVRAGD ASFIGRPLAS LGIHILDDRL
RPVPEGVVGE MYVVGGQLAQ GYLRRPELTA TRFVADPFGG GGQRLYRTGD LARRVGDDIE
YLGRGDAQVQ LRGFRIEFGE VEAALLSAPG VTAAAATIVD GKGSGELLVG HVVVDDPAAL
DPQAIRQAAA AAVPAYMVPD LVVAIDAIPL TANGKLDRAA LPAPETAAVA GDYVAPASPA
QEAVAGVFAE VLGLDPAEVG ATTSFFDLGG NSLSATRVAA RIADVLAADV SVRDIFDTPT
VRELAVVAGS RGEGVTPIAA VRPRPDRIPL SFAQQRMWFI NRFDAASPAY NIPAVLRLSG
TLDVDALHDA VADVVGRHEV LRTTFPAHEG VPYQLVHPTG EAQRRLDWQI VASQTEIEDA
VMRGFDVTAD LPLRVRLWPA GRDEHVLAVV AHHIAADGES MAPLVTDVVT AYVARAAGQV
PLFVPLEVQF ADFAIWQHDV LGDADDPESI VGGQIAYWLD ELAGVPDVLE LPTDRPRPPT
ASQRGALSSF ALPAEVGERV AEVARRRGVT PFMVVHAALA VLFARLSASE DIAIATPIAG
RGQRVLDPLV GMFVNTLVLR AQVDGGATFA ELLEQVRRTD LEAFAHSDVP FETLVEQINP
VRSEAFSPLA QVMLTFNDAG RGTSITEALG GQGMSDLTLA PVEASEVPAQ LDLNVVVSAA
AAGADWHIAT TYATDLFDES TIEAFNRRFV LLLDRLTAAT QLPVGDIALL ADGDRDAIVA
AESGADVVLP EVDTVADAIA LRVAATPDAV ALIDADREVT FAEFGARVNV LGRELIATGV
GPDVAVGVCI PRSVEMLVAI HAVVAAGGQY VPIDTTAPAD RVRYMLETAN ANALLVADAS
SVAGVVEAAR AAGAAVLGVD AATPVDTETP AIRADERTGP LRPDDAVYTL FTSGSTGRPK
GVTLSHVAVL NRLWWGLDTL PIDASDAVVL KTPYTFDCSV PELFAPLIHG ARLVILRDGG
HLDPLYVAAE IARTRATMVH FVPSMLSVFL EVAGAERVRA LDSVRIVSTT GEALPPAIAA
QVRTLLPDAM LFNLYGPTEA AVEITYEHIE SVSAEDQTVP IGIPVWNSSA LVLDARLHRV
PDGVPGELYL GGVQLARGYA ARPDLTSERF VADPYGPPGS RLYRTGDLVR RTASGGIDYL
GRTDFQVKLR GQRIELGEIE SVIASAPGVV HAAATVAIAP GGGEHLVGYV AGAPGETVAI
SGVEAVLAES LPAYMRPTVW MVLDDMQLNS AGKIDRRALP DPVFTAGEYV APETDAESSV
AEVFADVLGT DRVSVTDSFF DLGGNSLSAM RLAARVGAVL GVEIGVRELF DAPTVRELAA
MAGGASAAVA PITVVDPRPD RIPLSFAQQR MWLINQVDSA SAAYNIPAVL RLSGDLDVEA
LHAAVIDVVT RHEVLRTTFP SADGVPYQKI ARASAVAARL DWDVVDSQEE IEEAVATGFD
VTRQWPIRVR VWPAAPGEHV LAVVMHHIAS DGESMAPLVT DLVTAYIAEA EDTDPEFGPL
PVQFADYALW QRENLGSTDD PDSVVGGQLA YWTDQLAGLG DVIELPTDRP RPPVATQRGA
RLDFEFSAEA GSSVRQLAQR SGTTPFMVVH AALAVLLGRL SASDDIAIGT PIANRGQAVL
DPLIGMFVNT LILRTRVDSG ETVESLLADV KATDLDAFAN ADVPFESVVE AAGAVRSDAF
APFSQVWLTF DQSALPELAG ADLASGEIAG LSVSPVATGT VPARVDLLVA VAPAAEGAWG
GSILFATDLF DESTVRGFAE HLTRIVDEMA ADATVAIGDI ALSQGLSVAD LTRAKAAAVP
APVPVVADSD AVVTGGPGTP PVLLAGIFAE AARRWGPRQA VVDAQNTVLS YAELDARSNR
LARWLIGRGI GAESLVALAI GRSAELLTAI WAVAKTGAGY VPIDPDYPAE RVATMIEDSG
AILGLAVAAS GDLPGDAFDW VRVDETTVAS EIAGHDDTAV TDADRRAAVR TDNVAYVIYT
SGSTGRPKGV AVTHTGLANF AAEEIRRSNA DEYARVLGFA SPSFDASVLE YLLATVAGGV
LIYRPSDAVG GAVLQDFMLR QAVTHTFLTP SVLATLEAPA VPALRVVYAG GEAVPQGLKD
EWAVFRRVQN LYGPTETTIG VTISAPLGVG EPITLGGPLA GVGLMVLDGR LRPVPVGVPG
ELYVAGGALS RGYLDRPGLS AERFVANPHG GPGDRMYRTG DVVRWRRNGS GEAVLEYSGR
SDDQVKLRGL RIELGEIESA LAEYDGVRSA VVIGVGGSVA TALAAYVVAD EATLEIADLK
THIAGRLPAH MVPASIQVLD ALPMTPVGKL DRNALPEPVI EAGEFVAPET DDERAVADVF
AEVLGVEEVS VTTGFFDLGG NSLSATRLAA RVAEVLDADI SVRDVFESPT VRQLATRGTG
RAAALAPITA VDPRPERIPL SFAQQRMWFI NQFDTSVATY NVPLGVRISG RIDTAALHTA
IIDVVTRHEV LRTTFPSVDG EPTQQIHAAA EIADRLDWAV VDSQADVEAA IGTGFDVTAQ
WPLRVRLWPV SETESVLAVV AHHIAADGES LAPLMTDLVT AYAARAEGAE PAFAPLDVQF
ADFALWQQDT LGAVDDPSSV LGGQLAYWSA QLAGLPDVLE LPTDHPRPRV ASQRGDFVEF
HLPAGVADRV TALAHERNAT PYMVVHAALA VLLARLAATD DVAVGTPIAG RGQRELDPLV
GMFVNTLVLR TAVDGATTFD ALLDRVRTTD LDAFANADIP FETLVERLEP TRSEAFAPLT
QVWLTLDQSV LPELGAGEES LRVGDLEITP IDPGLTPAKV DLLVGLSTAG PGEPWPGSLI
YATDLFEAGS MDVLAARLVA VLDAVTADPD VPVGAVELVS AEERAAIAGW TSGAEVDLSD
PQLREAVVEG TLADLVTAAA HRFGDAKAVT FDGRDVTFVE FAARVNTLAR RLIAAGVGPD
VAVGLCTPRS LELILALQAI VVAGGQYVPI DTAAPTDRVE YMLDTAGAHI VVVAADATPA
VVTALGERVQ VVTVDAGAPV ADVVAPVTDA ERLAPLREDH AAYTIFTSGS TGRPKGVTVS
HRSVLSQLIF DQDYYAFSGS DVFLQVLEYT FDPSVLEFFR WLYDGGRMVM MRPGEHRDPW
AVASYIADHQ VTSVMMVPSM LSSLLEATAD RDTEWISSVR HIHTGGEALT PAVADRLLQR
WPHVGLHNQY GPTEATIFAT IAEVGAGAPT VPIGVPLWHV TAHVLDARLQ IVPIGVAGEL
YLGGLQVARG YAGRPALTAE RFVADPAVPG QRLYRTGDMV RWNSAGQLEY LGRTDFQVKL
RGQRIELGEI EAVIASAPGV VHAAVTVDSA PAGGELLVGY VDGSDDLDRE ALRDYAAEHL
VEFMQPAVWM ILDHLPLSTA GKVDRRSLPS PDFSATITEI VAPTSETERV LAALVAGVLG
VDQVSVTESF FALGGDSIMS IQLTSAARAA GLSLSPREIF ELKTVRAMAS AAADQGERLP
LLRDPDGGVG RIELPQIVSW MLELSDTPAD FADFNQSRLL IAPPGADIDE ITGILTAVVD
GHPALTSRLV VVGDGWELTA GNPFDAAAAV HEVHTDTAPT SAEFATVVRD AHASAAARLD
PAAGALVQTV LIHAATGESR LLVVIHHLGV DAVSWPIVIE DLITVWSQRQ ASAPVAVRRE
ETTAVAWYAA LAEQLADRSA AELDHWLARL PQRPTDLGVQ LDRVRDREST TRNVVHRVAS
DTTEAVLTGV PEAFGATPND VLQGALARAV RTWQRRRGIS DDQPVSILSE GHGRNDEIMA
SGRAPHRADL SRTVGWFTTV APVLLDPSVD MIHAVKAAKE ERLRQPQAGT GFGLLRYRAD
SGLAGRPLPT VAFNFFGAGS ARVGDHDPTH VVPFTVAPES PGLPPTVAGG MAVAAAVSVN
VSTVHTEDGR VLVADLAYPS ALFGTDDVTE LATLWEVELA AVVADLASVG DPGPSPSDVP
GTALTQSDLD VIGVRYPGAI VWPLSPLQHG LYFQAELNSG PTSDAVDVYV TQAVLELGGD
IDAARLRTAA ADLLAHHRVL RTGYVRTESG SVVAVVVPEV ELPWQVVELD PAADAVAAVA
EVAAAERVLP FDMTAPPLIR FVLVTHSDTA SLVVTNHHIL LDGWSGPLVL ADVLALYARG
TTFTDLQAPQ AGDFGDYLRH IASADREQGL AAWRDVLAPL EEPTIVSSDV EVTATSLPRD
HVESVDAELT AAIEQVARSR GVTLTTILQF AWSVLLSRLT GNQVVAFGET VSGRPADLDG
VESMVGLFIN TLPVVVDADP AVSIATALDR LQAQKVSVLD HQHLGLPEIV ANAGLPVVFD
TLTVHESYPV NSESLSTADA ALTGGLQILG VEASDATHYP LNMATSPAAD GIEVKLKYLP
SAFGDEQVHG FAGAVRRILT AVVADQDATI GEIDLLSPAD ASELTPVSGG PAATPRLLAD
VFADVVARVP DNVAVTDGHG ASLTYSELDL RSNRIGRWLI ANGIGVDDIV ALALPRSVDL
LAAQWAVAKV GAAYLSIDPD YPAERIAHMI TDSGVTVGLT SRDTHGLGDE VRWTAIDEAR
AVGGDHPTSS APIDADELIG RPHLDAIAYV IYTSGSTGTP KGVTVSYRGA HNFAVAEVDR
LRSDETARVL GFASPSFDAS VLEWLLASTA GATLVYRPAD VLGGAPLAEF IRDQALTHVF
LTPTVLASID ETDLPALRML ASGGEAVPQA LVDRWSGRVD FVNAYGPTEA SVAVAMSSVL
TPGRPVDIGG PVPGVGLLVL DNQLRPVPVG VPGDLYADGV ALARGYRRRA GLTAERFVAH
PYGPPGARMY RTGDVVRWAR NPEGELVIDY VGRSDDQVKL RGLRIELGEI EAALASHPAV
SSAVVIGVGG SVATALAAYV VLGRPVEQTE LRDHVAHRLP THMIPASITE LDHLPLTPAG
KLDKRALPAP TAETAEFVAA DSPAEESVAA VFAEVLGVDE VSVTAGFFDL GGNSLSATRL
AARTAEVLNA DISVRDVFDA PTVRDLVALA GRRGTALAPV TAVAPRPDRV PLSFAQQRMW
FLNRFDPGST AYNIPVGLRL TGAVDPDALR AAVDDVVARH EILRTTFPAV GGAPVQLVHA
PTDAPVDWAQ VDTDEELIAA ATTGFDVTVR TPFRVRLRRV ADGEWLLVAI IHHIVGDGES
MVPLVADVVA AYGARVDGRQ PEFTPLAVQF ADYAIWQHRE LGAPDDPNSV VARQLAYWTR
QLRGVPDVID LPADRVRPAV ASNRGALHTF EIPGEVGRRI AQVAHDRGVT PFMVVHAALA
VVLSRLTATD DVTVSTPIAG RGQRELDPLV GMFVNTLILR AEVDPGMPFA DLLDQVRGTD
LEAFAHADVP FETVVQELSP TRSQAFAPLA QVMLSLVQPA PAESVHTGAG IEIAPLEPLA
VAAQVDLSFS IATGTDTWSG SLVYATDLFD EQTVATLTGR FVALLDGLTA DPTTRVGDVP
LVAPAELERI VNWSSGTPGP VVDTTLPTLL NRNHGLSADD DR
//
