ID M0QW04_BOVIN Unreviewed; 323 AA.
AC M0QW04;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=NADP-dependent oxidoreductase domain-containing protein {ECO:0000259|Pfam:PF00248};
GN Name=LOC538060 {ECO:0000313|Ensembl:ENSBTAP00000014388.6};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000014388.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000014388.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000014388.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000014388.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000014388.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family.
CC {ECO:0000256|ARBA:ARBA00007905}.
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DR RefSeq; XP_002692229.1; XM_002692183.5.
DR RefSeq; XP_015321488.1; XM_015466002.1.
DR AlphaFoldDB; M0QW04; -.
DR SMR; M0QW04; -.
DR STRING; 9913.ENSBTAP00000014388; -.
DR PaxDb; 9913-ENSBTAP00000023326; -.
DR Ensembl; ENSBTAT00000014388.6; ENSBTAP00000014388.6; ENSBTAG00000051758.1.
DR VEuPathDB; HostDB:ENSBTAG00000051758; -.
DR eggNOG; KOG1577; Eukaryota.
DR GeneTree; ENSGT00940000153677; -.
DR InParanoid; M0QW04; -.
DR OMA; YEFSECK; -.
DR Reactome; R-BTA-193368; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
DR Reactome; R-BTA-193775; Synthesis of bile acids and bile salts via 24-hydroxycholesterol.
DR Reactome; R-BTA-193807; Synthesis of bile acids and bile salts via 27-hydroxycholesterol.
DR Reactome; R-BTA-975634; Retinoid metabolism and transport.
DR Reactome; R-BTA-9757110; Prednisone ADME.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000051758; Expressed in ruminant reticulum and 25 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0047023; F:androsterone dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0032052; F:bile acid binding; IBA:GO_Central.
DR GO; GO:0047086; F:ketosteroid monooxygenase activity; IBA:GO_Central.
DR GO; GO:0044597; P:daunorubicin metabolic process; IBA:GO_Central.
DR GO; GO:0044598; P:doxorubicin metabolic process; IBA:GO_Central.
DR GO; GO:0042448; P:progesterone metabolic process; IBA:GO_Central.
DR GO; GO:0006693; P:prostaglandin metabolic process; IBA:GO_Central.
DR CDD; cd19108; AKR_AKR1C1-35; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR044482; AKR1C.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR11732:SF533; ALDO-KETO REDUCTASE FAMILY 1 MEMBER C4; 1.
DR PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 19..300
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 55
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 117
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 84
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 323 AA; 37156 MW; A2DB32EA583AFECF CRC64;
MDPKGQRVKL NDGHFIPVLG FGTAVPPEVP KREALEVTRF AIEVGFRHID CAYVYKNEEH
VGQAIRSKIA DGTVKREDIF YTSKLWCTFH QPELVRPALE KSLKNLQLDY VDLYIIHFPL
AMKPGEELFP KDENGKLIFD LVDLCHTWEA LEKCKDAGLT KSIGVSNFNR KQLEKILNKP
GLKYKPVCNQ VECHPYLNQS KLLDFCKSHD IVLVAYGALG SQRIKEWVNP NHPVLLEDPV
LCAIAKKHKQ TPALVALHYQ VQRGVVVLAK SYNKKRIKEN IQVFDFELSP DDMKAIDGLN
RNLRYYEFLI GLSHPEYPYH EEY
//
