ID M0QYQ6_HUMAN Unreviewed; 282 AA.
AC M0QYQ6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=F-box protein 27 {ECO:0000313|Ensembl:ENSP00000470015.1};
GN Name=FBXO27 {ECO:0000313|Ensembl:ENSP00000470015.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000470015.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000470015.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000470015.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC010605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC011455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M0QYQ6; -.
DR SMR; M0QYQ6; -.
DR MassIVE; M0QYQ6; -.
DR PeptideAtlas; M0QYQ6; -.
DR Antibodypedia; 30249; 150 antibodies from 22 providers.
DR Ensembl; ENST00000600828.5; ENSP00000470015.1; ENSG00000161243.10.
DR UCSC; uc060yil.1; human.
DR HGNC; HGNC:18753; FBXO27.
DR VEuPathDB; HostDB:ENSG00000161243; -.
DR GeneTree; ENSGT00940000161841; -.
DR HOGENOM; CLU_068548_2_0_1; -.
DR ChiTaRS; FBXO27; human.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000161243; Expressed in secondary oocyte and 102 other cell types or tissues.
DR ExpressionAtlas; M0QYQ6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR007397; F-box-assoc_dom.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR039752; F-box_only.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR12125:SF9; F-BOX ONLY PROTEIN 27; 1.
DR PANTHER; PTHR12125; F-BOX ONLY PROTEIN 6-LIKE PROTEIN; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF04300; FBA; 1.
DR SMART; SM01198; FBA; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS51114; FBA; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:M0QYQ6,
KW ECO:0007829|PeptideAtlas:M0QYQ6};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 23..70
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT DOMAIN 104..279
FT /note="FBA"
FT /evidence="ECO:0000259|PROSITE:PS51114"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 282 AA; 31494 MW; 0B36A4F411B5FFC6 CRC64;
MGASVSRGRA ARVPAPEPEP EEALDLSQLP PELLLVVLSH VPPRTLLGRC RQVCRGWRAL
VDGQALWLLI LARDHGATGR ALLHLARSCQ SPARNARPCP LGRFCARRPI GRNLIRNPCG
QGLRKWMVQH GGDGWVVEEN RTTVPGAPSQ TCFVTSFSWC CKKQVLDLEE EGLWPELLDS
GRIEICVSDW WGARHDSGCM YRLLVQLLDA NQTVLDKFSA VPDPIPQWNN NACLHVTHVF
SNIKMGVRFV SFEHRGQDTQ FWAGHYGARV TNSSVIVRVR LS
//
