ID M0QZ92_HUMAN Unreviewed; 97 AA.
AC M0QZ92;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=SEC7 domain-containing protein {ECO:0000259|PROSITE:PS50190};
DE Flags: Fragment;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000470383.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000470383.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000470383.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC008403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M0QZ92; -.
DR SMR; M0QZ92; -.
DR STRING; 9606.ENSP00000470383; -.
DR BioMuta; ENSG00000268465; -.
DR MassIVE; M0QZ92; -.
DR PeptideAtlas; M0QZ92; -.
DR Ensembl; ENST00000595676.1; ENSP00000470383.1; ENSG00000268465.1.
DR UCSC; uc061atn.1; human.
DR GeneCards; ENSG00000268465; -.
DR VEuPathDB; HostDB:ENSG00000268465; -.
DR HOGENOM; CLU_032820_2_1_1; -.
DR PhylomeDB; M0QZ92; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; M0QZ92; Protein.
DR Bgee; ENSG00000268465; Expressed in primordial germ cell in gonad and 87 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR Gene3D; 1.10.220.20; -; 1.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF343; CYTOHESIN-2; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF01369; Sec7; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 38..97
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT COILED 3..37
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 97
FT /evidence="ECO:0000313|Ensembl:ENSP00000470383.1"
SQ SEQUENCE 97 AA; 11308 MW; 1386D0A7067146F6 CRC64;
MELENIRRRK QELLVEIQRL REELSEAMSE VEGLEANEGS KTLQRNRKMA MGRKKFNMDP
KKGIQFLVEN ELLQNTPEEI ARFLYKGEGL NKTAIGD
//
