ID M0R1G2_HUMAN Unreviewed; 437 AA.
AC M0R1G2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Adhesion G protein-coupled receptor E3 {ECO:0000313|Ensembl:ENSP00000471853.1};
GN Name=ADGRE3 {ECO:0000313|Ensembl:ENSP00000471853.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000471853.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000471853.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000471853.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AC022149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC135052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016882872.1; XM_017027383.1.
DR AlphaFoldDB; M0R1G2; -.
DR SMR; M0R1G2; -.
DR MassIVE; M0R1G2; -.
DR PeptideAtlas; M0R1G2; -.
DR Antibodypedia; 2861; 383 antibodies from 31 providers.
DR DNASU; 84658; -.
DR Ensembl; ENST00000599900.5; ENSP00000471853.1; ENSG00000131355.15.
DR UCSC; uc060uqh.1; human.
DR HGNC; HGNC:23647; ADGRE3.
DR VEuPathDB; HostDB:ENSG00000131355; -.
DR GeneTree; ENSGT00940000163037; -.
DR HOGENOM; CLU_002753_3_7_1; -.
DR OrthoDB; 1114672at2759; -.
DR BioGRID-ORCS; 84658; 15 hits in 1146 CRISPR screens.
DR ChiTaRS; ADGRE3; human.
DR GenomeRNAi; 84658; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000131355; Expressed in blood and 80 other cell types or tissues.
DR ExpressionAtlas; M0R1G2; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR001740; GPCR_2_EMR1-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011:SF455; ADHESION G PROTEIN-COUPLED RECEPTOR E3; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR01128; EMR1HORMONER.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 1: Evidence at protein level;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|MaxQB:M0R1G2,
KW ECO:0007829|PeptideAtlas:M0R1G2}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023040};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 143..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 141..387
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 406..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 437 AA; 48811 MW; 88300CB9ABC9946F CRC64;
MNSMDIRCSD IIQGDTQGPS AIAFISYSSL GNIINATFFE EMDKKDQVYL NSQVVSAAIG
PKRNVSLSKS VTLTFQHVKM TPSTKKVFCV YWKSTGQGSQ WSRDGCFLIH VNKSHTMCNC
SHLSSFAVLM ALTSQEEDPV LTVITYVGLS VSLLCLLLAA LTFLLCKAIR NTSTSLHLQL
SLCLFLAHLL FLVGIDRTEP KVLCSIIAGA LHYLYLAAFT WMLLEGVHLF LTARNLTVVN
YSSINRLMKW IMFPVGYGVP AVTVAISAAS WPHLYGTADR CWLHLDQGFM WSFLGPVCAI
FSANLVLFIL VFWILKRKLS SLNSEVSTIQ NTRMLAFKAT AQLFILGCTW CLGLLQVGPA
AQVMAYLFTI INSLQGFFIF LVYCLLSQQV QKQYQKWFRE IVKSKSESET YTLSSKMGPD
SKPSEGDVFP GQVKRKY
//
