ID M0R2T8_HUMAN Unreviewed; 85 AA.
AC M0R2T8;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Homer scaffold protein 3 {ECO:0000313|Ensembl:ENSP00000472800.1};
DE Flags: Fragment;
GN Name=HOMER3 {ECO:0000313|Ensembl:ENSP00000472800.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000472800.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000472800.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000472800.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AC002985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M0R2T8; -.
DR SMR; M0R2T8; -.
DR MassIVE; M0R2T8; -.
DR MaxQB; M0R2T8; -.
DR PeptideAtlas; M0R2T8; -.
DR Antibodypedia; 28304; 262 antibodies from 27 providers.
DR Ensembl; ENST00000599097.1; ENSP00000472800.1; ENSG00000051128.19.
DR UCSC; uc060vvr.1; human.
DR HGNC; HGNC:17514; HOMER3.
DR VEuPathDB; HostDB:ENSG00000051128; -.
DR GeneTree; ENSGT00940000158081; -.
DR HOGENOM; CLU_144357_1_0_1; -.
DR OMA; QRCGRWE; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000051128; Expressed in cerebellar vermis and 197 other cell types or tissues.
DR ExpressionAtlas; M0R2T8; baseline and differential.
DR GO; GO:0035256; F:G protein-coupled glutamate receptor binding; IEA:InterPro.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045027; Homer.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR10918; HOMER; 1.
DR PANTHER; PTHR10918:SF4; HOMER PROTEIN HOMOLOG 3; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50229; WH1; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:M0R2T8,
KW ECO:0007829|MaxQB:M0R2T8};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 1..85
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT NON_TER 85
FT /evidence="ECO:0000313|Ensembl:ENSP00000472800.1"
SQ SEQUENCE 85 AA; 9537 MW; 7FECC9DCBDD85DCE CRC64;
MSTAREQPIF STRAHVFQID PATKRNWIPA GKHALTVSYF YDATRNVYRI ISIGGAKAII
NSTVTPNMTF TKTSQKFGQW ADSRA
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