ID M0R7R7_RAT Unreviewed; 438 AA.
AC M0R7R7;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Nuclear envelope integral membrane protein 1 {ECO:0000313|Ensembl:ENSRNOP00000065499.3};
GN Name=Nemp1 {ECO:0000313|Ensembl:ENSRNOP00000065499.3,
GN ECO:0000313|RGD:1587179};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000065499.3, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000065499.3, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000065499.3,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000065499.3}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000065499.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000256|ARBA:ARBA00004575}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004575}; Nucleoplasmic side
CC {ECO:0000256|ARBA:ARBA00004575}.
CC -!- SIMILARITY: Belongs to the NEMP family.
CC {ECO:0000256|ARBA:ARBA00005748}.
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DR RefSeq; NP_001258178.1; NM_001271249.1.
DR AlphaFoldDB; M0R7R7; -.
DR STRING; 10116.ENSRNOP00000065499; -.
DR PaxDb; 10116-ENSRNOP00000065499; -.
DR Ensembl; ENSRNOT00000072906.3; ENSRNOP00000065499.3; ENSRNOG00000046492.3.
DR GeneID; 679504; -.
DR KEGG; rno:679504; -.
DR AGR; RGD:1587179; -.
DR CTD; 23306; -.
DR RGD; 1587179; Nemp1.
DR VEuPathDB; HostDB:ENSRNOG00000046492; -.
DR eggNOG; KOG3817; Eukaryota.
DR GeneTree; ENSGT00390000002174; -.
DR HOGENOM; CLU_025225_0_0_1; -.
DR OMA; MAGCMKM; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000046492; Expressed in testis and 19 other cell types or tissues.
DR GO; GO:0005635; C:nuclear envelope; ISO:RGD.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043131; P:erythrocyte enucleation; IEA:Ensembl.
DR GO; GO:0071763; P:nuclear membrane organization; ISO:RGD.
DR InterPro; IPR019358; NEMP_fam.
DR PANTHER; PTHR13598:SF2; NUCLEAR ENVELOPE INTEGRAL MEMBRANE PROTEIN 1; 1.
DR PANTHER; PTHR13598; UNCHARACTERIZED; 1.
DR Pfam; PF10225; NEMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ SEQUENCE 438 AA; 49599 MW; 8CE68C0D9C560BF1 CRC64;
MAGGIKVAVW SAVGPGPGCC GAGGGGAAWL LLVVAGCVVG CSAGIDVNVV MLQESQVDMN
SSQQFCYKNV LIPKWHDIWT RIQVRVNSSK LVRVTQVDSE ERLKELEQFS VWNSLSSFLK
EKLNDTYVNV GLYSTKTCLK VEIIEKDTKY SVIVTRRFDP KLFLVFLLGL TLFFCGDLLS
RSQIFYYSTG MSVGIVASLL IVIFMISKLM PKRSPIYVIL VGGWSFSLYL IQLVFKNLQE
IWRCYWHYLL SYILTVGFMS FAVCYKYGPL ENERSINLLT WTLQLLGLGF MYSGIQIPHV
AFALIVIALC TKNLEYPIYW LYSTYRRMCK ASEKPVPPRL LTEEEYRIQG EVETQKALQE
LREFCNSPEC SAWKTISRIQ SPKRFADFVE GSFHLTPNEV SVHEQEYGLG SILAQDEELS
SEEEGSEDLP LTQNSFLT
//
