ID M0RCN2_RAT Unreviewed; 311 AA.
AC M0RCN2; A0A0U5J7G4;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=TNF superfamily member 14 {ECO:0000313|Ensembl:ENSRNOP00000067356.2};
DE SubName: Full=Tumor necrosis factor ligand 1d {ECO:0000313|EMBL:CTQ86172.1};
GN Name=Tnfsf14 {ECO:0000313|Ensembl:ENSRNOP00000067356.2,
GN ECO:0000313|RGD:1588572};
GN Synonyms=Tnlg1d {ECO:0000313|EMBL:CTQ86172.1};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000067356.2, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000067356.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000067356.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|EMBL:CTQ86172.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26646413; DOI=10.1007/s00251-015-0887-5;
RA Premzl M.;
RT "Comparative genomic analysis of eutherian tumor necrosis factor ligand
RT genes.";
RL Immunogenetics 68:125-132(2016).
RN [3] {ECO:0000313|EMBL:CTQ86172.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.genrep.2019.100414;
RA Premzl M.;
RT "Eutherian third-party data gene collections.";
RL Gene Rep 16:100414-100414(2019).
RN [4] {ECO:0000313|Ensembl:ENSRNOP00000067356.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000067356.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; LN874407; CTQ86172.1; -; mRNA.
DR STRING; 10116.ENSRNOP00000067356; -.
DR PaxDb; 10116-ENSRNOP00000067356; -.
DR Ensembl; ENSRNOT00000074247.2; ENSRNOP00000067356.2; ENSRNOG00000047730.2.
DR AGR; RGD:1588572; -.
DR RGD; 1588572; Tnfsf14.
DR VEuPathDB; HostDB:ENSRNOG00000047730; -.
DR eggNOG; ENOG502RZ4W; Eukaryota.
DR GeneTree; ENSGT01060000248544; -.
DR HOGENOM; CLU_070352_5_1_1; -.
DR OMA; HYYLYSK; -.
DR OrthoDB; 5342809at2759; -.
DR Reactome; R-RNO-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-RNO-5676594; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000047730; Expressed in thymus and 8 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ISO:RGD.
DR GO; GO:0005102; F:signaling receptor binding; ISO:RGD.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; ISO:RGD.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0045663; P:positive regulation of myoblast differentiation; ISO:RGD.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; ISO:RGD.
DR GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; ISO:RGD.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; ISO:RGD.
DR GO; GO:0010818; P:T cell chemotaxis; ISO:RGD.
DR GO; GO:0031295; P:T cell costimulation; ISO:RGD.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11471:SF34; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14; 1.
DR Pfam; PF00229; TNF; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 165..311
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 311 AA; 33766 MW; 2AC03BF48BA92777 CRC64;
MGAGPSGGTG RRGGCMREGA VPNFSFKMSP RGHRNLLQFA KPKHWAIVVS SGEKELRLAN
PDPGLLSLSC SGMESVVQPS VFVVDGQTDI PFRRLGQNHR RRHCGTVQVS LALLLLLGAG
LATEGWFLLR LHQRLGDIVA HLPDGGKGSW EKLIQDQRSH QPNPAAHLTG ANASLIGIGG
PLLWETQLGL AFLRGLTYHD GALVTTEAGY YYVYSKVQLS GVGCPQGLAN GLPITHGLYK
RTSRYPKELE LLVSRRSPCG RANSSRVWWD SSFLGGVVHL EAGEEVVVRV PGNRLVRPRD
GTRSYFGAFM I
//
