ID M0RDC8_RAT Unreviewed; 446 AA.
AC M0RDC8;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Mitochondrial translation release factor 1 {ECO:0000313|Ensembl:ENSRNOP00000067626.1};
GN Name=Mtrf1 {ECO:0000313|Ensembl:ENSRNOP00000067626.1,
GN ECO:0000313|RGD:1584329};
GN Synonyms=LOC686234 {ECO:0000313|RGD:1584329};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000067626.1, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000067626.1, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000067626.1,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000067626.1}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000067626.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000256|ARBA:ARBA00010835}.
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DR RefSeq; XP_001073018.1; XM_001073018.6.
DR RefSeq; XP_003751566.1; XM_003751518.4.
DR RefSeq; XP_006222102.1; XM_006222040.3.
DR RefSeq; XP_006222103.1; XM_006222041.3.
DR RefSeq; XP_006252429.1; XM_006252367.3.
DR RefSeq; XP_006252430.1; XM_006252368.3.
DR RefSeq; XP_008768353.1; XM_008770131.2.
DR RefSeq; XP_008769149.1; XM_008770927.2.
DR AlphaFoldDB; M0RDC8; -.
DR SMR; M0RDC8; -.
DR STRING; 10116.ENSRNOP00000067626; -.
DR PaxDb; 10116-ENSRNOP00000067626; -.
DR Ensembl; ENSRNOT00000072969.4; ENSRNOP00000067626.1; ENSRNOG00000047106.4.
DR GeneID; 686234; -.
DR KEGG; rno:686234; -.
DR AGR; RGD:1584329; -.
DR CTD; 9617; -.
DR RGD; 1584329; Mtrf1.
DR eggNOG; KOG2726; Eukaryota.
DR GeneTree; ENSGT00940000156877; -.
DR HOGENOM; CLU_036856_0_3_1; -.
DR OMA; ECQQSRS; -.
DR OrthoDB; 131884at2759; -.
DR Proteomes; UP000002494; Chromosome 15.
DR Bgee; ENSRNOG00000047106; Expressed in quadriceps femoris and 19 other cell types or tissues.
DR ExpressionAtlas; M0RDC8; baseline and differential.
DR GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR GO; GO:0016149; F:translation release factor activity, codon specific; ISO:RGD.
DR GO; GO:0070126; P:mitochondrial translational termination; ISO:RGD.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.30.70.1660; -; 2.
DR Gene3D; 6.10.140.1950; -; 1.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR PANTHER; PTHR43804; LD18447P; 1.
DR PANTHER; PTHR43804:SF1; PEPTIDE CHAIN RELEASE FACTOR 1, MITOCHONDRIAL; 1.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SMART; SM00937; PCRF; 1.
DR SUPFAM; SSF75620; Release factor; 1.
DR PROSITE; PS00745; RF_PROK_I; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
SQ SEQUENCE 446 AA; 52320 MW; FA920E716817C574 CRC64;
MSFHLCVWLF RNLSSLSACS QRHVFLYGQQ FRQINLDPRL WNFRQNKTHV LYRLLNKSWS
RGYCQGTRKL WKHKALQKYM EGLNDEYQSL DQCLQDISED EGDRRASHRR HAELAPLVAV
YQEIQEAEQA IEELESMCKS LNKQDEKQLQ ELVSEERQII DQKIHRLYSE LLEHLVPKEK
CDRSNVILEV TSGRTTGGDI CQQFTREIFD MYQNYSYYKH WRFELLNYTP ADYGGLHHAA
ARISGDSVYK HLKYEGGIHR VQRIPEVGLS SRMQRIHTGT MSVIVLPQPD EVDVKVDPRD
LRVDTFRARG AGGQHVNTTD SAVRLVHIPT GLVVECQQER SQLKNKEIAL RVLRARLYQQ
IIEKDKCQQQ NARKLQVGTR AQSERIRTYN FTQDRVTDHR IAYEVRDIKE FLRGEKCLDQ
LIERLLQSAD EEAIAEFLDE SLQSVK
//
