ID M0VIW3_HORVV Unreviewed; 334 AA.
AC M0VIW3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=rRNA N-glycosylase {ECO:0000256|RuleBase:RU004915};
DE EC=3.2.2.22 {ECO:0000256|RuleBase:RU004915};
OS Hordeum vulgare subsp. vulgare (Domesticated barley).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Hordeinae; Hordeum.
OX NCBI_TaxID=112509 {ECO:0000313|EnsemblPlants:HORVU.MOREX.r3.4HG0349720.1.CDS1, ECO:0000313|Proteomes:UP000011116};
RN [1] {ECO:0000313|Proteomes:UP000011116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Morex {ECO:0000313|Proteomes:UP000011116};
RX PubMed=23075845; DOI=10.1038/nature11543;
RG The International Barley Genome Sequencing Consortium;
RA Mayer K.F., Waugh R., Brown J.W., Schulman A., Langridge P., Platzer M.,
RA Fincher G.B., Muehlbauer G.J., Sato K., Close T.J., Wise R.P., Stein N.;
RT "A physical, genetic and functional sequence assembly of the barley
RT genome.";
RL Nature 491:711-716(2012).
RN [2] {ECO:0000313|EnsemblPlants:HORVU.MOREX.r3.4HG0349720.1.CDS1}
RP IDENTIFICATION.
RC STRAIN=subsp. vulgare
RC {ECO:0000313|EnsemblPlants:HORVU.MOREX.r3.4HG0349720.1.CDS1};
RG EnsemblPlants;
RL Submitted (JAN-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endohydrolysis of the N-glycosidic bond at one specific
CC adenosine on the 28S rRNA.; EC=3.2.2.22;
CC Evidence={ECO:0000256|RuleBase:RU004915};
CC -!- SIMILARITY: Belongs to the ribosome-inactivating protein family.
CC {ECO:0000256|RuleBase:RU004915}.
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DR AlphaFoldDB; M0VIW3; -.
DR EnsemblPlants; HORVU.MOREX.r3.4HG0349720.1; HORVU.MOREX.r3.4HG0349720.1.CDS1; HORVU.MOREX.r3.4HG0349720.
DR Gramene; HORVU.MOREX.r3.4HG0349720.1; HORVU.MOREX.r3.4HG0349720.1.CDS1; HORVU.MOREX.r3.4HG0349720.
DR Proteomes; UP000011116; Chromosome 4H.
DR GO; GO:0030598; F:rRNA N-glycosylase activity; IEA:UniProtKB-EC.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0017148; P:negative regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.420.10; Ricin (A subunit), domain 1; 1.
DR InterPro; IPR036041; Ribosome-inact_prot_sf.
DR InterPro; IPR001574; Ribosome_inactivat_prot.
DR InterPro; IPR016138; Ribosome_inactivat_prot_sub1.
DR PANTHER; PTHR33453; -; 1.
DR PANTHER; PTHR33453:SF40; RRNA N-GLYCOSYLASE; 1.
DR Pfam; PF00161; RIP; 1.
DR SUPFAM; SSF56371; Ribosome inactivating proteins (RIP); 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU004915};
KW Plant defense {ECO:0000256|RuleBase:RU004915};
KW Protein synthesis inhibitor {ECO:0000256|RuleBase:RU004915};
KW Reference proteome {ECO:0000313|Proteomes:UP000011116};
KW Toxin {ECO:0000256|RuleBase:RU004915}.
SQ SEQUENCE 334 AA; 37523 MW; 25B55B2CB6572F1B CRC64;
MKNLREQLTF ARHERLDRPL LAKFRPDNPA RWMHVKLVSD NHEATLAIRD DTVYLIGFQA
RNGTWYEFSS SKPSLHLPPQ KKESSLHLIE GSTFLDCGVT YGDLLGGAMN LVNMRLGHLQ
VNLGKLFAIE AVRLLSEYSG GGLTDNHKKA LAGLILIICE SARMISHFDT VINGWPRAGG
KSISRQQVHY VWNWGNMSRF LTGRSRSLQD EERLRQSCGI TTEELALGIV HLLLNSPQPP
YPTAAGQAAT AGRLWRRRAF GPWESPADTT VYCEPRRTRP PAAAKVVICE PWRTRPPPAA
EAEAIVWDWA PWPTPGGGVF RACQLPCSRH HRRL
//
