ID M0YES3_HORVV Unreviewed; 245 AA.
AC M0YES3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=cysteine dioxygenase {ECO:0000256|ARBA:ARBA00013133};
DE EC=1.13.11.20 {ECO:0000256|ARBA:ARBA00013133};
OS Hordeum vulgare subsp. vulgare (Domesticated barley).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Hordeinae; Hordeum.
OX NCBI_TaxID=112509 {ECO:0000313|EnsemblPlants:HORVU.MOREX.r3.6HG0605360.1, ECO:0000313|Proteomes:UP000011116};
RN [1] {ECO:0000313|Proteomes:UP000011116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Morex {ECO:0000313|Proteomes:UP000011116};
RX PubMed=23075845; DOI=10.1038/nature11543;
RG The International Barley Genome Sequencing Consortium;
RA Mayer K.F., Waugh R., Brown J.W., Schulman A., Langridge P., Platzer M.,
RA Fincher G.B., Muehlbauer G.J., Sato K., Close T.J., Wise R.P., Stein N.;
RT "A physical, genetic and functional sequence assembly of the barley
RT genome.";
RL Nature 491:711-716(2012).
RN [2] {ECO:0000313|EnsemblPlants:HORVU.MOREX.r3.6HG0605360.1}
RP IDENTIFICATION.
RC STRAIN=subsp. vulgare
RC {ECO:0000313|EnsemblPlants:HORVU.MOREX.r3.6HG0605360.1};
RG EnsemblPlants;
RL Submitted (JAN-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-cysteine + O2 = 3-sulfino-L-alanine + H(+);
CC Xref=Rhea:RHEA:20441, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:35235, ChEBI:CHEBI:61085; EC=1.13.11.20;
CC Evidence={ECO:0000256|ARBA:ARBA00024284};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20442;
CC Evidence={ECO:0000256|ARBA:ARBA00024284};
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SIMILARITY: Belongs to the cysteine dioxygenase family.
CC {ECO:0000256|ARBA:ARBA00006622}.
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DR AlphaFoldDB; M0YES3; -.
DR PaxDb; 4513-MLOC_68556-1; -.
DR EnsemblPlants; HORVU.MOREX.r3.6HG0605360.1; HORVU.MOREX.r3.6HG0605360.1; HORVU.MOREX.r3.6HG0605360.
DR Gramene; HORVU.MOREX.r2.6HG0501880.1; HORVU.MOREX.r2.6HG0501880.1; HORVU.MOREX.r2.6HG0501880.
DR Gramene; HORVU.MOREX.r3.6HG0605360.1; HORVU.MOREX.r3.6HG0605360.1; HORVU.MOREX.r3.6HG0605360.
DR Proteomes; UP000011116; Chromosome 6H.
DR ExpressionAtlas; M0YES3; baseline and differential.
DR GO; GO:0017172; F:cysteine dioxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070483; P:detection of hypoxia; IEA:UniProt.
DR CDD; cd20289; cupin_ADO; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR012864; PCO/ADO.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR PANTHER; PTHR22966:SF76; CYSTEINE DIOXYGENASE; 1.
DR PANTHER; PTHR22966; UNCHARACTERIZED; 1.
DR Pfam; PF07847; PCO_ADO; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011116}.
SQ SEQUENCE 245 AA; 27508 MW; FDE43B3BF5D4CBBF CRC64;
MPKIKNLSDA CKVSFSPDGP ISEETLERVR ALLDEIRPLD LGLDNEAQIA RNWNSSTRQQ
NGRRGRGGPN QYAPSIKYLH IHECESFSMG IFCMPPSSVI PLHNHPGMTV LSKLLYGKLH
AESYDWIDVA DPTDPLKPRP ARCVRDREMT APETTILYPD RGGNIHTFRA ITPCALFDVL
SPPYSAENGR DCSYFRKSPV KEPSVVLPSE IDSSEVVWLE ELEDHQPPEG FVVARGLYKG
PVIRR
//
