ID   M0ZLK9_SOLTU            Unreviewed;       607 AA.
AC   M0ZLK9;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=CSC1-like protein HYP1 {ECO:0008006|Google:ProtNLM};
GN   Name=102601755 {ECO:0000313|EnsemblPlants:PGSC0003DMT400003400};
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400003400, ECO:0000313|Proteomes:UP000011115};
RN   [1] {ECO:0000313|Proteomes:UP000011115}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX   PubMed=21743474; DOI=10.1038/nature10158;
RG   The Potato Genome Sequencing Consortium;
RT   "Genome sequence and analysis of the tuber crop potato.";
RL   Nature 475:189-195(2011).
RN   [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400003400}
RP   IDENTIFICATION.
RC   STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400003400};
RG   EnsemblPlants;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC       {ECO:0000256|ARBA:ARBA00007779}.
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DR   AlphaFoldDB; M0ZLK9; -.
DR   EnsemblPlants; PGSC0003DMT400003400; PGSC0003DMT400003400; PGSC0003DMG400001342.
DR   Gramene; PGSC0003DMT400003400; PGSC0003DMT400003400; PGSC0003DMG400001342.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   ExpressionAtlas; M0ZLK9; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR   InterPro; IPR045122; Csc1-like.
DR   InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR   InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR   InterPro; IPR032880; Csc1/OSCA1-like_N.
DR   PANTHER; PTHR13018:SF109; CSC1-LIKE PROTEIN HYP1; 1.
DR   PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR   Pfam; PF14703; PHM7_cyt; 1.
DR   Pfam; PF02714; RSN1_7TM; 1.
DR   Pfam; PF13967; RSN1_TM; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        6..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        97..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        353..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        388..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        449..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        481..500
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        548..575
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          5..167
FT                   /note="CSC1/OSCA1-like N-terminal transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF13967"
FT   DOMAIN          188..343
FT                   /note="CSC1/OSCA1-like cytosolic"
FT                   /evidence="ECO:0000259|Pfam:PF14703"
FT   DOMAIN          356..584
FT                   /note="CSC1/OSCA1-like 7TM region"
FT                   /evidence="ECO:0000259|Pfam:PF02714"
FT   COILED          232..295
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   607 AA;  69178 MW;  20592C928D4C9D0B CRC64;
     MILSALLTSV GINLGLCFLF FTLYSILRKQ PGNAEVYAPR LVAQGKSQQS SNFNLERLLP
     SAGWVTRAWR PSEAELLSTS GLDAVVFMRI FIFSARVFTF AVIVGIFILL PINYMGKQLS
     LDLFDLPNKS LESFTISNVD DGSNRLWIHF SAVYVLTAVV CYLLYFEYDY ISSKRISYFY
     SSKPHPHQFT ILVRSIPASS GRSYSETVES FFSEYYPATY LSHWVVRRAS KLQDLIKNSK
     RLYRRLVNLK SANPDRERFG RAGFMGLFGQ RVDLLDHYEK KLEVIEDNVR AEQSSCLGKE
     VGAAFVSFRT RFAAASAIHM QQGVNPTQWV TETAPDPEDV YWPFFSASFL KRWISNLVVV
     VACVLLTVLF LIPVLIVQGL THLEQLEIWF PFLKGLLRIA FVSQVITGYL PSLVLQLFLY
     VVPSIMIMFS SIQGYIAMSQ IEKSACIKVL WFTIWNIFFA NVLSGSALYR VEIFLEPKNI
     PAILAVAVPG QATFFIAYVV TSGWTSTSSE LFQLSTLVSN FIKRNICRKY DDEFEVPSVP
     YHSEIPRILL FGLLGITYFF LAPLILPFLL VYYCLGYLIY RNQVGCTFFF CFLGIHKNDE
     FYFVGPC
//