ID M0ZLV4_SOLTU Unreviewed; 1151 AA.
AC M0ZLV4;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN Name=102605224 {ECO:0000313|EnsemblPlants:PGSC0003DMT400003533};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400003533, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400003533}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400003533};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR RefSeq; XP_006338514.1; XM_006338452.2.
DR AlphaFoldDB; M0ZLV4; -.
DR STRING; 4113.M0ZLV4; -.
DR PaxDb; 4113-PGSC0003DMT400003533; -.
DR EnsemblPlants; PGSC0003DMT400003533; PGSC0003DMT400003533; PGSC0003DMG400001394.
DR GeneID; 102605224; -.
DR Gramene; PGSC0003DMT400003533; PGSC0003DMT400003533; PGSC0003DMG400001394.
DR KEGG; sot:102605224; -.
DR eggNOG; KOG1958; Eukaryota.
DR HOGENOM; CLU_004690_1_0_1; -.
DR InParanoid; M0ZLV4; -.
DR OMA; GHQWLKY; -.
DR OrthoDB; 5474711at2759; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0004559; F:alpha-mannosidase activity; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR GO; GO:0006491; P:N-glycan processing; IBA:GO_Central.
DR CDD; cd10809; GH38N_AMII_GMII_SfManIII_like; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF3; LYSOSOMAL ALPHA-MANNOSIDASE; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT TRANSMEM 39..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 487..572
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1151 AA; 132217 MW; 5425613748E65112 CRC64;
MAFSSRRGGT GWAHSLLPTS KSSSRQPRKS RRRTALRDFF LSNFFTIGLS FSLFIFILIV
YSYGVPKPLL SSHFRAARTR FHRLRKPTYR KSPGSDAVSG AVVDITTKDL YDKIQFRDED
GGAWKQGWNV NYKGNEWDSE KLKIFVVPHS HNDPGWKLTV EEYYDRQSKH ILDTLVETLP
KDSRRKFIWE EMSYLERWWR DATNEKKETF TNLVRNGQLE IVGGGWVMND EANSHYFAII
EQITEGNMWL NETIGVIPKN SWAIDPFGYS PTMAYLLRRM GFENMLIQRT HYELKKELAL
NQNLEYVWRQ SWDAEERTDI FVHMMPFYSY DVPHTCGPEP AICCQFDFAR MYGFPYERCP
WGEHPEETTQ ENVKERALKL LDQYRKKSTL YRTNTLLVPL GDDFRYVSVD EAEAQFRNYQ
MLFDYINSNP GLNAEANFGT LDDYFRTLRD EADRVNYSRP HEIGSGEIGG FPSLSGDFFT
YADRQQDYWS GYYVSRPFFK AVDRVLEHNL RSAEMLMAFL LGYCQRIQCE KLPTGFSYKL
TAARRNLALF QHHDGVTGTA KDHVVQDYGT RMHLALQDLQ IFMSKAIEVL LGIRHEKNDQ
PPSQFEPAQS RSKYDAQPVV KAVSAREGTV QTVVLFNPSE QTRNEVVMVT VERPDVTILD
SNWTCIKSQI SPELSHDKRS TLSKRHRVYW KASVPAMGLQ TYYVANGFAG CEKAIPAQLR
ISVSSGNISC PSPYTCSKFE SNEAAIQNEH LTLTFSTKFG LLQKVSHSDG RQNVIDEEID
MYSSTGGAYL FKPEGEAEPI IQAGGIMVIS EGHLVQEVYS YPMTAWDKSP ISHSTRIYNG
HNTIQEHIIE KEYHVELLGH ELNDRELIVR YKTDIENKRI FYSDLNGFQM SRRESYDKIP
TQGNYYPIPS LAFMQGPHGD RFSVHTRQSL GVASLKDGWL EIMLDRRLVR DDGRGLGQGV
MDNRAMNVVF HILVESNVTE ANQTTGPHPL NPSLLSHLVG AHLNYPLHVF IAKKSEEISV
QPPPRSFSPL AASLPCDLHI VNFKVPRPLK YTQQQLEEPR FALVFQRRHW DSSFCRKARS
ECSSVADVPV NLFYMFKNLA VLNAKATSLN LLHDDIEILG YGDHFGDGAH DGHVLISPME
IQAYKLELRP H
//
