ID M0ZNU4_SOLTU Unreviewed; 1152 AA.
AC M0ZNU4;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Nonsense-mediated mRNA decay protein {ECO:0000313|EnsemblPlants:PGSC0003DMT400004711};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400004711, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400004711}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400004711};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01341}.
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DR AlphaFoldDB; M0ZNU4; -.
DR EnsemblPlants; PGSC0003DMT400004711; PGSC0003DMT400004711; PGSC0003DMG400001863.
DR Gramene; PGSC0003DMT400004711; PGSC0003DMT400004711; PGSC0003DMG400001863.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; M0ZNU4; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF499; HELICASE ATP-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 128..287
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..228
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 952..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..979
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1093
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1152 AA; 126854 MW; 8ED4AB8670F02BD8 CRC64;
MDSQSNSLYD TASQPDTGND AYTFLEFNTQ GEEFDYPEFH ELSQPIRSSA WPTPSDSLVS
EAPDRPQSSS DASQASGKSR GGDGGRSSSS KISSNKAAAV AVDALAAGMS GLNFEETGDD
ESFEYGKGDF AVEHACKYCG VTNPACVVRC NVPSCRKWFC NSRGNTSGSH IVNHLVRAKH
KEVCLHKDSP LGETILECYN CGCRNVFLLG FISAKTESVV VLLCREPCLN VNALKDMNWD
LSQWCPLIDD RCFLQWLVKV PSEQEQLRAR QISAQQINKI EELWKTNPDA NLEDLEKPGV
DDEPQPVGLK YEDAYQYQNI FAPLIKLEAD YDKMMKESQS KDNLTVRWDI GLNKKRVAYF
VFPKEDNELR LVPGDELRLR YSGDAAHPAW QSVGHVIKLT AQEEVALELR ASQGVPVDVT
HGLSVDFVWK STSFDRMQTA MKTFAVDETS VSGYIYHHLL GHEVEMQMVR NTVPRRFGAP
GLPELNASQV FAVKSVLQKP VSLIQGPPGT GKTVTSAAIV YHMAKQGQGQ VLVCAPSNVA
VDQLAEKISA TGLKVVRLCA KSREAVSSPV EHLTLHYQVR HLDTSEKSEL YKLQQLKDEQ
GELSSGDEKK YKALKRATER EIAQSADVIC CTCVGAGDPR LANFRFRQVL IDESTQAGEP
ECLIPLVLGA KQIVLVGDHC QLGPVIMCKK AARAGLAQSL FERLVLLGVK PIRLQVQYRM
HPALSEFPSN SFYEGTLQNG VTINERQSLG IDFPWPVPNR PMFFYVQMGQ EEISSSGTSY
LNRTEAASVE KLVTTFLKSG VVPSQIGVIT PYEGQRAYIV NYMSRNGALR QQLYKEIEVA
SVDSFQGREK DYIILSCVRS NEHQGIGFLN DPRRLNVALT RARYGIVILG NPKVLSKQPL
WNGLLTHYKE HECLVEGPLN NLKQSMVQFQ KPKKIYNDRR LFFGGGPGIV PSDNYGSPAS
SNPNADRRSS HSRGSYMAPG PSNGTHRPGV YSSGYPMPRV PISPYHGGPP QPYAIPARDA
IHGPVGAVPH VPHPGNRGFG AGRGNANAPI GSHLSHQQAS QQPIGSHGPN FNFSALENPN
TQPSGGGPLS QPGYASNVSK PVNSFTILSY SYCSSSKHVF LILKIIDGHS RTKPDISRWI
FNGWHVTGFL GR
//
