ID M1A1A6_SOLTU Unreviewed; 874 AA.
AC M1A1A6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Resistance protein PSH-RGH7 {ECO:0000313|EnsemblPlants:PGSC0003DMT400012486};
GN Name=102585304 {ECO:0000313|EnsemblPlants:PGSC0003DMT400012486};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400012486, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400012486}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400012486};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR RefSeq; XP_015168923.1; XM_015313437.1.
DR AlphaFoldDB; M1A1A6; -.
DR PaxDb; 4113-PGSC0003DMT400012486; -.
DR EnsemblPlants; PGSC0003DMT400012486; PGSC0003DMT400012486; PGSC0003DMG400004874.
DR GeneID; 102585304; -.
DR Gramene; PGSC0003DMT400012486; PGSC0003DMT400012486; PGSC0003DMG400004874.
DR KEGG; sot:102585304; -.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_35_4_1; -.
DR InParanoid; M1A1A6; -.
DR OMA; REIRMEV; -.
DR OrthoDB; 761001at2759; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT DOMAIN 175..411
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT COILED 46..80
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 874 AA; 100258 MW; 728291CDCAF44E8D CRC64;
MANAAVISLV RSLEELVQRK PHLISDETRR MVDSVLDSLE YFQDFLESTS KRRQKYCRKV
EELEREIRME VEKAEDVIEL KIMYGIMKKE GLSKTFLRTL VGKIDAPRER KAIRKTLLPF
VKKIDAVKSN VMGSSFGTNQ VQGYDDSTNE DLLPGLSSRN VAKLNPENIV VGLEDDLVRI
IRRLKGPTLT REIIPILGMG GIGKTTLARK AFDDFETRHR FDIRIWVTVS QEYRIKGMLL
DILRCTSDET NEKSNDRLMD MIYKKLKGWR YLVVMDDIWS NDVWDLMTRT FPDDNNGSRI
ILTSRQEEVA NHADPHSNPH KMNLLNSDNS WKLLRDKVFG VEHACPPELE DIGEQVAQRC
QGLPLALLVV AGHLSKISRT QESWKDVAKS VSKVVADESD ICLGVLSMSY NYLPDHLKPC
FLYMGVFPED SVVNIVRLIN LWISEGFISD ELEGRDCLED LVSRNLVMVR NRSFNGEAKT
CGVHDLIRDL ILREAEKEKF LEVTRIHEAA NPSAEKLRSA RRYCFHSCDQ TVFWKLSSII
RTLHFFDGFQ KLSKQVPLLV SFKLLRVLAI LNVTFQTFPL EITKLVQLRY LQFTCYDDIH
WSVSKLHNLQ TFILGYGVAG LLPPTIPAGI WQMSNLRHLH IGDFFSFPIP SNKLQNLQEL
SRLALTSCTS ELFSAIPNLK KLKIIGNYLM EMKRERLNSL SCLKKLEILK YRDDGIQPSQ
IPSKYVLPAS LKRLTLSCTS LPWKDMANVI TLPNLEVLKI KDNGFLGDEW MLNDEEIFKQ
LKFLLISWTG LKHWKAGSVN FPKLQRLFLK RCMNLEKIPQ DFGEICTLES IELHKCSISA
AKSGKDIQEE QESMGNECLS VLIYNHPSSS AQHI
//
