ID M1A861_SOLTU Unreviewed; 729 AA.
AC M1A861;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Tospovirus resistance protein C {ECO:0000313|EnsemblPlants:PGSC0003DMT400016796};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400016796, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400016796}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400016796};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR AlphaFoldDB; M1A861; -.
DR PaxDb; 4113-PGSC0003DMT400016796; -.
DR EnsemblPlants; PGSC0003DMT400016795; PGSC0003DMT400016795; PGSC0003DMG400006570.
DR EnsemblPlants; PGSC0003DMT400016796; PGSC0003DMT400016796; PGSC0003DMG400006570.
DR Gramene; PGSC0003DMT400016795; PGSC0003DMT400016795; PGSC0003DMG400006570.
DR Gramene; PGSC0003DMT400016796; PGSC0003DMT400016796; PGSC0003DMG400006570.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_023895_1_0_1; -.
DR InParanoid; M1A861; -.
DR OMA; NICVAII; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022667};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT DOMAIN 555..722
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 729 AA; 84233 MW; 32064F7873775C0B CRC64;
MKWKLGTVSP KMVQNEIKEM LDHLRWIKSR GNLSRNKIKR IEKLEVVLRV FRTFIEYHHV
DLLHVSLVEL TKKAKSTVEM LQRVLDGIPD ECKTNLNLGR LESHLLKFFQ GNTSLSDNNK
LNDFDLSKYM DCLGKNLNDV LVMVLEGVRF SPPEENLEIH KFIKQLEIVQ KKLKFLIYLY
ATEIKGYVNH EKLECLETRM HFMANNVGQL CLAISGCVVS NFVDDILNKP PYLLFLIVLV
ELEMKKIFRS DLKASKFTHS RTFKDRKLPK GFSHHLHSLL MYLRNKTVEN FPNYSTAQNI
CVAIIEFLVV FLEADVSNHV INGNWLNEAM EKVGAIAGDV LYAIQKVLPR SINKDDTSKM
SLFSIHVLKK TKDLKTQVET YYKSLKFTPS QFPTVGGWSF LDSLIQKLNE MSESKSGLDF
LMKPLLGNLE KELSALTSIL EKDLSSLSSI FRNFAKVHHG NEILQDLHRR TIKLAYEAEV
AIDSILAQYN VFWHIFCSLP TILKEIKQIN VQVTEMCSTD VALKPCYVVA QYKHLPTRHS
NPMTDEEIVG FGNDTEKMIQ YLIRGTNELD VIPIVGMGGQ GKTTIARKLY NSYNIVSHFD
VRAWCIISQT YNRRDLLQDI CSQVTGSKDK GDKDDILADE LRKILMGKRY LIVLDDMWDC
MAWDDLSLCF PDVRNRSRIV VTTRLKKVSE QVKYHTDPYS LPFLTKEESC KLLQKKCFKR
KIARLNYKM
//
