ID M1AEE2_SOLTU Unreviewed; 541 AA.
AC M1AEE2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=AMP dependent CoA ligase {ECO:0000313|EnsemblPlants:PGSC0003DMT400020978};
GN Name=102597265 {ECO:0000313|EnsemblPlants:PGSC0003DMT400020978};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400020978, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400020978}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400020978};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- PATHWAY: Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene
CC biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004930}.
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DR RefSeq; XP_006340129.1; XM_006340067.2.
DR AlphaFoldDB; M1AEE2; -.
DR STRING; 4113.M1AEE2; -.
DR PaxDb; 4113-PGSC0003DMT400020978; -.
DR EnsemblPlants; PGSC0003DMT400020978; PGSC0003DMT400020978; PGSC0003DMG400008122.
DR GeneID; 102597265; -.
DR Gramene; PGSC0003DMT400020978; PGSC0003DMT400020978; PGSC0003DMG400008122.
DR KEGG; sot:102597265; -.
DR eggNOG; KOG1176; Eukaryota.
DR HOGENOM; CLU_000022_59_2_1; -.
DR InParanoid; M1AEE2; -.
DR OMA; ETANVMT; -.
DR OrthoDB; 1404660at2759; -.
DR UniPathway; UPA00372; UER00547.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; M1AEE2; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016207; F:4-coumarate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0016405; F:CoA-ligase activity; IBA:GO_Central.
DR GO; GO:0009698; P:phenylpropanoid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd05904; 4CL; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24096:SF423; 4-COUMARATE--COA LIGASE-LIKE 7; 1.
DR PANTHER; PTHR24096; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phenylpropanoid metabolism {ECO:0000256|ARBA:ARBA00023051};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 93..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..401
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 452..527
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 541 AA; 59437 MW; EF37825795DCD228 CRC64;
MEKSGYGRDG IYRSLRPPLF YPKDENLSMV SFLFRNSSSY PEKPAFFDAD NGETLSFSQF
KSMVSRISHG LIHQMGIKKN DVVLIFAPNS VQFPLSFFGV IAIGAIATTV NPMYTVSELS
KQIKDCKPKL IITSPELFDK VNRFNLPILL LGHPGNSNSN NSGVVRFTEL VGKAGYFDLD
KTVIKQTDTA ALLYSSGTTG VSKGVVLTHR NFISAALMVT SDQELAGEMH NVYLCILPMF
HVFGLAVIMY AQLQRGNAIV SMAKFDLETL LKNVDKYRVS HLWIVPPIVL ALAKNPVVKK
YNLMSIKQIG SGAAPLGKDL MEDCAKNFPQ AVVMQGYGMT ETCGIVSMEN VYAGPRHTGS
AGTLASGVEA QIVSVDKSKP LPPGQLGEIW VRGPNMMKGY FNNPQATKLT IDNQGWVHTG
DLGYFTEDGL LYVVDRIKEL IKYKGFQVAP AELEGLLVSH PEILDAVVIP FPDAEAGEVP
VAYVVRSPNS SLTEENVQKF IADQVAPFKR LKKVTFINSV PKSAAGKILR RELIDKVRSK
I
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