ID M1AKC6_SOLTU Unreviewed; 484 AA.
AC M1AKC6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Hemolysin {ECO:0000313|EnsemblPlants:PGSC0003DMT400024564};
GN Name=102579271 {ECO:0000313|EnsemblPlants:PGSC0003DMT400024564};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400024564, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400024564}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400024564};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_006362677.1; XM_006362615.2.
DR AlphaFoldDB; M1AKC6; -.
DR STRING; 4113.M1AKC6; -.
DR PaxDb; 4113-PGSC0003DMT400024564; -.
DR EnsemblPlants; PGSC0003DMT400024564; PGSC0003DMT400024564; PGSC0003DMG400009496.
DR GeneID; 102579271; -.
DR Gramene; PGSC0003DMT400024564; PGSC0003DMT400024564; PGSC0003DMG400009496.
DR KEGG; sot:102579271; -.
DR eggNOG; KOG2118; Eukaryota.
DR HOGENOM; CLU_011310_0_0_1; -.
DR InParanoid; M1AKC6; -.
DR OMA; TCQPEDE; -.
DR OrthoDB; 248389at2759; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030026; P:intracellular manganese ion homeostasis; IBA:GO_Central.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR12064:SF36; DOMAIN-CONTAINING PROTEIN, PUTATIVE, EXPRESSED-RELATED; 1.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 13..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..192
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 211..272
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 448..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 53128 MW; 23C9CF4679888DF4 CRC64;
MAANDVPCCE TMFWVYLIIC VSLVCFAGLM SGLTLGLMSL SLMDLEILIK AGQPNDRKNA
EKILPIVKNQ HLLLCTLLIC NAMAMEALPI FLDALLPAWG AILISVTLIL AFGEIIPQSI
CSRYGLSIGA RLAPLVRLLV IVVFPLSYPI SKLLDLLLGK GHSALLRRAE LKMLVNMHGN
EAGKGGELSH DETTIIAGAL DLAQKSVKDS MTPMSRVFSL DLHSKLTDEM MNLIISKGHS
RVPVYSGTPT NIVGLILVKN LIKCRPEDEV PIKDLTIRSI PKVPDSLPLY DLLNQFEKGH
SHMAVVVKSR RITKETAENA TAKHDIIKIN ILPASPIQQL HAFEKGEEAI GIITMEDVLE
QLLQEPIYDE TDDYVDVHNK IRINIPPSMI FSPRRSPGAV ATGATNYKPK WQSPIASPVH
SSAHQSPMLR SPVSPYVQSP YIVPKLSPAH LNSTNSPSRF SRSSPSSNDQ VSLKSYEKLD
KHGL
//
