ID M1ALN6_SOLTU Unreviewed; 431 AA.
AC M1ALN6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=RNA pseudourine synthase 2, chloroplastic {ECO:0000313|EnsemblPlants:PGSC0003DMT400025583};
GN Name=102581156 {ECO:0000313|EnsemblPlants:PGSC0003DMT400025583};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400025583, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400025583}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400025583};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in RNA = a pseudouridine in RNA;
CC Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|ARBA:ARBA00000073};
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000256|ARBA:ARBA00010876}.
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DR RefSeq; XP_006342081.1; XM_006342019.2.
DR AlphaFoldDB; M1ALN6; -.
DR STRING; 4113.M1ALN6; -.
DR PaxDb; 4113-PGSC0003DMT400025583; -.
DR EnsemblPlants; PGSC0003DMT400025583; PGSC0003DMT400025583; PGSC0003DMG400009884.
DR GeneID; 102581156; -.
DR Gramene; PGSC0003DMT400025583; PGSC0003DMT400025583; PGSC0003DMG400009884.
DR KEGG; sot:102581156; -.
DR eggNOG; KOG1919; Eukaryota.
DR HOGENOM; CLU_016902_4_3_1; -.
DR InParanoid; M1ALN6; -.
DR OMA; KSERAYT; -.
DR OrthoDB; 5479603at2759; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; M1ALN6; baseline.
DR GO; GO:0009982; F:pseudouridine synthase activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IBA:GO_Central.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF44; PSEUDOU_SYNTH_2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55174; Alpha-L RNA-binding motif; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182}.
FT DOMAIN 71..136
FT /note="RNA-binding S4"
FT /evidence="ECO:0000259|SMART:SM00363"
SQ SEQUENCE 431 AA; 46969 MW; FF5C5E3B80B0B2AD CRC64;
MLALNTTSFS LLPQNPKPFS LSRVSSFICR AFTKFPGDSD SDDSPDEIPG RRSNYSGVKL
EETVDGKTGK LRLDSWVSSR IDGVSRARVQ SSIRSGLVSV NGRVTDKVSH MVKGGDKVDC
TIADLKPLRA EPEDIPLDIV FEDEHVLVVN KPAHMVVHPA PGNATGTLVS GILHHCSLPT
ISFLGEEVLS DAEDASDDEL NVFSGNRSPN YDDSSVMCES SVRPGIVHRL DKGTSGLLVV
AKNENSLASL AEQFKKHTIK RVYVSITCGV PASVAGRVDI PIGRDSNNRI RMAAIPGTPK
SGKSRHAVSR YKVIEKLARG GSALVEWRLE TGRTHQIRAH AKYLGIPLMG DEVYGGTKNM
ALSLLQPKTP PMFHGKLSQL VSQIDRPCLH ALTLGFRHPF TGENIHFTRL PPPDFAEILS
YLRAINTEKV L
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