ID M1AZF6_SOLTU Unreviewed; 1254 AA.
AC M1AZF6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Cc-nbs-lrr resistance protein {ECO:0000313|EnsemblPlants:PGSC0003DMT400033636};
GN Name=102582108 {ECO:0000313|EnsemblPlants:PGSC0003DMT400033636};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400033636, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400033636}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400033636};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR RefSeq; XP_006356903.1; XM_006356841.2.
DR RefSeq; XP_015168659.1; XM_015313173.1.
DR AlphaFoldDB; M1AZF6; -.
DR PaxDb; 4113-PGSC0003DMT400033635; -.
DR EnsemblPlants; PGSC0003DMT400033635; PGSC0003DMT400033635; PGSC0003DMG400012918.
DR EnsemblPlants; PGSC0003DMT400033636; PGSC0003DMT400033636; PGSC0003DMG400012918.
DR GeneID; 102582108; -.
DR Gramene; PGSC0003DMT400033635; PGSC0003DMT400033635; PGSC0003DMG400012918.
DR Gramene; PGSC0003DMT400033636; PGSC0003DMT400033636; PGSC0003DMG400012918.
DR KEGG; sot:102582108; -.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_8_8_1; -.
DR InParanoid; M1AZF6; -.
DR OMA; PKDYFFE; -.
DR OrthoDB; 1025058at2759; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT DOMAIN 10..92
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 161..401
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT COILED 35..86
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1254 AA; 142406 MW; 05F865667C1E21E5 CRC64;
MAEVLLSASV EVLLQKLLLL ATNCNSHLWG SKKELENLRR CLAMARAVLH DAERQQRKDQ
AVKLWLKKLE DLAYDADNLL DELNHTTLKK SEWKVCFVLS LPNPLSCKMR AKIREIIVNL
KMINEEANDF AIPRGVEDGI NHINHKETDC FHGDSNIVGR EDDVSTMVES LICQTNQVVA
VFPIVGMGGL GKTTLARLIY NDEQIVRYFD ERIWVCVSEN FDVNKIIRLV LESLTQRSID
VQSRNALLQI LHKELGGRKY LLVLDDVWNE KLEEWDDFKR SLVGINATKG NAIIVTTRSE
RVASIVATHH LHFLEKLSED DCWSVFKERA FPEGDVPMEL VPIGKQIAHK CSGLPLAANL
LGGMLRLTKE TSEWSLVLRN GLWNLNGDEN AVLQVLKLSF DHLPSTSVKK CFAYCSIFSR
DHDIEKDQLV QLWMAEGFLQ LSQGDHLKME SLGNEFFNIL LQNSLLQDVK RDDYGNITHC
KMHSHVHALA QSISRYEGFN IGCSTEDGHP HVRYLSMKSL RESMPSVVKE RARSLRTLFL
ADNVSGSMLS NFKYLRVLSF HGVDVAEVPS SISKLIHLRY LDLSGTKIRA LADSLCMLFN
LQTLRLNGCD FLESIPSQLS KLKNLRHLHY YSFDATCLMP FKMGQLTCLQ TLQFFNVGYA
DGQQIGEIGF LKELGGDLEI RNLEKVTNQQ EARSADLCRK ENIYKLIFQW SSGRQDTVND
DSVLGGLEPH PNLKSLTVQN FMGDKLPTWI MTMMVSTIEG HLLGLDNLVE IKLKGCRKCE
ELPMLGHLPH LKYLDLTGLD NLKTINRSFY GRDFLRSRTY QGDNTNIASF RSLKRLVFCN
MPNLVEWTEP EEVTTEKVFP HLEEIEIHNC SQLTTTPCSF PSLEELRISN VSSYQPLENI
CSSDNSSGLT FLHIDGLLEL ACLPDNLLNN VKNLVYLAIY KCPNLVHVVP RVRGFGSFLR
VLDIKECTNL STLPDDLQTL QSLAMLWISR CPKITSIPSL EGLTTLEELR ISYCDELASL
PNEMLLSCMS LKSLSIENCV NLTSFPNLKQ LHSLLSLRIV DCPQLTCLPK GLHSLSCLNY
LRIGPFSEDL TSFPILDYED APNSEIHEEN LQLFSLRSLT LFGRPHWDSL PAWLQSLSSL
AELHLYDFGF EAVPEWIKNM SSLERLGLYW CEKVSFLPSI EATKCLVKLR EVEIYNCPLL
SERCSSLSGS NSEWSKISHI NQIKVDGKQI TSEATYEVLP SPTLTKKEKK RRKK
//
