ID M1B3P2_SOLTU Unreviewed; 542 AA.
AC M1B3P2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Disease resistance protein R3a {ECO:0000313|EnsemblPlants:PGSC0003DMT400036467};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400036467, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400036467}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400036467};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR AlphaFoldDB; M1B3P2; -.
DR PaxDb; 4113-PGSC0003DMT400036467; -.
DR EnsemblPlants; PGSC0003DMT400036467; PGSC0003DMT400036467; PGSC0003DMG400014047.
DR Gramene; PGSC0003DMT400036467; PGSC0003DMT400036467; PGSC0003DMG400014047.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_9_0_1; -.
DR InParanoid; M1B3P2; -.
DR OMA; ICATIDT; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1237; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1-RELATED; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT DOMAIN 11..105
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 176..416
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT COILED 43..94
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 542 AA; 61565 MW; 0C60F2837F402E78 CRC64;
MDIGLAVGGA FLSSALNVLF DRLAPKGDLL KMFQKHTNDF RILKKLRMTL LGLQAVLSDA
ENKQASNQSV SQWVDELRDA VDSAENLTEE INYEALRLKV EGQHQNLAEV SDLNLCLSDD
FFLNIKEKLE DTIETLKDLQ EQIGLLGLKE HFGSIKQEAR TPSTSLVDDS DIFGRQTNIE
ELIDRLLSED ANGKKLTVVS IVGMGGVGKT TLSKVVYNDE KVKDHFDLKA WFCVSEAYDA
FRITKGLLQE IGSFDLKVDD NLNQLQVKWK ESLKGKKFLI VLDDVWNDNY NEWDDLRNLF
VQGDIGSKII VTTRKESVAL MMANEQISLD NLSIEVSWSL FKRHAFENMD PMGHPELEEV
GKQIAAKCKG LPLALKTLAG MLRSKSEVEG WKRILRSEIW ELPHNNILPA LMLSYNDLPA
HLKRCFSYCA IFPKDYAFRK EQVIHLLVAN GLILQEDRII QDSGNQYFLE LRSRSLFERV
PNPSQGNIEK FLMHDLVNDL AQIASSKLCI RLEESQGSHM LEKGRHLSYS MESIDFEKLT
PL
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