ID M1BE03_SOLTU Unreviewed; 443 AA.
AC M1BE03;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Eukaryotic translation initiation factor {ECO:0000313|EnsemblPlants:PGSC0003DMT400043059};
GN Name=102587245 {ECO:0000313|EnsemblPlants:PGSC0003DMT400043059};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400043059, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400043059}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400043059};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eIF-2-beta/eIF-5 family.
CC {ECO:0000256|ARBA:ARBA00010397}.
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DR RefSeq; XP_006364028.1; XM_006363966.2.
DR AlphaFoldDB; M1BE03; -.
DR STRING; 4113.M1BE03; -.
DR PaxDb; 4113-PGSC0003DMT400043059; -.
DR EnsemblPlants; PGSC0003DMT400043059; PGSC0003DMT400043059; PGSC0003DMG400016697.
DR GeneID; 102587245; -.
DR Gramene; PGSC0003DMT400043059; PGSC0003DMT400043059; PGSC0003DMG400016697.
DR KEGG; sot:102587245; -.
DR eggNOG; KOG2767; Eukaryota.
DR HOGENOM; CLU_026663_1_1_1; -.
DR InParanoid; M1BE03; -.
DR OMA; CMHQAHL; -.
DR OrthoDB; 5475947at2759; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; M1BE03; baseline and differential.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0071074; F:eukaryotic initiation factor eIF2 binding; IBA:GO_Central.
DR GO; GO:0005092; F:GDP-dissociation inhibitor activity; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IBA:GO_Central.
DR GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR CDD; cd11561; W2_eIF5; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.20.25.350; -; 1.
DR Gene3D; 3.30.30.170; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045196; IF2/IF5.
DR InterPro; IPR002735; Transl_init_fac_IF2/IF5_dom.
DR InterPro; IPR016189; Transl_init_fac_IF2/IF5_N.
DR InterPro; IPR016190; Transl_init_fac_IF2/IF5_Zn-bd.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23001; EUKARYOTIC TRANSLATION INITIATION FACTOR; 1.
DR PANTHER; PTHR23001:SF39; EUKARYOTIC TRANSLATION INITIATION FACTOR 5-LIKE; 1.
DR Pfam; PF01873; eIF-5_eIF-2B; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00653; eIF2B_5; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF100966; Translation initiation factor 2 beta, aIF2beta, N-terminal domain; 1.
DR SUPFAM; SSF75689; Zinc-binding domain of translation initiation factor 2 beta; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT DOMAIN 267..443
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 144..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 443 AA; 49246 MW; F4199027452F043B CRC64;
MALQNIGASN RDDAFYRYKM PRMLTKIEGR GNGIKTNVVN MVDIAKALAR PPSYTTKYFG
NELGAQSKFD EKSGTALVNG AHETPKLAGL LENFIKKYVQ CYGCGNPETE VIITKTQMIQ
LKCAACGFLS DVDMRDKLTT FILKNPPETK KGSKDKKAMR RAEKERLKEG EAADEELKKL
KKETKKKVSS KDASTKPSSK KKHGSSDEDR ASPPRSHVNV KEEEDEDDDD DVQWQTDTSL
EAAQQRIQEQ LNTATAEMVM LSTVESEKKK SKALSPKAAS VTPEISKTEN GVTNHERLVG
EIKTNLAKGV IASKLQSFLG SLSGSPQEVI TALYEALLDG VEKGFAKEVI KKKSYLAAIA
QDEESQLRLL QAIEEFSGKS NSVALKEVAL VLKALYDDDL LEEEYIVQWY NKGVTANKDS
KIWKNVKPFV EWLQSAESES EEE
//
