ID M1C5E3_SOLTU Unreviewed; 645 AA.
AC M1C5E3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=methionine--tRNA ligase {ECO:0000256|ARBA:ARBA00012838};
DE EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
GN Name=102605729 {ECO:0000313|EnsemblPlants:PGSC0003DMT400060209};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400060209, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400060209}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400060209};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|RuleBase:RU363039}.
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DR AlphaFoldDB; M1C5E3; -.
DR STRING; 4113.M1C5E3; -.
DR PaxDb; 4113-PGSC0003DMT400060209; -.
DR EnsemblPlants; PGSC0003DMT400060209; PGSC0003DMT400060209; PGSC0003DMG400023422.
DR Gramene; PGSC0003DMT400060209; PGSC0003DMT400060209; PGSC0003DMG400023422.
DR eggNOG; KOG0436; Eukaryota.
DR InParanoid; M1C5E3; -.
DR OMA; NMFLPDR; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; M1C5E3; baseline.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004825; F:methionine-tRNA ligase activity; IBA:GO_Central.
DR GO; GO:0006431; P:methionyl-tRNA aminoacylation; IBA:GO_Central.
DR CDD; cd07957; Anticodon_Ia_Met; 1.
DR CDD; cd00814; MetRS_core; 1.
DR Gene3D; 2.170.220.10; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR HAMAP; MF_01228; Met_tRNA_synth_type2; 1.
DR InterPro; IPR041872; Anticodon_Met.
DR InterPro; IPR014758; Met-tRNA_synth.
DR InterPro; IPR023457; Met-tRNA_synth_2.
DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR InterPro; IPR033911; MetRS_core.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR NCBIfam; TIGR00398; metG; 1.
DR PANTHER; PTHR43326:SF1; METHIONINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43326; METHIONYL-TRNA SYNTHETASE; 1.
DR Pfam; PF19303; Anticodon_3; 1.
DR Pfam; PF09334; tRNA-synt_1g; 1.
DR PRINTS; PR01041; TRNASYNTHMET.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363039};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363039};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363039};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT DOMAIN 212..439
FT /note="Methionyl/Leucyl tRNA synthetase"
FT /evidence="ECO:0000259|Pfam:PF09334"
FT DOMAIN 457..561
FT /note="Methionyl-tRNA synthetase anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF19303"
FT REGION 620..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 645 AA; 71653 MW; 922A365F9050E9FF CRC64;
MACRVQHSIQ SSFWFLSSAP LRNSLNPRRI FFKNRISFGK ELFFSSSSRT ALYCTCSSSS
SSGGDKDGFL ANGVGGDDSF VLTTPLYYVN APPHMGSAYT TIAADAIARF QRLLEKKVIF
ITGTDEHGEK IATAAAANGS SPNEHCDVVS QAYKSLWKDL DISYDKFIRT TDPKHEAVVK
EFYSRVLANG DIYRADYEGL YCVNCEEYKD EKDLLDDNCC PTHLKPCVKR KEDNYFFALS
KYQQQLEEVL KQNPGFVQPS YRLNEVQGWI KNGLKDFSIS RASVDWGIAV PNDSKQTIYV
WFDALLGYVS ALLEDSELAS LDTAISSGWP ASLHLIGKDI LRFHAVYWPA MLMSAGIGLP
KMVFGHGFLT KDGMKMGKSL GNTLEPTDLV QRFGSDAVRY FFLREVEFGN DGDYSEERFI
RMINANLANT IGNLLNRTLG LLKKNCQSTL AVDSDIAAEG NEFKAAVEKL VEKACVHYQK
LELSAACETV LEIGNAGNLY IDGQAPWTLF KQGGTAFETA AKDLVIVLEA MRIISIALSP
ITPRLSLKIY SQLGYTEEQF NAVSWVHSSF FCYIFDDFLA KPLSDRLSCF QSDTKWGGLK
AGQVMAQAAP IFARIEDGTE AETKSATTKK VKKEKTPKSK SPVEA
//
