ID M1CPV6_SOLTU Unreviewed; 299 AA.
AC M1CPV6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=methenyltetrahydrofolate cyclohydrolase {ECO:0000256|ARBA:ARBA00012776};
DE EC=3.5.4.9 {ECO:0000256|ARBA:ARBA00012776};
GN Name=102585419 {ECO:0000313|EnsemblPlants:PGSC0003DMT400072216};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400072216, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400072216}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400072216};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
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DR RefSeq; XP_006339252.1; XM_006339190.2.
DR RefSeq; XP_015165727.1; XM_015310241.1.
DR AlphaFoldDB; M1CPV6; -.
DR STRING; 4113.M1CPV6; -.
DR PaxDb; 4113-PGSC0003DMT400072216; -.
DR EnsemblPlants; PGSC0003DMT400072216; PGSC0003DMT400072216; PGSC0003DMG402028101.
DR GeneID; 102585419; -.
DR Gramene; PGSC0003DMT400072216; PGSC0003DMT400072216; PGSC0003DMG402028101.
DR KEGG; sot:102585419; -.
DR eggNOG; KOG0089; Eukaryota.
DR HOGENOM; CLU_034045_1_2_1; -.
DR InParanoid; M1CPV6; -.
DR OMA; VCHILTK; -.
DR OrthoDB; 5386942at2759; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; M1CPV6; baseline.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IBA:GO_Central.
DR GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IBA:GO_Central.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IBA:GO_Central.
DR CDD; cd01080; NAD_bind_m-THF_DH_Cyclohyd; 1.
DR Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR HAMAP; MF_01576; THF_DHG_CYH; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000672; THF_DH/CycHdrlase.
DR InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR InterPro; IPR020867; THF_DH/CycHdrlase_CS.
DR InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR PANTHER; PTHR48099:SF27; BIFUNCTIONAL PROTEIN FOLD 2; 1.
DR PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR Pfam; PF00763; THF_DHG_CYH; 1.
DR Pfam; PF02882; THF_DHG_CYH_C; 1.
DR PRINTS; PR00085; THFDHDRGNASE.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00766; THF_DHG_CYH_1; 1.
DR PROSITE; PS00767; THF_DHG_CYH_2; 1.
PE 3: Inferred from homology;
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT DOMAIN 12..127
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00763"
FT DOMAIN 130..295
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF02882"
SQ SEQUENCE 299 AA; 32163 MW; 45B4D591F18461F5 CRC64;
MASPSDHKAT IIDGKAIAQT IRSEIASEVQ RLSEKYGKVP GLAVVIVGNR KDSQSYVNMK
RKSCAELCIK SFDIDLPEDV SEAEVISKVH ELNANPDVHG ILVQLPLPKH ISEEKVLCEI
SLEKDVDGFH PLNIGKLAMK GRQPLFNPCT PRGCIELLVR SGISIKGKNA VVVGRSNIVG
LPVSLLLLKE DATVTVVHSR TKEPEKIIRE ADIIIAAAGQ AMMIKGSWIK PGAAVLDVGT
NAVDDPTRKS GYRLVGDVDF QEACKVAGWI TPVPGGVGPM TVAMLLKNTL DGAKRVIEK
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