ID M1D260_SOLTU Unreviewed; 485 AA.
AC M1D260;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 67.
DE RecName: Full=FK506-binding protein {ECO:0000256|PIRNR:PIRNR001473};
DE EC=5.2.1.8 {ECO:0000256|PIRNR:PIRNR001473};
GN Name=102579636 {ECO:0000313|EnsemblPlants:PGSC0003DMT400079626};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400079626, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400079626}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400079626};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8;
CC Evidence={ECO:0000256|ARBA:ARBA00000971,
CC ECO:0000256|PIRNR:PIRNR001473, ECO:0000256|PROSITE-ProRule:PRU00277};
CC -!- SIMILARITY: Belongs to the FKBP-type PPIase family.
CC {ECO:0000256|PIRNR:PIRNR001473}.
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DR RefSeq; XP_006348066.1; XM_006348004.2.
DR AlphaFoldDB; M1D260; -.
DR STRING; 4113.M1D260; -.
DR PaxDb; 4113-PGSC0003DMT400079626; -.
DR EnsemblPlants; PGSC0003DMT400079626; PGSC0003DMT400079626; PGSC0003DMG400031007.
DR GeneID; 102579636; -.
DR Gramene; PGSC0003DMT400079626; PGSC0003DMT400079626; PGSC0003DMG400031007.
DR KEGG; sot:102579636; -.
DR eggNOG; KOG0552; Eukaryota.
DR HOGENOM; CLU_022297_1_1_1; -.
DR InParanoid; M1D260; -.
DR OMA; GESEDCC; -.
DR OrthoDB; 317095at2759; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; M1D260; baseline.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:GO_Central.
DR Gene3D; 3.10.50.40; -; 1.
DR Gene3D; 2.60.120.340; Nucleoplasmin core domain; 1.
DR InterPro; IPR041232; NPL.
DR InterPro; IPR036824; Nucleoplasmin_core_dom_sf.
DR InterPro; IPR046357; PPIase_dom_sf.
DR InterPro; IPR001179; PPIase_FKBP_dom.
DR InterPro; IPR023566; PPIase_Fpr3/Fpr4-like.
DR PANTHER; PTHR43811:SF19; 39 KDA FK506-BINDING NUCLEAR PROTEIN; 1.
DR PANTHER; PTHR43811; FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA; 1.
DR Pfam; PF00254; FKBP_C; 1.
DR Pfam; PF17800; NPL; 1.
DR PIRSF; PIRSF001473; FK506-bp_FPR3; 2.
DR SUPFAM; SSF54534; FKBP-like; 1.
DR SUPFAM; SSF69203; Nucleoplasmin-like core domain; 1.
DR PROSITE; PS50059; FKBP_PPIASE; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|PIRNR:PIRNR001473, ECO:0000256|PROSITE-
KW ProRule:PRU00277}; Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW Rotamase {ECO:0000256|PIRNR:PIRNR001473, ECO:0000256|PROSITE-
KW ProRule:PRU00277}.
FT DOMAIN 397..485
FT /note="PPIase FKBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50059"
FT REGION 104..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..142
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..366
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 53613 MW; 4AFD4814B834E8EF CRC64;
MAFWGVELKS GKPFTHNFEK ERGRLHISQA TLGSGSSNKK SIVQCKVGDK EPIYVCSLLP
EKLETCPLNL EFEEDEDVTF SVIGSHNVHL SGFFYGESED CCGDEHGSDY EEGASETDSA
SDDSFEFNYD TEDEDEDGST DNDDFIMYPP SPIPNSGVRI EEILEDEKPT DENGTSKKPK
KKKNQSKGID DSERQIVVKG NTDSPQMESE DEDGFPISAP SENKTKSVRS QKSDGTKDQD
TGEEAGEKKG LKKRLRDDTG KANDQQREDN AKQNKKNKKK KVVDGEESVR EDVLKSSANP
EHVEGNDEAV SVGKTEDGQK PTNEKDTEKK KKKKKNKKNQ QDGEAVTEVE KDKKNESHEV
QEENAGTKPS HARTFGNGLV IEELAMGKPD GKKASPGKKV GVRYTGKLKK NGKIFDSNIG
KRPFEFRLGI GQVIKGWDVG VNGMRVGDKR RITIPPAMGY GAKGAGRDIP PNSWLVFDVE
LVNVN
//
