ID   M1D3S7_SOLTU            Unreviewed;       903 AA.
AC   M1D3S7;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=NRC1 {ECO:0000313|EnsemblPlants:PGSC0003DMT400080647};
GN   Name=102605241 {ECO:0000313|EnsemblPlants:PGSC0003DMT400080647};
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400080647, ECO:0000313|Proteomes:UP000011115};
RN   [1] {ECO:0000313|Proteomes:UP000011115}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX   PubMed=21743474; DOI=10.1038/nature10158;
RG   The Potato Genome Sequencing Consortium;
RT   "Genome sequence and analysis of the tuber crop potato.";
RL   Nature 475:189-195(2011).
RN   [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400080647}
RP   IDENTIFICATION.
RC   STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400080647};
RG   EnsemblPlants;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000256|ARBA:ARBA00008894}.
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DR   AlphaFoldDB; M1D3S7; -.
DR   STRING; 4113.M1D3S7; -.
DR   PaxDb; 4113-PGSC0003DMT400080647; -.
DR   EnsemblPlants; PGSC0003DMT400080647; PGSC0003DMT400080647; PGSC0003DMG400031405.
DR   Gramene; PGSC0003DMT400080647; PGSC0003DMT400080647; PGSC0003DMG400031405.
DR   eggNOG; KOG4658; Eukaryota.
DR   InParanoid; M1D3S7; -.
DR   OMA; ANIWNME; -.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   ExpressionAtlas; M1D3S7; baseline and differential.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.20.5.4130; -; 1.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR041118; Rx_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR   PANTHER; PTHR23155:SF1193; DISEASE RESISTANCE PROTEIN RPP13-RELATED; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF18052; Rx_N; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT   DOMAIN          5..91
FT                   /note="Disease resistance N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18052"
FT   DOMAIN          180..417
FT                   /note="NB-ARC"
FT                   /evidence="ECO:0000259|Pfam:PF00931"
SQ   SEQUENCE   903 AA;  103234 MW;  B4046DEDDF06D83C CRC64;
     MANVAVEFLV ENLMQLLRDN AELISGVKEA AESLLQDLND FNAFLKQAAK CHINENEVLR
     ELVKKIRTVV NSAEDAIDKF VIEAKLHKDK GMTRVLDLPH YKRVREVAGE IKAIRNKVKE
     IRQNDAIGLQ ALQDDDSSAR GFEERKLLLV HISNIYLGCI NLKPPVVEED DVVGFDEEAD
     IVIKRLLGES NRLEVVPVVG MPGLGKTTLA NKIYKHPKIG YEFFTRIWVY VSQSYRRREL
     FLNIISKFTR NTKQYHGMCE EDLADEIQEF LGKGGKYLVV LDDVWSDEAW ERIKIAFPNN
     NKPNRVLLTT RDSKVAKQCT PIPHDLKFLS EDESWILLEK KVFHKDKCPP ELVVPSGKSI
     AKKCKGLPLA IVVIAGALIG KGKTPREWKQ VDDSVSEHLI NRDHPENCNK LVQMSYDRLP
     YDLKACFLYC SAFPGGFQIP AWKLIRLWIA EGFIQYKGHL SLECKGEDNL NDLINRNLVM
     VMERTSDGQI KTCRLHDMLH EFCRQEAMKE ENLFQEIKLG SEQYFPGKRE LSTYRRLCIH
     SSVLDFISTK PSAEHVRSFL SFSSKKIEMP SADIPTIPKG FPLLRVLDVE SINFSRFSKE
     FYQLYHLRYV AFSSDSIKIL PKLMGELWNI QTIIINTQQR TLDIQANIWN MERLRHLHTN
     SSAKLPVPVA PKNSKVTLVN QSLQTLSTIA PESCTEEVFA RTPNLKKLGI RGKIAVLLDN
     KSAVSLKNVK RLEYLENLKL INDSSIQTGK LRLPPAYIFP TKLRKLTLLD TWLEWKDMSI
     LGQLEHLEVL KMKENGFTGE SWESTGGFCS LLVLWIERTN LVTWKASADD FPRLKHLVLI
     CCDYLKEVPI ALADIRSFQV MMLQNSTKTA AISARQIQAK KDNQTQQGTK NIAFKLSIFP
     PDL
//