ID   M1D3S8_SOLTU            Unreviewed;       886 AA.
AC   M1D3S8;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=NRC1 {ECO:0000313|EnsemblPlants:PGSC0003DMT400080649};
GN   Name=102605241 {ECO:0000313|EnsemblPlants:PGSC0003DMT400080649};
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400080649, ECO:0000313|Proteomes:UP000011115};
RN   [1] {ECO:0000313|Proteomes:UP000011115}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX   PubMed=21743474; DOI=10.1038/nature10158;
RG   The Potato Genome Sequencing Consortium;
RT   "Genome sequence and analysis of the tuber crop potato.";
RL   Nature 475:189-195(2011).
RN   [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400080649}
RP   IDENTIFICATION.
RC   STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400080649};
RG   EnsemblPlants;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000256|ARBA:ARBA00008894}.
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DR   RefSeq; XP_006359790.1; XM_006359728.2.
DR   AlphaFoldDB; M1D3S8; -.
DR   EnsemblPlants; PGSC0003DMT400080649; PGSC0003DMT400080649; PGSC0003DMG400031405.
DR   GeneID; 102605241; -.
DR   Gramene; PGSC0003DMT400080649; PGSC0003DMT400080649; PGSC0003DMG400031405.
DR   KEGG; sot:102605241; -.
DR   HOGENOM; CLU_000837_35_4_1; -.
DR   OrthoDB; 759159at2759; -.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   ExpressionAtlas; M1D3S8; baseline and differential.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.20.5.4130; -; 1.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR041118; Rx_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR   PANTHER; PTHR23155:SF1193; DISEASE RESISTANCE PROTEIN RPP13-RELATED; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF18052; Rx_N; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT   DOMAIN          5..91
FT                   /note="Disease resistance N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18052"
FT   DOMAIN          163..400
FT                   /note="NB-ARC"
FT                   /evidence="ECO:0000259|Pfam:PF00931"
SQ   SEQUENCE   886 AA;  101325 MW;  EE7D44F0CB4357EA CRC64;
     MANVAVEFLV ENLMQLLRDN AELISGVKEA AESLLQDLND FNAFLKQAAK CHINENEVLR
     ELVKKIRTVV NSAEDAIDKF VIEAKLHKDK GMTRVLDLPH YKRVREVAGE IKAIRNKVKE
     IRQNDAIGLQ ALQDDDSSAR GFEERKPPVV EEDDVVGFDE EADIVIKRLL GESNRLEVVP
     VVGMPGLGKT TLANKIYKHP KIGYEFFTRI WVYVSQSYRR RELFLNIISK FTRNTKQYHG
     MCEEDLADEI QEFLGKGGKY LVVLDDVWSD EAWERIKIAF PNNNKPNRVL LTTRDSKVAK
     QCTPIPHDLK FLSEDESWIL LEKKVFHKDK CPPELVVPSG KSIAKKCKGL PLAIVVIAGA
     LIGKGKTPRE WKQVDDSVSE HLINRDHPEN CNKLVQMSYD RLPYDLKACF LYCSAFPGGF
     QIPAWKLIRL WIAEGFIQYK GHLSLECKGE DNLNDLINRN LVMVMERTSD GQIKTCRLHD
     MLHEFCRQEA MKEENLFQEI KLGSEQYFPG KRELSTYRRL CIHSSVLDFI STKPSAEHVR
     SFLSFSSKKI EMPSADIPTI PKGFPLLRVL DVESINFSRF SKEFYQLYHL RYVAFSSDSI
     KILPKLMGEL WNIQTIIINT QQRTLDIQAN IWNMERLRHL HTNSSAKLPV PVAPKNSKVT
     LVNQSLQTLS TIAPESCTEE VFARTPNLKK LGIRGKIAVL LDNKSAVSLK NVKRLEYLEN
     LKLINDSSIQ TGKLRLPPAY IFPTKLRKLT LLDTWLEWKD MSILGQLEHL EVLKMKENGF
     TGESWESTGG FCSLLVLWIE RTNLVTWKAS ADDFPRLKHL VLICCDYLKE VPIALADIRS
     FQVMMLQNST KTAAISARQI QAKKDNQTQQ GTKNIAFKLS IFPPDL
//