ID M1D6X4_SOLTU Unreviewed; 868 AA.
AC M1D6X4;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400083471, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400083471}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400083471};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR AlphaFoldDB; M1D6X4; -.
DR EnsemblPlants; PGSC0003DMT400083471; PGSC0003DMT400083471; PGSC0003DMG400033334.
DR Gramene; PGSC0003DMT400083471; PGSC0003DMT400083471; PGSC0003DMG400033334.
DR HOGENOM; CLU_001561_0_2_1; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; M1D6X4; baseline.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11017:SF393; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00560; LRR_1; 3.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 2.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 3..212
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 707..833
FT /note="C-JID"
FT /evidence="ECO:0000259|Pfam:PF20160"
FT REGION 837..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..854
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 868 AA; 100530 MW; 8C30BEAB3CE24179 CRC64;
MEINDVRIVW IWGMGGIGKT TLAKTIFYKL SSQFEINDVC FLENIKEKKH KMHSLQNILL
SKLLREKDNC VKDKEEGRNL LATRLKCKKV LIVLDDIDHG DQMEYLANDL GWFDKGSRII
ATTRDQRLIG ENHVVYEMET LLDRDAIKLF ELYAFKKKVP NECFKDLTLE IVSLAKGHPL
ALKVWGSSLH RMDITEWKSA MVRIKKNSNV EITKNLKISY DGLEREEQQI FLDIACFFRG
IEKEEVMQVL ESCYFGPKFG LRVLVNKSLV SISEYDTIEM HDLIQDMGKY IVQRRKHPEK
HSRLWNVEHF NEVVDNNMGT MPVKAIWFTY CQQQSFNKEA MKNMTRLRIL CIRGDKYDLF
FSSDSNSHDG STDGSIEYLS NNLRWFVWHE YPWKLLPRNF EPKKLVHLEL RWSSLHYLWN
ETKLEKFLSL RRIDLRDSKS LKRTPDFKGM PNLEYLNLAC CTSLEEVHPS LKYCKKLIRL
DLFDCRSLER FPYVNVESLD FFILDYCRSL KKFPEILGIM KTELEISMSC SGIRELPLSN
FDLQPHLTKL DLSGMEYLVS LPSIICKLKG LVKLDLSRCS KLKSLPEDIG SLSSLKKLDL
SYCNIIDGGL PEDIGSLSSL QRLNLSGNNF EHLPQSISEL GALRSLNLSD CNRLTQLPEF
PQNLNTIFAN WSNDWICNSL FQNISSLQHD ICSSHSLSLR VLVSWVVDIP SWFNYKGTDT
KVSVNLPENW YVSDNFLGFA VCYYGDYYID CITAHLIPLC DDGMSSMTQE FSLSNNSKYS
DVWNINFFLI PLGGLWDASN ANGKTPNDYG CISLIFGKEK KFGFRLLYKD EAELHNAKRR
SRNEHHEEEA SCSSSKKQRP LFPTSSGL
//
