ID   M1HLN3_9CAUD            Unreviewed;       611 AA.
AC   M1HLN3;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Adenylate/guanylyl cyclase {ECO:0000313|EMBL:AGE60353.1};
OS   Pelagibacter phage HTVC008M.
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes.
OX   NCBI_TaxID=1283076 {ECO:0000313|EMBL:AGE60353.1, ECO:0000313|Proteomes:UP000011298};
RN   [1] {ECO:0000313|EMBL:AGE60353.1, ECO:0000313|Proteomes:UP000011298}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23407494; DOI=10.1038/nature11921;
RA   Zhao Y., Temperton B., Thrash J.C., Schwalbach M.S., Vergin K.L.,
RA   Landry Z.C., Ellisman M., Deerinck T., Sullivan M.B., Giovannoni S.J.;
RT   "Abundant SAR11 viruses in the ocean.";
RL   Nature 494:357-360(2013).
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DR   EMBL; KC465899; AGE60353.1; -; Genomic_DNA.
DR   RefSeq; YP_007517885.1; NC_020484.1.
DR   GeneID; 14697609; -.
DR   KEGG; vg:14697609; -.
DR   Proteomes; UP000011298; Genome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR007890; CHASE2.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF05226; CHASE2; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM01080; CHASE2; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011298};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        308..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        331..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        361..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          423..559
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   611 AA;  68553 MW;  C0067FE8B648DC58 CRC64;
     MKYLTHWLTA FVTVVLLTYV GLQDPGFKET LRLKSFDYLL ANEERTPSQD ITILTIDEQA
     IEKYGQWPWP RKVLADIIIK LRQNDTGIIV MPILFSERDR FDGDMDFCET LTYGTVIAQV
     GTSQKRKSNP VPRGVAKIGD PLNFLFEWDG MVGPLPELAE CTNGVGVINT APEIDGVTRR
     VPLLMKIGDE VYPNMAIEVI RVAVGDPSYQ VKADMNGVVA MRVPGYDTIN TDTNGRIWVR
     WNKDFRVVSA GNDEDFQKAA GTTVIIAMTA EGLGGVIATP IGEQYDYVVS ANTLQTILDG
     ETIQRADWLI ELAVAFFLGC VIVLVCRFLP YWAIAIALVA ITFSAGYYIT FTFKSQLLFD
     ISWILVTAFV VAFHSTFLRF ILEFRAKQQI RKQFEKYLDP RQVAILVKDP SKLKLGGERK
     EMSFLFMDIV GFTPISEYYK NKDDPEGLVE VINDYLNRMS NIVLKNGGTI DKYMGDCIMA
     FWNAPLDCPN HAEMAVRTSI ECAEETDKIK EEFKQKGLPD INIGSGVNTG TCIVGNMGSE
     ARLDYSVIGD AVNLAARLEA QTRNYKDEKG KVTPTLYSSY TKEQLTNIKS VEVDKIKVKG
     KEELITIFKP Q
//