ID M1MIR6_9CLOT Unreviewed; 633 AA.
AC M1MIR6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Oligoendopeptidase F {ECO:0000256|RuleBase:RU368091};
DE EC=3.4.24.- {ECO:0000256|RuleBase:RU368091};
GN Name=yjbG {ECO:0000313|EMBL:AGF56218.1};
GN ORFNames=Cspa_c24530 {ECO:0000313|EMBL:AGF56218.1};
OS Clostridium saccharoperbutylacetonicum N1-4(HMT).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=931276 {ECO:0000313|EMBL:AGF56218.1, ECO:0000313|Proteomes:UP000011728};
RN [1] {ECO:0000313|EMBL:AGF56218.1, ECO:0000313|Proteomes:UP000011728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N1-4(HMT) {ECO:0000313|Proteomes:UP000011728};
RA Poehlein A., Daniel R.;
RT "Genome sequence of Clostridium saccharoperbutylacetonicum N1-4(HMT).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has oligopeptidase activity and degrades a variety of small
CC bioactive peptides. {ECO:0000256|RuleBase:RU368091}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU368091};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU368091};
CC -!- SIMILARITY: Belongs to the peptidase M3B family.
CC {ECO:0000256|RuleBase:RU368091}.
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DR EMBL; CP004121; AGF56218.1; -; Genomic_DNA.
DR RefSeq; WP_015392537.1; NZ_AOIF01000105.1.
DR AlphaFoldDB; M1MIR6; -.
DR STRING; 36745.CLSAP_22680; -.
DR KEGG; csr:Cspa_c24530; -.
DR PATRIC; fig|931276.5.peg.2458; -.
DR eggNOG; COG1164; Bacteria.
DR HOGENOM; CLU_021290_2_0_9; -.
DR OrthoDB; 9766487at2; -.
DR Proteomes; UP000011728; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09608; M3B_PepF; 1.
DR Gene3D; 1.10.1370.20; Oligoendopeptidase f, C-terminal domain; 1.
DR Gene3D; 1.20.140.70; Oligopeptidase f, N-terminal domain; 1.
DR Gene3D; 1.10.287.830; putative peptidase helix hairpin domain like; 1.
DR InterPro; IPR013647; OligopepF_N_dom.
DR InterPro; IPR042088; OligoPept_F_C.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR InterPro; IPR004438; Peptidase_M3B.
DR NCBIfam; TIGR00181; pepF; 1.
DR PANTHER; PTHR11804:SF79; MITOCHONDRIAL INTERMEDIATE PEPTIDASE; 1.
DR PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR Pfam; PF08439; Peptidase_M3_N; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU368091};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU368091};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU368091};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU368091};
KW Reference proteome {ECO:0000313|Proteomes:UP000011728};
KW Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU368091}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..633
FT /note="Oligoendopeptidase F"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004015582"
FT DOMAIN 140..203
FT /note="Oligopeptidase F N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08439"
FT DOMAIN 230..610
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 633 AA; 72350 MW; 6E21B04A1532B31F CRC64;
MKKNLQRKLV CVPLALSILL SQSAVFAAGP VTRDSVDQKY KWSIDDIYPT KDLFDADYKK
VTETYIPKLN SFKGHLTSAQ SIKDCLNTKD EMMRIVEKLY VYASMKSNED ESNSPNSEKK
SLTESLNSQV GVATAFIQTE ILAQSEDTIK KYMQDPLLAD YKHYIDRLLK EKAHTLSQGE
EEILAAASDM ASSPDDIYSK LKTDMEGFLP TIKDPENKDF KITNSSYGSM LDNQNRDFRK
KGFEELYSVY DKEKNSLAAT LNAEVKKNEF FAKERKYNSA EEAALADENI PVAVYDNLVS
SVDKNVNSLH KYVTLRKKIL GVDKVHLYDM YVPLTKNFDV KIPYEDGKKL VLKGLAPLGQ
DYIDVLSNAF ESRWADVYET NNKYSGAYQW GTYDTHPYVL MNYDESADSV LTTAHEFGHA
MNAYYTNKTQ KYVNSEQPIF TAEVASTANE LMMLRYLINN AKTDDEKLYY INTLAEDIRG
TVYTQTMYAE FEKMIHERVE KGEGISADSL SSMWKDLMVK YYGDDFQDDE LANLWWARIP
HFYMNFYVYK YATSMAASNQ LVKNMTEGTD ASKAEGVKKY RNFLTSGSSD YPIETLKKAG
VDVTTSESVD NLLKEFDQLV DQMDQILSKQ QKK
//
