ID M1PUG3_DESSD Unreviewed; 864 AA.
AC M1PUG3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=UWK_03444 {ECO:0000313|EMBL:AGF79961.1};
OS Desulfocapsa sulfexigens (strain DSM 10523 / SB164P1).
OC Bacteria; Thermodesulfobacteriota; Desulfobulbia; Desulfobulbales;
OC Desulfocapsaceae; Desulfocapsa.
OX NCBI_TaxID=1167006 {ECO:0000313|EMBL:AGF79961.1, ECO:0000313|Proteomes:UP000011721};
RN [1] {ECO:0000313|Proteomes:UP000011721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10523 / SB164P1 {ECO:0000313|Proteomes:UP000011721};
RX PubMed=23961312; DOI=10.4056/sigs.3777412;
RA Finster K.W., Kjeldsen K.U., Kube M., Reinhardt R., Mussmann M., Amann R.,
RA Schreiber L.;
RT "Complete genome sequence of Desulfocapsa sulfexigens, a marine
RT deltaproteobacterium specialized in disproportionating inorganic sulfur
RT compounds.";
RL Stand. Genomic Sci. 8:58-68(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP003985; AGF79961.1; -; Genomic_DNA.
DR RefSeq; WP_015405643.1; NC_020304.1.
DR AlphaFoldDB; M1PUG3; -.
DR STRING; 1167006.UWK_03444; -.
DR KEGG; dsf:UWK_03444; -.
DR eggNOG; COG2197; Bacteria.
DR eggNOG; COG3852; Bacteria.
DR HOGENOM; CLU_000445_114_77_7; -.
DR OrthoDB; 45683at2; -.
DR Proteomes; UP000011721; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00156; REC; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR029150; dCache_3.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR029151; Sensor-like_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR Pfam; PF14827; dCache_3; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000313|EMBL:AGF79961.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000011721};
KW Transferase {ECO:0000313|EMBL:AGF79961.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 496..722
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 743..858
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 792
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 864 AA; 97268 MW; D98825BCE17249A0 CRC64;
MTVNSNQDST KSSPSLSRPL LYRLMIPLST TILLLVLAFT TAFLMVHQQD MQRFNQHIMT
DAGRSLKISL IRNAQMLNSM EDIFLKDRYL YEALQAQDRE RLRTLYGPIF EKLHEKYSIT
HFYFHLPNRT NLLRLHKPNM HGDLIDRFTA RESARSGKTA SGIELGPLGT FTLRVVQPIY
VAETLIGYIE LGQEIETLLQ AIHRRLGVEM AVTIHKDALD QKQWEAGMNM LGREANWNRY
REEVLIYHSL PHFSSELDQF VHGNKDHRHN EITKKILFDN KSWQVLSHSL QDASGTDVGD
LIVFRDITDS QEAFVQLAAI TAAMALILLS GLFTFFYVML RRSDNSIQAQ HAKLVESEGR
HRSLLDAINR SGIFLFVVDG DYRVRYMNES MRETFGQASG KLCYHDVAGY ETPCSHCRLE
EVIGSQKTVY YHSTLANGRT FNMIAVPYVD TDGTACKLEV MQDITRQRQV EDEKEMLEQK
LQRAQKMEAI GLLAGGVAHD LNNILSGIVA YPELLLLKLP EDSELRKPIA AIQESGKRAA
AVVDDLLTVA RGVARVKESC NLNLLIQEYL DSPEYKALRS LHPHVTYRHQ LEASHPVLTC
SPVHIKKSLM NLVINATEAV TDEGSIIIST SNHYIDDAAA DAQNMRAGEY LILGVQDSGS
GIPDKDLIHI FEPFYTKKVM GRSGTGLGLA VVWNTVEEHQ GKIFVESGEN GTLFQLYFPV
SKKGEITQTM DAQAEILTGN GEHVLVVDDE PHLRDIASQM LHSLGYNVAS VCSGELAVQF
VKEKPVDLLV IDMLMEPGMN GRQTYEAILK LYPDQKAIVV SGFSESDDVK TTLQLGANGF
IKKPYTLEDL GRVVRRAFNC YNTD
//
