ID M1V9J9_CYAM1 Unreviewed; 1142 AA.
AC M1V9J9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Insulysin {ECO:0000313|EMBL:BAM81569.1};
GN ORFNames=CYME_CMO219C {ECO:0000313|EMBL:BAM81569.1};
OS Cyanidioschyzon merolae (strain NIES-3377 / 10D) (Unicellular red alga).
OC Eukaryota; Rhodophyta; Bangiophyceae; Cyanidiales; Cyanidiaceae;
OC Cyanidioschyzon.
OX NCBI_TaxID=280699 {ECO:0000313|EMBL:BAM81569.1, ECO:0000313|Proteomes:UP000007014};
RN [1] {ECO:0000313|EMBL:BAM81569.1, ECO:0000313|Proteomes:UP000007014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10D {ECO:0000313|EMBL:BAM81569.1,
RC ECO:0000313|Proteomes:UP000007014};
RX PubMed=15071595; DOI=10.1038/nature02398;
RA Matsuzaki M., Misumi O., Shin-i T., Maruyama S., Takahara M.,
RA Miyagishima S., Mori T., Nishida K., Yagisawa F., Nishida K., Yoshida Y.,
RA Nishimura Y., Nakao S., Kobayashi T., Momoyama Y., Higashiyama T.,
RA Minoda A., Sano M., Nomoto H., Oishi K., Hayashi H., Ohta F., Nishizaka S.,
RA Haga S., Miura S., Morishita T., Kabeya Y., Terasawa K., Suzuki Y.,
RA Ishii Y., Asakawa S., Takano H., Ohta N., Kuroiwa H., Tanaka K.,
RA Shimizu N., Sugano S., Sato N., Nozaki H., Ogasawara N., Kohara Y.,
RA Kuroiwa T.;
RT "Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon
RT merolae 10D.";
RL Nature 428:653-657(2004).
RN [2] {ECO:0000313|EMBL:BAM81569.1, ECO:0000313|Proteomes:UP000007014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10D {ECO:0000313|EMBL:BAM81569.1,
RC ECO:0000313|Proteomes:UP000007014};
RX PubMed=17623057; DOI=10.1186/1741-7007-5-28;
RA Nozaki H., Takano H., Misumi O., Terasawa K., Matsuzaki M., Maruyama S.,
RA Nishida K., Yagisawa F., Yoshida Y., Fujiwara T., Takio S., Tamura K.,
RA Chung S.J., Nakamura S., Kuroiwa H., Tanaka K., Sato N., Kuroiwa T.;
RT "A 100%-complete sequence reveals unusually simple genomic features in the
RT hot-spring red alga Cyanidioschyzon merolae.";
RL BMC Biol. 5:28-28(2007).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR EMBL; AP006497; BAM81569.1; -; Genomic_DNA.
DR RefSeq; XP_005537605.1; XM_005537548.1.
DR AlphaFoldDB; M1V9J9; -.
DR STRING; 280699.M1V9J9; -.
DR MEROPS; M16.008; -.
DR EnsemblPlants; CMO219CT; CMO219CT; CMO219C.
DR GeneID; 16995698; -.
DR Gramene; CMO219CT; CMO219CT; CMO219C.
DR KEGG; cme:CYME_CMO219C; -.
DR eggNOG; KOG0959; Eukaryota.
DR HOGENOM; CLU_004639_1_1_1; -.
DR OMA; WIFDEMK; -.
DR OrthoDB; 129328at2759; -.
DR Proteomes; UP000007014; Chromosome 15.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000007014};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 59..195
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 247..418
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 447..754
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 807..954
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1114..1142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1142 AA; 128238 MW; 5FB77A298F46D9CD CRC64;
MSDPTSNPAV QPAPQRSIEP CRTATEPPEG VTVFKWPRKP DIDERSYCYF RLASNNLQVL
LIQDPKANRA AASMSVGVGH MQDPPSYPGL AHFCEHMCFL GSDKYPDEGA YHEHIARHGG
HANAFTSLEE TNYAFEIGPE QLLETLDRFA QCFLHPRFHK AAVGREVDAV DAEYRMNIQS
DTHRLFQLLK SLTDPVHPFH NFGTGNRETL LGSASAAAAA AAEAAAEPHQ APTCLPAAVV
ESQESVREAL CEFHRQYYGA DLMCLCVSFT AHQTMAEMQS AVWSLFGEVP RALQKAPAAS
YAHQPLFRED HQPQGKLYVV EPVKALREMR IVFTIPPQRP LYRTKPAHCL AHLLGHESNG
SLLAALKEHG FATALSAGVS WELTGIAFFD IDIALTERGL VHWQQTLSLV GAYLRLLRTL
LGPGDILDAD LPSYIYEELQ LLGEIHFRYQ ERESSPFQAV VELSSSLRVF DPEDVLAGPF
LYWDRPSACA LRELLSEHMC PEQAIVFLVT TEMYQQPEAY GLESTQLVHG LEPWYQTRYL
TGTMPAAAWY SETPAARALH VPLPNPFMPR SFSLKVAPAA GTAAADANGQ QPLPRCLLLD
EAQGRVLHHS LDTSFRQPRI QAFFQLYTDM AYASPEQAIF TKLAIALIED ALTASAYDAE
LAGMSYTLTP TATGVFLGLS GFADTFIRFT EHVFRTAAAT CSGEDVKQST EIRQRLLDAH
LDRLRRSYED AALQKPYQQV MYNTRVLLQL PHWHATWDYL SLLREASSAG TERFSLESVD
AFRTTLFGGA SGAPGCSMRN LVVEALLHGN VTEDEARLLF DRCMAIVQPC LRPEVGDLRQ
FLRRLECHQL RIPAELSPLG LFIPLPNATE SNASLGYYVQ TGVRSLERDL LVEVLSNLLQ
KPLFHELRTV QQLGYVVSNF VYRRCGAQGL FFLVQSTERH PPWHVAERLE CFLHDFYQNQ
LQRLRVDDLR PYLEAMAEKR EEPDRNLPER GARFWAEIEH GTYQYQRGEQ EARYLRALLK
QDTDEAATDV NATGTLSLVK FHALLRTFWE NEVCGHRHGG SLRVYAVPFC WMPVEGGALQ
VDQVAAYLAT KETQQGLEER TRTLLLATAA SVRKWQQHAS RYPSEREYES PPTSLEPHGE
NP
//
