ID M1VCW2_CYAM1 Unreviewed; 1451 AA.
AC M1VCW2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Bacterial DNA polymerase I {ECO:0000313|EMBL:BAM83394.1};
GN ORFNames=CYME_CMT462C {ECO:0000313|EMBL:BAM83394.1};
OS Cyanidioschyzon merolae (strain NIES-3377 / 10D) (Unicellular red alga).
OC Eukaryota; Rhodophyta; Bangiophyceae; Cyanidiales; Cyanidiaceae;
OC Cyanidioschyzon.
OX NCBI_TaxID=280699 {ECO:0000313|EMBL:BAM83394.1, ECO:0000313|Proteomes:UP000007014};
RN [1] {ECO:0000313|EMBL:BAM83394.1, ECO:0000313|Proteomes:UP000007014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10D {ECO:0000313|EMBL:BAM83394.1,
RC ECO:0000313|Proteomes:UP000007014};
RX PubMed=15071595; DOI=10.1038/nature02398;
RA Matsuzaki M., Misumi O., Shin-i T., Maruyama S., Takahara M.,
RA Miyagishima S., Mori T., Nishida K., Yagisawa F., Nishida K., Yoshida Y.,
RA Nishimura Y., Nakao S., Kobayashi T., Momoyama Y., Higashiyama T.,
RA Minoda A., Sano M., Nomoto H., Oishi K., Hayashi H., Ohta F., Nishizaka S.,
RA Haga S., Miura S., Morishita T., Kabeya Y., Terasawa K., Suzuki Y.,
RA Ishii Y., Asakawa S., Takano H., Ohta N., Kuroiwa H., Tanaka K.,
RA Shimizu N., Sugano S., Sato N., Nozaki H., Ogasawara N., Kohara Y.,
RA Kuroiwa T.;
RT "Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon
RT merolae 10D.";
RL Nature 428:653-657(2004).
RN [2] {ECO:0000313|EMBL:BAM83394.1, ECO:0000313|Proteomes:UP000007014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10D {ECO:0000313|EMBL:BAM83394.1,
RC ECO:0000313|Proteomes:UP000007014};
RX PubMed=17623057; DOI=10.1186/1741-7007-5-28;
RA Nozaki H., Takano H., Misumi O., Terasawa K., Matsuzaki M., Maruyama S.,
RA Nishida K., Yagisawa F., Yoshida Y., Fujiwara T., Takio S., Tamura K.,
RA Chung S.J., Nakamura S., Kuroiwa H., Tanaka K., Sato N., Kuroiwa T.;
RT "A 100%-complete sequence reveals unusually simple genomic features in the
RT hot-spring red alga Cyanidioschyzon merolae.";
RL BMC Biol. 5:28-28(2007).
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DR EMBL; AP006502; BAM83394.1; -; Genomic_DNA.
DR RefSeq; XP_005539430.1; XM_005539373.1.
DR STRING; 280699.M1VCW2; -.
DR EnsemblPlants; CMT462CT; CMT462CT; CMT462C.
DR GeneID; 16997666; -.
DR Gramene; CMT462CT; CMT462CT; CMT462C.
DR KEGG; cme:CYME_CMT462C; -.
DR eggNOG; KOG0950; Eukaryota.
DR HOGENOM; CLU_004675_0_0_1; -.
DR OMA; NRPPMPD; -.
DR OrthoDB; 208079at2759; -.
DR Proteomes; UP000007014; Chromosome 20.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:UniProt.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd09898; H3TH_53EXO; 1.
DR CDD; cd09859; PIN_53EXO; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR InterPro; IPR002421; 5-3_exonuclease.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR020045; DNA_polI_H3TH.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF01367; 5_3_exonuc; 1.
DR Pfam; PF02739; 5_3_exonuc_N; 1.
DR Pfam; PF00476; DNA_pol_A; 2.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00475; 53EXOc; 1.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000007014};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 295..565
FT /note="5'-3' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00475"
FT DOMAIN 1191..1411
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 668..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1015..1042
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 674..689
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1451 AA; 159276 MW; ABBDC6D1591BC77D CRC64;
MFAVCWYSLP RPPLTNGPPE RVPVSAWQNA RLTRTRSGRR VWFSVSTGCN DTRYTNLCEW
MGSEALAAKI YAKQRKLVEA RLKSAAFCSF GRQNRSSFRL WLLLPTRPRI SCGSERVREL
CLVSSFSFRL CCCFMASVRS SHGCCERSRK VPLTWGTPWA GRLLLSLAVL RTASRARRCV
RGPELSVVRL LLSTTSKQRG RVRQSGARWR STSCGGSQSG FCSLADVKTR PSPPAVRCLA
QGPEAASASA QWSVPANSRT GPWTQTTGIE HANKNASPAH EAGVMASDAQ DQWLPTLFLV
DALSIVYRSY YAFQKNPLYS SSGINTSAIY GFIQTILLLL QKYNPEALAV VFDSHTTEPG
PGSFRQLLFP KYKANRERMP DGVRDALPYV KRAIHQLGLQ SFELESFEAD DVIGTLAALA
NHNGYRVVIV SNDKDFKQLI KAGWVRLLRP TRSSGSGGFD EVTEADLAAE CGTSIRPQQY
PDVLALAGDA VDNIPGVPGI GIKTAARLIR QFSSIEDLIC NLDAIEPPRI QEKIISKADE
LLRNKVLAKI HQNVPLEKLQ SERSPSADAG NELVTDAPAY DAMWIASCRR GPWQLNALLT
LLRELDMEAL SRRIQYLARS LGQSDHEKRT SASARDSLET GFMAAPRERL DSPLANDEVI
NQPLASEQEI PPDSQHNNLH DHVDDRLQPA AGPARDVPFT SVTDDSATAV PGSAQESTRS
TSAQSAELRP NSASVPANWS ADELSMYLGA PLRYQIMEAD ALLHFLDGSG THEPIGLFMA
HVMPETRRRP RHRTKEAAAA PADAVNTVRL SPNSADATTT TTTTTTTNTH TTAATAAVAE
HPLILMGIAT DQGNAAGAVL PATAPWLDTW LRQLRERLDQ AHQRHVGFDL KHVLRFLLAR
DDVRADGVWI DPAVAHALLY PEEAFERPEL LAKRYLGDLG VALWNRYVEA PLTSASTSET
RTEALALAAA FQADLARHIF HRQVTRLDAV GMRALAFQVE FPLTLVLADM ERTGVYVAQQ
ELRELEEKME RELRDIETQI YALAGTTFNI RSADQLARVL FEQLGVDAPL RTPGGKASTA
DRVLAALVRR YGQEGERGTA ALVGASPREH GAEASAIDAS KASRAASIAA LTQEYRQIAK
LLSTYVRGLV GHIDPKTQRI HATFHQTGAI TGRLSSSAPN LQSIPIRSTR GRALRSLFRA
TPIDTVHRAG GTEPAGNVLI SADYEQIELR IIGALSGDAV LLQAFRDQVD VHATTARHLF
GLPFDAKVSA AQRTAAKAIN YGIPYGVTAY GLAQNLRISV AEARKLIREY HDAFPGVARL
KRELLDKARA TGYASTLLGR RRYLPALHSR NYAERTAAER AAVNMPIQGS QADMIKVAMV
RIWQALRSQH LRTRIVIQIH DELVFEAPES ELASVMPLIQ VQMERALILP NDVPVKVRIG
YGVSWAAAHA P
//
