ID M1VLS0_CYAM1 Unreviewed; 512 AA.
AC M1VLS0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=3-isopropylmalate dehydratase {ECO:0000313|EMBL:BAM82718.1};
GN ORFNames=CYME_CMS078C {ECO:0000313|EMBL:BAM82718.1};
OS Cyanidioschyzon merolae (strain NIES-3377 / 10D) (Unicellular red alga).
OC Eukaryota; Rhodophyta; Bangiophyceae; Cyanidiales; Cyanidiaceae;
OC Cyanidioschyzon.
OX NCBI_TaxID=280699 {ECO:0000313|EMBL:BAM82718.1, ECO:0000313|Proteomes:UP000007014};
RN [1] {ECO:0000313|EMBL:BAM82718.1, ECO:0000313|Proteomes:UP000007014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10D {ECO:0000313|EMBL:BAM82718.1,
RC ECO:0000313|Proteomes:UP000007014};
RX PubMed=15071595; DOI=10.1038/nature02398;
RA Matsuzaki M., Misumi O., Shin-i T., Maruyama S., Takahara M.,
RA Miyagishima S., Mori T., Nishida K., Yagisawa F., Nishida K., Yoshida Y.,
RA Nishimura Y., Nakao S., Kobayashi T., Momoyama Y., Higashiyama T.,
RA Minoda A., Sano M., Nomoto H., Oishi K., Hayashi H., Ohta F., Nishizaka S.,
RA Haga S., Miura S., Morishita T., Kabeya Y., Terasawa K., Suzuki Y.,
RA Ishii Y., Asakawa S., Takano H., Ohta N., Kuroiwa H., Tanaka K.,
RA Shimizu N., Sugano S., Sato N., Nozaki H., Ogasawara N., Kohara Y.,
RA Kuroiwa T.;
RT "Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon
RT merolae 10D.";
RL Nature 428:653-657(2004).
RN [2] {ECO:0000313|EMBL:BAM82718.1, ECO:0000313|Proteomes:UP000007014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10D {ECO:0000313|EMBL:BAM82718.1,
RC ECO:0000313|Proteomes:UP000007014};
RX PubMed=17623057; DOI=10.1186/1741-7007-5-28;
RA Nozaki H., Takano H., Misumi O., Terasawa K., Matsuzaki M., Maruyama S.,
RA Nishida K., Yagisawa F., Yoshida Y., Fujiwara T., Takio S., Tamura K.,
RA Chung S.J., Nakamura S., Kuroiwa H., Tanaka K., Sato N., Kuroiwa T.;
RT "A 100%-complete sequence reveals unusually simple genomic features in the
RT hot-spring red alga Cyanidioschyzon merolae.";
RL BMC Biol. 5:28-28(2007).
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DR EMBL; AP006501; BAM82718.1; -; Genomic_DNA.
DR RefSeq; XP_005538754.1; XM_005538697.1.
DR AlphaFoldDB; M1VLS0; -.
DR STRING; 280699.M1VLS0; -.
DR EnsemblPlants; CMS078CT; CMS078CT; CMS078C.
DR GeneID; 16997414; -.
DR Gramene; CMS078CT; CMS078CT; CMS078C.
DR KEGG; cme:CYME_CMS078C; -.
DR eggNOG; KOG0454; Eukaryota.
DR HOGENOM; CLU_006714_3_4_1; -.
DR OMA; LCDADNI; -.
DR OrthoDB; 1122834at2759; -.
DR UniPathway; UPA00048; UER00071.
DR Proteomes; UP000007014; Chromosome 19.
DR GO; GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0050486; F:intramolecular hydroxytransferase activity; IEA:EnsemblPlants.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019761; P:glucosinolate biosynthetic process; IEA:EnsemblPlants.
DR GO; GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01583; IPMI; 1.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR006251; Homoacnase/IPMdehydase_lsu.
DR InterPro; IPR033941; IPMI_cat.
DR NCBIfam; TIGR01343; hacA_fam; 1.
DR PANTHER; PTHR43822:SF2; 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT, CHLOROPLASTIC; 1.
DR PANTHER; PTHR43822; HOMOACONITASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF00330; Aconitase; 2.
DR PRINTS; PR00415; ACONITASE.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007014}.
FT DOMAIN 78..350
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
FT DOMAIN 355..488
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
SQ SEQUENCE 512 AA; 55711 MW; 5BFBB9778B50E5B0 CRC64;
MFVSPVTLHS RAQGCSARTG VSQEQRRVRI GPKNPLAELK SGISAPTSTK AAPSVAVKAP
QTITEKIIAK AAGRSFVKPG ENLFVDVDVL MTHDVCGPGT IAVFKREFGS DAPVWDPEKI
VIIPDHYIFT ADEKANRNVD IIRDFAREQG IRYFYDITDR SDFRANPEYK GVCHIALAQE
GHCRPGEVLF GTDSHTCTAG AFGEFATGIG NTDAGFIMGT GKLLIKVPAT MRFALNGTLP
DYIMAKDIIL QIIGDIGVAG ATYRAMEFVS DRMEQFSIAD RMTLCNMAIE AGGKNGIFPP
DEITCAYVRA RTTKPFDVFH TDSNASFYTD RQYDLSKLEP AVAKPHSPDN LDLARNCEDV
KITRVYIGSC TGGKTEDFVA AARILDGRQV RVPTFLVPAT RRIYEDLETR KLNGKTLMQI
FKDAGCLPPG APSCAACLGG PKDTFGRANG PEVVVSTTNR NFPGRMGDKS SAVFLASPYT
AAASAITGHI TDPRRVYDFD RVRHPLETYG LS
//
