ID M1VV74_CLAP2 Unreviewed; 455 AA.
AC M1VV74;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Related to pentafunctional arom polypeptide {ECO:0000313|EMBL:CCE29027.1};
GN ORFNames=CPUR_02718 {ECO:0000313|EMBL:CCE29027.1};
OS Claviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Claviceps.
OX NCBI_TaxID=1111077 {ECO:0000313|EMBL:CCE29027.1, ECO:0000313|Proteomes:UP000016801};
RN [1] {ECO:0000313|EMBL:CCE29027.1, ECO:0000313|Proteomes:UP000016801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=20.1 {ECO:0000313|EMBL:CCE29027.1,
RC ECO:0000313|Proteomes:UP000016801};
RX PubMed=23468653; DOI=10.1371/journal.pgen.1003323;
RA Schardl C.L., Young C.A., Hesse U., Amyotte S.G., Andreeva K., Calie P.J.,
RA Fleetwood D.J., Haws D.C., Moore N., Oeser B., Panaccione D.G.,
RA Schweri K.K., Voisey C.R., Farman M.L., Jaromczyk J.W., Roe B.A.,
RA O'Sullivan D.M., Scott B., Tudzynski P., An Z., Arnaoudova E.G.,
RA Bullock C.T., Charlton N.D., Chen L., Cox M., Dinkins R.D., Florea S.,
RA Glenn A.E., Gordon A., Gueldener U., Harris D.R., Hollin W., Jaromczyk J.,
RA Johnson R.D., Khan A.K., Leistner E., Leuchtmann A., Li C., Liu J., Liu J.,
RA Liu M., Mace W., Machado C., Nagabhyru P., Pan J., Schmid J., Sugawara K.,
RA Steiner U., Takach J.E., Tanaka E., Webb J.S., Wilson E.V., Wiseman J.L.,
RA Yoshida R., Zeng Z.;
RT "Plant-symbiotic fungi as chemical engineers: Multi-genome analysis of the
RT Clavicipitaceae reveals dynamics of alkaloid loci.";
RL PLoS Genet. 9:E1003323-E1003323(2013).
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCE29027.1}.
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DR EMBL; CAGA01000011; CCE29027.1; -; Genomic_DNA.
DR AlphaFoldDB; M1VV74; -.
DR STRING; 1111077.M1VV74; -.
DR VEuPathDB; FungiDB:CPUR_02718; -.
DR eggNOG; KOG0692; Eukaryota.
DR HOGENOM; CLU_001201_0_4_1; -.
DR OrthoDB; 453at2759; -.
DR Proteomes; UP000016801; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:InterPro.
DR CDD; cd08199; EEVS; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR030960; DHQS/DOIS.
DR InterPro; IPR035872; EEVS-like.
DR PANTHER; PTHR43622; 3-DEHYDROQUINATE SYNTHASE; 1.
DR PANTHER; PTHR43622:SF1; 3-DEHYDROQUINATE SYNTHASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01761; DHQ_synthase; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
PE 4: Predicted;
KW Lyase {ECO:0000256|ARBA:ARBA00023239}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000016801}.
FT DOMAIN 86..335
FT /note="3-dehydroquinate synthase"
FT /evidence="ECO:0000259|Pfam:PF01761"
FT REGION 410..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 455 AA; 50541 MW; 89F46E5E5A0DF2D4 CRC64;
MSDMKATVEP VSNGFAVTGY EKIEYGFEFL DGVFDVQNPQ LAKCYQKWQR CLAVMDYNIF
TLYGKAIQAY FDHHQIKLTI HKTMIGEKAK TMETLLSIVD SMNDFGVFRK EPVLVVGGGL
VTDVAGFACA SYRRNTNYIR IPTTVIGLID ASVSIKVAVN YGGCKNRLGA YHAPQHTFLD
FTFLRTLPVG QIRNGFAELI KISSCADKTT FDLLDKYCEQ MITTAFGRLE SSDEIKVAAD
KICKAGIYEM LKLETPNLHE IMLDRVIAYG HTWSPLHELV PNPPLRHGHA ISIDMAYSAT
LSRKRNLLTE EDHMRLLRLF SRAGLSMDHP QFDAPMLDKA TAAILRTRDG KLRLAVPISP
IGECVFLNDV SHEEMSEVLE VHKKLVGQFP REGKGLDAFV DASDTGYNVH DASAAGTSGA
EEKQAESNQT VPVSLRSQKP MDHQGRLGGD VAVRV
//
