ID M1VYP5_CLAP2 Unreviewed; 450 AA.
AC M1VYP5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=PLD phosphodiesterase domain-containing protein {ECO:0000259|PROSITE:PS50035};
GN ORFNames=CPUR_08184 {ECO:0000313|EMBL:CCE34252.1};
OS Claviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Claviceps.
OX NCBI_TaxID=1111077 {ECO:0000313|EMBL:CCE34252.1, ECO:0000313|Proteomes:UP000016801};
RN [1] {ECO:0000313|EMBL:CCE34252.1, ECO:0000313|Proteomes:UP000016801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=20.1 {ECO:0000313|EMBL:CCE34252.1,
RC ECO:0000313|Proteomes:UP000016801};
RX PubMed=23468653; DOI=10.1371/journal.pgen.1003323;
RA Schardl C.L., Young C.A., Hesse U., Amyotte S.G., Andreeva K., Calie P.J.,
RA Fleetwood D.J., Haws D.C., Moore N., Oeser B., Panaccione D.G.,
RA Schweri K.K., Voisey C.R., Farman M.L., Jaromczyk J.W., Roe B.A.,
RA O'Sullivan D.M., Scott B., Tudzynski P., An Z., Arnaoudova E.G.,
RA Bullock C.T., Charlton N.D., Chen L., Cox M., Dinkins R.D., Florea S.,
RA Glenn A.E., Gordon A., Gueldener U., Harris D.R., Hollin W., Jaromczyk J.,
RA Johnson R.D., Khan A.K., Leistner E., Leuchtmann A., Li C., Liu J., Liu J.,
RA Liu M., Mace W., Machado C., Nagabhyru P., Pan J., Schmid J., Sugawara K.,
RA Steiner U., Takach J.E., Tanaka E., Webb J.S., Wilson E.V., Wiseman J.L.,
RA Yoshida R., Zeng Z.;
RT "Plant-symbiotic fungi as chemical engineers: Multi-genome analysis of the
RT Clavicipitaceae reveals dynamics of alkaloid loci.";
RL PLoS Genet. 9:E1003323-E1003323(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCE34252.1}.
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DR EMBL; CAGA01000081; CCE34252.1; -; Genomic_DNA.
DR AlphaFoldDB; M1VYP5; -.
DR STRING; 1111077.M1VYP5; -.
DR VEuPathDB; FungiDB:CPUR_08184; -.
DR eggNOG; KOG2031; Eukaryota.
DR HOGENOM; CLU_007773_2_0_1; -.
DR OrthoDB; 930461at2759; -.
DR Proteomes; UP000016801; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd09122; PLDc_Tdp1_1; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR InterPro; IPR010347; Tdp1.
DR InterPro; IPR003903; UIM_dom.
DR PANTHER; PTHR12415; TYROSYL-DNA PHOSPHODIESTERASE 1; 1.
DR PANTHER; PTHR12415:SF4; TYROSYL-DNA PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF06087; Tyr-DNA_phospho; 1.
DR Pfam; PF02809; UIM; 1.
DR SMART; SM00726; UIM; 1.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 1.
DR PROSITE; PS50330; UIM; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000016801}.
FT DOMAIN 410..449
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT REGION 60..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 195
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-1"
FT ACT_SITE 415
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-1"
FT BINDING 197
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-2"
FT BINDING 417
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-2"
FT SITE 446
FT /note="Interaction with DNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-3"
SQ SEQUENCE 450 AA; 50184 MW; FB9D4AAC08E537DC CRC64;
MGSHDESEDE QLKYAIALSL QQAGPEEQDV IPEPIRPRSR DPSFGLLLLN RKQMEEERLA
RLAAKRSRST SQGDDIGDMP ATKRGRKSPA NRLIDKVSIP FPDGVVKRTW AKGYDRTDDD
IHIDEVLQTD QLLLAMFSSF QWNEPWLLSK IDLSRTKVLL AAYAADDAQK EMMRSNAPQN
IKFCFPRMQG FGNMHSKLQI LKFSHYLRIV VPTGNLVPHD WGETGIMENM VFLIDLPLLN
DDNRSRQMTL FQTHLQHYLQ AMGIEAGMIA SLSKPGEHSG GPKPRVGFAG LGTTIADLGL
ATSEPIEVDY ACASLGAIKY GFVKSMYSAC RGSVDKALLG IDENPYSGGN DADEALQSRQ
NFRIYFPSHN TIVSSRGGKI SAGTICFQES WWRSSTFPKE MMRDCINTRK GLLMHSKVIL
VRHAGCTAHD AEKRAAWAYI GSANLSESAW
//
