ID M1W2C7_CLAP2 Unreviewed; 2676 AA.
AC M1W2C7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Probable translation activator GCN1 {ECO:0000313|EMBL:CCE31751.1};
GN ORFNames=CPUR_05606 {ECO:0000313|EMBL:CCE31751.1};
OS Claviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Claviceps.
OX NCBI_TaxID=1111077 {ECO:0000313|EMBL:CCE31751.1, ECO:0000313|Proteomes:UP000016801};
RN [1] {ECO:0000313|EMBL:CCE31751.1, ECO:0000313|Proteomes:UP000016801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=20.1 {ECO:0000313|EMBL:CCE31751.1,
RC ECO:0000313|Proteomes:UP000016801};
RX PubMed=23468653; DOI=10.1371/journal.pgen.1003323;
RA Schardl C.L., Young C.A., Hesse U., Amyotte S.G., Andreeva K., Calie P.J.,
RA Fleetwood D.J., Haws D.C., Moore N., Oeser B., Panaccione D.G.,
RA Schweri K.K., Voisey C.R., Farman M.L., Jaromczyk J.W., Roe B.A.,
RA O'Sullivan D.M., Scott B., Tudzynski P., An Z., Arnaoudova E.G.,
RA Bullock C.T., Charlton N.D., Chen L., Cox M., Dinkins R.D., Florea S.,
RA Glenn A.E., Gordon A., Gueldener U., Harris D.R., Hollin W., Jaromczyk J.,
RA Johnson R.D., Khan A.K., Leistner E., Leuchtmann A., Li C., Liu J., Liu J.,
RA Liu M., Mace W., Machado C., Nagabhyru P., Pan J., Schmid J., Sugawara K.,
RA Steiner U., Takach J.E., Tanaka E., Webb J.S., Wilson E.V., Wiseman J.L.,
RA Yoshida R., Zeng Z.;
RT "Plant-symbiotic fungi as chemical engineers: Multi-genome analysis of the
RT Clavicipitaceae reveals dynamics of alkaloid loci.";
RL PLoS Genet. 9:E1003323-E1003323(2013).
CC -!- SIMILARITY: Belongs to the GCN1 family.
CC {ECO:0000256|ARBA:ARBA00007366}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCE31751.1}.
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DR EMBL; CAGA01000034; CCE31751.1; -; Genomic_DNA.
DR STRING; 1111077.M1W2C7; -.
DR VEuPathDB; FungiDB:CPUR_05606; -.
DR eggNOG; KOG1242; Eukaryota.
DR HOGENOM; CLU_000504_2_0_1; -.
DR OrthoDB; 6844at2759; -.
DR Proteomes; UP000016801; Unassembled WGS sequence.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 6.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR022716; Gcn1_N.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR23346:SF7; EIF-2-ALPHA KINASE ACTIVATOR GCN1; 1.
DR PANTHER; PTHR23346; TRANSLATIONAL ACTIVATOR GCN1-RELATED; 1.
DR Pfam; PF12074; Gcn1_N; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR SMART; SM01349; TOG; 2.
DR SUPFAM; SSF48371; ARM repeat; 4.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000016801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1343..1579
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 1520..1558
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 1663..1919
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 1983..2020
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REGION 2636..2658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2676 AA; 289782 MW; D722191DFE7413FA CRC64;
MSEEMAGANG PEAASTGLDV AATGRALRLS STSARIAQLH HVDEAVRRKD VDESTTVGIL
KLLFATHAFY RDRNSRLAVQ QCITSIIKAG ASTQALLPFA RAVRLETQKP GIAKSNAFVL
SEWCSLLMQH VNNDVWEQLG NEVLLASADA VEKSLQSGAR SGLARSAIGV TRRGFRKLLA
SPDTREQRLS TAVTTLTAKG NQPTAKNAVI LGIIAGVSAR QAPLKPLLEA LKPKFYEFYS
REIVGSRNAL PEHVSSGLAD FFSSFATIDD VETSLVPAIE KGLLRAPELV LAGVLKPFVS
SLPVDFDLSG TLQSKLLKPL LLNIKSSNPT IRSGAISAFR AIVAKCNNLQ LLENVVDEIA
TPLAAGKLPA AEQKILHSEM LQCTPLSTQS ATKILTSVST VATKEGNEAA LAAETSALAH
AIIMTLKEGG DLPKPVVDAV TKGLADKKPA SRRLWLLRTG AILQACEAVA ATSGLTAFAD
AVTPKLIANL QEVISNAATA AQNGLVVGAY VLTALSPAMT RQFPDSATSA ALSKASISSH
ALSLVAKQSF LLNYRVYSKV TSEEDLRWLS RALASAAQNL NHNSNADVAL AWAEAYIYLM
AAASVAPKMQ QEAVHTVSSL YVKQPEFISK MIINGLWNQF NSNDAKENDV KVAESNLINV
LRSVCLDPQE VSSLGGSISS DALESQACSI LVLSRPELIP RSSWIDMCLR MAVDPGALVK
KHLDALLQEI DSKTSIDQKV DKIQQAAHNS AAELAFVAPE VAIPRLIELI GGDLDPEQLR
NIGPMEAAIY RTPEGTCFVD VLAKKGQNSA PNKNNKDYDI LKWEEELRSQ LEKKKGQQRK
LTAEETSKVN AQLKKESGVR SSIRKIEAKL LRGIGIIKSL ATGPPTDATL WLGSAVGLIL
AVIDAGAGLI VGDIAPQAFT LCSEKVSARL GPIRQFIGVA TLRLRSITLA ENLDEEKLED
LITRVLYRLR FAGEQRPFDA VSLIYIMPLL LDVLRKGGVG ENSDDKDEQL VLAVEFLSFH
TDVCADEAVP REELLTILIQ SLQQYTQHYK LIKDCFADIC RCIAPNMTQA EMRLLAKGAI
VAQSSVRSSV LQSISSEVDM TELGYSDEIW LACHDDEQEN RELGAEIWEE SAFTVGSDVP
MRMLPYLESK DAQLRRAAAR SLAEAVQKHI GALDEVIPKL QSMYAELAKP KVQQLDEYGM
PKKMDLSDPW EARQGIASAF KELAPVLNSQ QIDELFNFLI ESGPLGDRSD NVRREMLDAA
VAATETHGKD MIDALMDKFE KTLEQPDKNS TAADRVNEAV IIMYGALARH LAPGDSKIPV
VIERLLLTLN TPSETVQFAI AECLPPLVRA CSDKSSKYFD QVLAELLNSK NYASQRGAAY
GLAGLVLGRG IASLREYRIL STLKSAMDNK KEAHQREAAL LAFELLSTVL GRLFEPYVLQ
IVPQLLNGFG DSNGDVRDAC LAAAKACFGQ LSSYGVKQIM PTLLNGLDDQ QWRSKRGACD
LLGAMAYLDP NQLADSLPDI IPPLTGVLND SHKEVRAAAN RSLKRFGEVI NNPEIKGLVD
VLLKALSDPT RYTDEALDSL IKVQFVHYLD APSLALVTRI LQRGLDDRSN TKRKAAQVIG
SLAHLTEKKD IITHLPILIA GLKLAAVDPV PTTRATASRA LGSLVEKLGE DAMPDLIPGL
MQTLKSDTGA GDRLGSAQAL SEVLAGLGTS RLEETLPTVL QNVESSKPAV REGFMSLFIF
LPVCFGNSFS NYLGRIVPPI LAGLADDMES IRETALRAGR LLVKNFAVRA VDLLLPELER
GLADDSYRIR LSSVELVGDL LFNLTGVKAN ADGEDEEADE EAVKEAGASL KEVLGEEKRN
KILSALYVCR CDTAGSVRSA AVAVWKVLVH SPRILKELVP TLTQLLVRRL GSSNMEHKVI
ASNALGELIR KAGDGVLSTL LPTLEEGLQT STDSDAKQGI CLALRELISS ASPEALEDHE
KLLISVVRTA LTDSDEEVRE AAAEAFDSLQ QILGKRAVDQ VLPFLLNLLR SEDTADNALS
ALLTLLTETT RSNIILPNLI PTLTKPPISA FDAKALASLS KVAGAAMNRR LPGIINSLMD
NEINCEDEDL QTDLESSFDT VIQSIDEYDG LNIVMNVLLG LLKHEDHRRR AATARHMRNF
FAASAVDYSR YNQDIVRSLL NSFDDHDVEV VKASWAALSE FTKKLKKEEM EGLVVSTRQT
LVRVGVAGAN LRGFELPKGI NAVLPIFLQG LMNGTVEQRI QSALGISDIV DRASEASLKP
FVTQITGPLI RVVSERTTEV KAAIMLTLNT LLDKMPIALK PFLPQLQRTF AKALADTSSD
VLRSRAAKAL GTLIKHTPRV DPLIAELVTG CKTTDAGVKT AMLKALYEVI SRAGANMGEI
SRTSVLSVID MDTDERDEAM TITNAKLLGA LIKNVPEEAA TSLLRNRVLT PQFSKSSVLA
LNAVLVESPD ALLQSAAAAE ELPDLLCQGI ADKSTFISEN FILATGKVLL SSPPKSFDSI
KKIFESLADI IPPGKPTDSR RLALVVVRTL SRANMELVRP HVPLLAGPVF ASVRDLVIPV
KLAAEAAFVE LFSVVDEENR VFDNFMAGAG ADLPANTKRS MMDYFKRVAT RLGAQARERR
EAEGGQGGLG LSDDEQDDEK EIWSVGKLEF ASEVFS
//
