ID M1W2Y5_CLAP2 Unreviewed; 1153 AA.
AC M1W2Y5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Related to cell division control protein 25 (GDP/GTP exchange factor) {ECO:0000313|EMBL:CCE32276.1};
GN ORFNames=CPUR_06136 {ECO:0000313|EMBL:CCE32276.1};
OS Claviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Claviceps.
OX NCBI_TaxID=1111077 {ECO:0000313|EMBL:CCE32276.1, ECO:0000313|Proteomes:UP000016801};
RN [1] {ECO:0000313|EMBL:CCE32276.1, ECO:0000313|Proteomes:UP000016801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=20.1 {ECO:0000313|EMBL:CCE32276.1,
RC ECO:0000313|Proteomes:UP000016801};
RX PubMed=23468653; DOI=10.1371/journal.pgen.1003323;
RA Schardl C.L., Young C.A., Hesse U., Amyotte S.G., Andreeva K., Calie P.J.,
RA Fleetwood D.J., Haws D.C., Moore N., Oeser B., Panaccione D.G.,
RA Schweri K.K., Voisey C.R., Farman M.L., Jaromczyk J.W., Roe B.A.,
RA O'Sullivan D.M., Scott B., Tudzynski P., An Z., Arnaoudova E.G.,
RA Bullock C.T., Charlton N.D., Chen L., Cox M., Dinkins R.D., Florea S.,
RA Glenn A.E., Gordon A., Gueldener U., Harris D.R., Hollin W., Jaromczyk J.,
RA Johnson R.D., Khan A.K., Leistner E., Leuchtmann A., Li C., Liu J., Liu J.,
RA Liu M., Mace W., Machado C., Nagabhyru P., Pan J., Schmid J., Sugawara K.,
RA Steiner U., Takach J.E., Tanaka E., Webb J.S., Wilson E.V., Wiseman J.L.,
RA Yoshida R., Zeng Z.;
RT "Plant-symbiotic fungi as chemical engineers: Multi-genome analysis of the
RT Clavicipitaceae reveals dynamics of alkaloid loci.";
RL PLoS Genet. 9:E1003323-E1003323(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCE32276.1}.
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DR EMBL; CAGA01000039; CCE32276.1; -; Genomic_DNA.
DR AlphaFoldDB; M1W2Y5; -.
DR STRING; 1111077.M1W2Y5; -.
DR VEuPathDB; FungiDB:CPUR_06136; -.
DR eggNOG; KOG2070; Eukaryota.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_002632_0_0_1; -.
DR OrthoDB; 68574at2759; -.
DR PhylomeDB; M1W2Y5; -.
DR Proteomes; UP000016801; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000313|EMBL:CCE32276.1};
KW Cell division {ECO:0000313|EMBL:CCE32276.1};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000016801};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 10..69
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 735..868
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 904..1141
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 104..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1153 AA; 129084 MW; 6EA5A74EF917F095 CRC64;
MDGIVGSAPP GSMFVRALYD YEADDRTSLS FHEGDIIQVI TQLESGWWDG MINGVRGWFP
SNYCQLISAP DDLPDLPSVQ SHNGFLDYIN DEVDTAVGFE KTFDQDDDSE ADGSGSHPPL
ESADASHQSR ADFWIPQATA DGRLFYYNMM TGDRSMELPL ESPVSSTETG PRDRANVNVP
DKTRPPPEMM ARGLTRDEDD SSITSASEAE GESLMRNYMR NRASISGMLS PSTSMDSISG
VSPVRHRRTE ALSTGVQATG QSPEMASATS FTSTTYNLPT TATVSRSFFN DGYTSPLTWS
LLVTNMKRAI DRYRDAIANG RRSEYVARAE DISDHLRLLL AAGSGTTDNH SGQPSIISTN
KALYPHFRDM MSKFSKLVIS SHIAAADWPN EDSAQKCIQE ADGVLLGVFS YVEVARQQRG
EEIPRLFPGF FIGSTIGGSW QNNGVGPRDP VAPSCPEDEE GSIEPTAILD SKLLDRLDEQ
KRILVSSIRE LDKSLIVPEK VISPLRHEVI GNNVCLAGSK VLETFKIWIA MIESIDLSHL
RTRHPNTQLE DFGINKQSLY DNVSDLILGC QAVAGPLADE WSEVRGESME SRLDYVKQCA
RSLETNSSHI GFSLQMLSDQ ITLNLLHQPR NPAPRPRENS LTRTTIQRGD TVAYDRPHQR
LESRPAASRP PLITAQSFSD GEPPPGHFRK GDYSKVKKIF GEDPSPQAGM QAGDDVPEYL
RLDFESDVSW ETKTTPHTVK GGSLIGLVEQ LTRHDKLDSS FNNTFLLTYR SFTTARELYE
LLVKRFGIQP PEGLSPSDYE LWRDQKQKLI RFRVVNILKS WFDVFWMEET NEESRQLIRD
VYSFTRDSVK SAETPGSGPL MAILDQRLNG KDVGSRRMIQ TVNQSTPTPI VPKNMKKLKF
LDVDVTEFAR QLTIVESRLY GKIKATECLS KTWQKKIAEG EPELAPNVKA LILHSNQMTN
WVAEMILAQI ELKKRVVVIK HFVAIADKCR ALNNYSTLTS IISALATAPI ARLKRTWDQV
PQRTQGVLES MRRVMASTKN FGEYREALHA ANPPCIPFFG VYLTDLTFIE DGIPSTIKKT
NLINFAKRAK TAEVIRDIQQ YQNVGYSLQS VPELQDYILS NMHSAGDVHE MYDRSLQVEP
REREDEKIVR YAL
//
