ID M1W9B9_CLAP2 Unreviewed; 992 AA.
AC M1W9B9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 13-SEP-2023, entry version 35.
DE RecName: Full=Cleavage and polyadenylation specificity factor subunit 2 {ECO:0000256|RuleBase:RU365006};
DE AltName: Full=Cleavage and polyadenylation specificity factor 100 kDa subunit {ECO:0000256|RuleBase:RU365006};
GN ORFNames=CPUR_03610 {ECO:0000313|EMBL:CCE29763.1};
OS Claviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Claviceps.
OX NCBI_TaxID=1111077 {ECO:0000313|EMBL:CCE29763.1, ECO:0000313|Proteomes:UP000016801};
RN [1] {ECO:0000313|EMBL:CCE29763.1, ECO:0000313|Proteomes:UP000016801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=20.1 {ECO:0000313|EMBL:CCE29763.1,
RC ECO:0000313|Proteomes:UP000016801};
RX PubMed=23468653; DOI=10.1371/journal.pgen.1003323;
RA Schardl C.L., Young C.A., Hesse U., Amyotte S.G., Andreeva K., Calie P.J.,
RA Fleetwood D.J., Haws D.C., Moore N., Oeser B., Panaccione D.G.,
RA Schweri K.K., Voisey C.R., Farman M.L., Jaromczyk J.W., Roe B.A.,
RA O'Sullivan D.M., Scott B., Tudzynski P., An Z., Arnaoudova E.G.,
RA Bullock C.T., Charlton N.D., Chen L., Cox M., Dinkins R.D., Florea S.,
RA Glenn A.E., Gordon A., Gueldener U., Harris D.R., Hollin W., Jaromczyk J.,
RA Johnson R.D., Khan A.K., Leistner E., Leuchtmann A., Li C., Liu J., Liu J.,
RA Liu M., Mace W., Machado C., Nagabhyru P., Pan J., Schmid J., Sugawara K.,
RA Steiner U., Takach J.E., Tanaka E., Webb J.S., Wilson E.V., Wiseman J.L.,
RA Yoshida R., Zeng Z.;
RT "Plant-symbiotic fungi as chemical engineers: Multi-genome analysis of the
RT Clavicipitaceae reveals dynamics of alkaloid loci.";
RL PLoS Genet. 9:E1003323-E1003323(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU365006}.
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
CC {ECO:0000256|RuleBase:RU365006}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCE29763.1}.
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DR EMBL; CAGA01000016; CCE29763.1; -; Genomic_DNA.
DR AlphaFoldDB; M1W9B9; -.
DR STRING; 1111077.M1W9B9; -.
DR VEuPathDB; FungiDB:CPUR_03610; -.
DR eggNOG; KOG1135; Eukaryota.
DR HOGENOM; CLU_002227_3_0_1; -.
DR OrthoDB; 198429at2759; -.
DR PhylomeDB; M1W9B9; -.
DR Proteomes; UP000016801; Unassembled WGS sequence.
DR GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006378; P:mRNA polyadenylation; IEA:InterPro.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR022712; Beta_Casp.
DR InterPro; IPR027075; CPSF2.
DR InterPro; IPR025069; Cpsf2_C.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR011108; RMMBL.
DR PANTHER; PTHR45922; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2; 1.
DR PANTHER; PTHR45922:SF1; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2; 1.
DR Pfam; PF10996; Beta-Casp; 1.
DR Pfam; PF13299; CPSF100_C; 1.
DR Pfam; PF16661; Lactamase_B_6; 1.
DR Pfam; PF07521; RMMBL; 1.
DR SMART; SM01027; Beta-Casp; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|RuleBase:RU365006};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365006};
KW Reference proteome {ECO:0000313|Proteomes:UP000016801};
KW RNA-binding {ECO:0000256|RuleBase:RU365006}.
FT DOMAIN 288..452
FT /note="Beta-Casp"
FT /evidence="ECO:0000259|SMART:SM01027"
FT REGION 518..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..661
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 992 AA; 106872 MW; FE2447BD7DE5F879 CRC64;
MFTFCPLQGA LSESTASQSL LELDGGVKIL VDLGWDETFD VGKLEELEKQ VPTLSLILLT
HATVSHLAAY VHCCKHVPLF TRIPAYATRP VIDLGRSLTQ DLYSSTPAAS TAIRQSSLSE
IAYAYTQTAA AAAQNLLLQS PTPDEIARYF TLIQPLKYSQ PHQPLPSPFS PPLNGLTITA
YNSGHTLGGT IWHIQHGLES IVYAVDWNQA RENVFAGAAW LGGAGGGGAE VIEQLRKPTA
LICSSRGAQK SAQSGSRIKR DEQMLDMIKT CVFKGGTVLI PVDSSARVLE LSYFLEHAWR
ADAAPGANEN TLRSTKLYLA GRNMSSTMRN ARSMLEWMDD NIVQEFEACA EGQRKANGAM
EKKEAGPFDF KFLRILERKA QIAKLVNQAS PAVGDGAPSS GGRVILASDT SLEWGFSKDV
LKGLAQGPNN LVILTDRPTL TNNGPPSIAR TLWEWWKERS DGVSVDQASS NGENVESVYA
GGRELVIREA TRQSLEGDEL AVYQQWLATQ RQLQATQQTG AAGSLDGPAD VVDDASSESS
SESEDEDGQQ QGKALTVSAT MGQASRKNVI LKDEDLGINV LIKRKGVYDF DSRGKKGRER
CFPVVIRRKR TDDFGELIRP EDYLRAEEKD EDNAEGGNVT AEDDKLGKKR KWDDVAKGSK
GPNKRGHNHN NNKPGTANVD DGAGAGSDKG GPAMLDDLDD VEEDTEPEEP TGPCKLVYKS
ETIQANLRIG FVDFSGLHDR RSLDMLIPLI QPRKLILVGG NQAETMSLAE DCRAALGTDG
NDRAIDVFTP GVGVWVDASV DTNAWVVKLA DSLVKKLKWQ NVRGLSIVTI SGQLLATSLN
DNARGEIPAA ADADEADDND ATPSKRQKMD AAAAAAALPS TALTHTASKD TILPVLDVMP
SNLVSAARTT AQPLHVGDLR LADLRRAMQG SGHGAEFRGE GILVIDGSVS VRKTAEGRIE
VESVGLPALG KRNTLYQVKK AIYENLAVVA GA
//
