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Database: UniProt
Entry: M1WC58_CLAP2
LinkDB: M1WC58_CLAP2
Original site: M1WC58_CLAP2 
ID   M1WC58_CLAP2            Unreviewed;       405 AA.
AC   M1WC58;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   10-APR-2019, entry version 25.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=CPUR_02347 {ECO:0000313|EMBL:CCE28659.1};
OS   Claviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC   Claviceps.
OX   NCBI_TaxID=1111077 {ECO:0000313|EMBL:CCE28659.1, ECO:0000313|Proteomes:UP000016801};
RN   [1] {ECO:0000313|EMBL:CCE28659.1, ECO:0000313|Proteomes:UP000016801}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=20.1 {ECO:0000313|EMBL:CCE28659.1,
RC   ECO:0000313|Proteomes:UP000016801};
RX   PubMed=23468653; DOI=10.1371/journal.pgen.1003323;
RA   Schardl C.L., Young C.A., Hesse U., Amyotte S.G., Andreeva K.,
RA   Calie P.J., Fleetwood D.J., Haws D.C., Moore N., Oeser B.,
RA   Panaccione D.G., Schweri K.K., Voisey C.R., Farman M.L.,
RA   Jaromczyk J.W., Roe B.A., O'Sullivan D.M., Scott B., Tudzynski P.,
RA   An Z., Arnaoudova E.G., Bullock C.T., Charlton N.D., Chen L., Cox M.,
RA   Dinkins R.D., Florea S., Glenn A.E., Gordon A., Gueldener U.,
RA   Harris D.R., Hollin W., Jaromczyk J., Johnson R.D., Khan A.K.,
RA   Leistner E., Leuchtmann A., Li C., Liu J., Liu J., Liu M., Mace W.,
RA   Machado C., Nagabhyru P., Pan J., Schmid J., Sugawara K., Steiner U.,
RA   Takach J.E., Tanaka E., Webb J.S., Wilson E.V., Wiseman J.L.,
RA   Yoshida R., Zeng Z.;
RT   "Plant-symbiotic fungi as chemical engineers: Multi-genome analysis of
RT   the Clavicipitaceae reveals dynamics of alkaloid loci.";
RL   PLoS Genet. 9:E1003323-E1003323(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CCE28659.1}.
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DR   EMBL; CAGA01000009; CCE28659.1; -; Genomic_DNA.
DR   STRING; 5111.M1WC58; -.
DR   EnsemblFungi; CCE28659; CCE28659; CPUR_02347.
DR   OrthoDB; 1034517at2759; -.
DR   Proteomes; UP000016801; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 2.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016801};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361}.
FT   DOMAIN       48    360       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   405 AA;  43732 MW;  3487CED53A0596E8 CRC64;
     MKANDQIMAG CKIPLLEPAT VKVALAADQT TQQHILRSRD DIRSILSSNG SDTRLMVIVG
     PCSIHDVDEA IEYASLLSNA AELHRHELFI VMRVYVEKPR STVGWKGLVH EPDYAAPTRP
     MSKTLKPFVS SSDRSSQPEL NKGVLLSRKV MLDVAQRGLP VATELLNPLL AQYFDDITSL
     GVIGARTTES QTHRELASSM PMPVGFKNGT DGSLKVATDA MTSASHSHTV VGFDDHGHMA
     YHMSAGNPDT FVILRGGSNG PNFDAEHVAS AHAELRRAGR TPAVVVDCSH GNSMKDYRNQ
     AAVAACLADQ IASGVPIKGV MIESNIHQGR QDVIEDAATG QRRAKYGVSI TDGCIGWQET
     LTIFGKLAAA VKIRQQKLGM AVVNTTLQVD CEKSRMTQQV TEIAV
//
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