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Database: UniProt
Entry: M1WTZ3_PSEP2
LinkDB: M1WTZ3_PSEP2
Original site: M1WTZ3_PSEP2 
ID   M1WTZ3_PSEP2            Unreviewed;       356 AA.
AC   M1WTZ3;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 61.
DE   RecName: Full=Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00015486, ECO:0000256|HAMAP-Rule:MF_00230};
DE            Short=NN:DBI PRT {ECO:0000256|HAMAP-Rule:MF_00230};
DE            EC=2.4.2.21 {ECO:0000256|ARBA:ARBA00011991, ECO:0000256|HAMAP-Rule:MF_00230};
DE   AltName: Full=N(1)-alpha-phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00030686, ECO:0000256|HAMAP-Rule:MF_00230};
GN   Name=cobT {ECO:0000256|HAMAP-Rule:MF_00230,
GN   ECO:0000313|EMBL:CCH50032.1};
GN   OrderedLocusNames=BN4_12799 {ECO:0000313|EMBL:CCH50032.1};
OS   Pseudodesulfovibrio piezophilus (strain DSM 21447 / JCM 15486 / C1TLV30)
OS   (Desulfovibrio piezophilus).
OC   Bacteria; Thermodesulfobacteriota; Desulfovibrionia; Desulfovibrionales;
OC   Desulfovibrionaceae.
OX   NCBI_TaxID=1322246 {ECO:0000313|EMBL:CCH50032.1, ECO:0000313|Proteomes:UP000011724};
RN   [1] {ECO:0000313|EMBL:CCH50032.1, ECO:0000313|Proteomes:UP000011724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10523 / SB164P1 {ECO:0000313|Proteomes:UP000011724};
RX   PubMed=23383081; DOI=10.1371/journal.pone.0055130;
RA   Pradel N., Ji B., Gimenez G., Talla E., Lenoble P., Garel M., Tamburini C.,
RA   Fourquet P., Lebrun R., Bertin P., Denis Y., Pophillat M., Barbe V.,
RA   Ollivier B., Dolla A.;
RT   "The first genomic and proteomic characterization of a deep-sea sulfate
RT   reducer: insights into the piezophilic lifestyle of Desulfovibrio
RT   piezophilus.";
RL   PLoS ONE 8:e55130-e55130(2013).
RN   [2] {ECO:0000313|Proteomes:UP000011724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10523 / SB164P1 {ECO:0000313|Proteomes:UP000011724};
RX   PubMed=23961312; DOI=10.4056/sigs.3777412;
RA   Finster K.W., Kjeldsen K.U., Kube M., Reinhardt R., Mussmann M., Amann R.,
RA   Schreiber L.;
RT   "Complete genome sequence of Desulfocapsa sulfexigens, a marine
RT   deltaproteobacterium specialized in disproportionating inorganic sulfur
RT   compounds.";
RL   Stand. Genomic Sci. 8:58-68(2013).
CC   -!- FUNCTION: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from
CC       nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
CC       {ECO:0000256|HAMAP-Rule:MF_00230}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide =
CC         alpha-ribazole 5'-phosphate + H(+) + nicotinate;
CC         Xref=Rhea:RHEA:11196, ChEBI:CHEBI:15378, ChEBI:CHEBI:15890,
CC         ChEBI:CHEBI:32544, ChEBI:CHEBI:57502, ChEBI:CHEBI:57918; EC=2.4.2.21;
CC         Evidence={ECO:0000256|ARBA:ARBA00001058, ECO:0000256|HAMAP-
CC         Rule:MF_00230};
CC   -!- PATHWAY: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-
CC       ribazole from 5,6-dimethylbenzimidazole: step 1/2.
CC       {ECO:0000256|ARBA:ARBA00005049, ECO:0000256|HAMAP-Rule:MF_00230}.
CC   -!- SIMILARITY: Belongs to the CobT family. {ECO:0000256|ARBA:ARBA00007110,
CC       ECO:0000256|HAMAP-Rule:MF_00230}.
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DR   EMBL; FO203427; CCH50032.1; -; Genomic_DNA.
DR   RefSeq; WP_015416074.1; NC_020409.1.
DR   AlphaFoldDB; M1WTZ3; -.
DR   STRING; 1322246.BN4_12799; -.
DR   KEGG; dpi:BN4_12799; -.
DR   PATRIC; fig|879567.3.peg.3005; -.
DR   eggNOG; COG2038; Bacteria.
DR   HOGENOM; CLU_002982_0_0_7; -.
DR   OMA; AWMRKCA; -.
DR   OrthoDB; 9781491at2; -.
DR   BioCyc; DPIE1322246:BN4_RS14065-MONOMER; -.
DR   UniPathway; UPA00061; UER00516.
DR   Proteomes; UP000011724; Chromosome.
DR   GO; GO:0008939; F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd02439; DMB-PRT_CobT; 1.
DR   Gene3D; 1.10.1610.10; -; 1.
DR   Gene3D; 3.40.50.10210; -; 1.
DR   HAMAP; MF_00230; CobT; 1.
DR   InterPro; IPR003200; Nict_dMeBzImd_PRibTrfase.
DR   InterPro; IPR017846; Nict_dMeBzImd_PRibTrfase_bact.
DR   InterPro; IPR023195; Nict_dMeBzImd_PRibTrfase_N.
DR   InterPro; IPR036087; Nict_dMeBzImd_PRibTrfase_sf.
DR   NCBIfam; TIGR03160; cobT_DBIPRT; 1.
DR   PANTHER; PTHR43463; NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE; 1.
DR   PANTHER; PTHR43463:SF1; NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE; 1.
DR   Pfam; PF02277; DBI_PRT; 1.
DR   SUPFAM; SSF52733; Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT); 1.
PE   3: Inferred from homology;
KW   Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573, ECO:0000256|HAMAP-
KW   Rule:MF_00230};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676, ECO:0000256|HAMAP-
KW   Rule:MF_00230}; Reference proteome {ECO:0000313|Proteomes:UP000011724};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_00230}.
FT   ACT_SITE        322
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00230"
SQ   SEQUENCE   356 AA;  36824 MW;  0E5E1F726FF0BAB0 CRC64;
     MQKEFDTAVA AIQPVDRSLT DKGQAHLDSL TKPQGSLGRL EDLALQLFLI QEGQALQADP
     MRIYTVAGDH GVNDEGVSLF PQEVTRQMIL NFLGGGAGIN VLAKTAGAQL YVVDAGSCGG
     GYDEHPNLIQ AKIAPGTANL AQGPAMTRDQ CLQALMLGID LADRAYADGV KILGTGDMGI
     SNTTPSTALY CAFLGLKPLE VTGPGTGLDS DAVGRKAEVV ARGLKVNRSA LESGDAVEIL
     AALGGLEIAT LAGLILGGAK NRQLVSVDGF ISTAAYAAAW KICPAVKDYC IISHASAEPG
     HAKAVSAMDL DPLLHLGFRL GEGTGAACAM YLVRSAVDMY NNMATFADAG VAEAHD
//
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