ID M1XNS2_NATM8 Unreviewed; 478 AA.
AC M1XNS2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:CCQ35601.1};
DE EC=1.2.1.3 {ECO:0000313|EMBL:CCQ35601.1};
GN Name=aldH2 {ECO:0000313|EMBL:CCQ35601.1};
GN OrderedLocusNames=Nmlp_1397 {ECO:0000313|EMBL:CCQ35601.1};
OS Natronomonas moolapensis (strain DSM 18674 / CECT 7526 / JCM 14361 /
OS 8.8.11).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Natronomonas.
OX NCBI_TaxID=268739 {ECO:0000313|EMBL:CCQ35601.1, ECO:0000313|Proteomes:UP000011867};
RN [1] {ECO:0000313|EMBL:CCQ35601.1, ECO:0000313|Proteomes:UP000011867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18674 / JCM 14361 / 8.8.11
RC {ECO:0000313|Proteomes:UP000011867};
RX PubMed=23516216; DOI=10.1128/genomeA.00095-13;
RA Dyall-Smith M.L., Pfeiffer F., Oberwinkler T., Klee K., Rampp M., Palm P.,
RA Gross K., Schuster S.C., Oesterhelt D.;
RT "Genome of the haloarchaeon Natronomonas moolapensis, a neutrophilic member
RT of a previously haloalkaliphilic genus.";
RL Genome Announc. 1:e0009513-e0009513(2013).
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR EMBL; HF582854; CCQ35601.1; -; Genomic_DNA.
DR RefSeq; WP_015408447.1; NC_020388.1.
DR AlphaFoldDB; M1XNS2; -.
DR STRING; 268739.Nmlp_1397; -.
DR GeneID; 14650684; -.
DR KEGG; nmo:Nmlp_1397; -.
DR eggNOG; arCOG01252; Archaea.
DR HOGENOM; CLU_005391_1_0_2; -.
DR OrthoDB; 6342at2157; -.
DR Proteomes; UP000011867; Chromosome.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR CDD; cd07078; ALDH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR42991; ALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR42991:SF1; ALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003345,
KW ECO:0000313|EMBL:CCQ35601.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011867}.
FT DOMAIN 18..476
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 255
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 478 AA; 50129 MW; F80603843BF05DA6 CRC64;
MATDSTLNHD ELYIEGRWTP TADRIDVTDL TDDTTFASVS AATPADAEDA LAAAQAAEVE
MRETTVVQRA EWVTAIADGI EARKAELADV IVREAGKPIS SARGEVDAAA ERFRRAAEEA
RSLKGEYIEG TTEGHEGWRA IVRHEPVGTA LCITPYNYPL STTALQVAPA LAAGNAVILK
PASKTPISAA ILAEIIVDAA DDLPEGAFGF VPGRASEIGD VLAGDDRIDA IAMTGSSGAG
KHVAGVSGMV ELHMELGGNA PAIVFPDADL EAASSAAASG SLKYAGQRCS AVSRVLVHED
AHDELVDRID AEMDGFEPGD LFDEETSLGP LISHEQAEWV EELVEDALDR GATLVRGGAR
SGRFFEPTLL ADVPQDARIV HEEQFGPVVA VTTFDDEAGA LEVANGGSLG LDAAVFTADY
DRAMRVADRL EVGGVRINGA PSHGLGDIPF GGTKDSGIGR EGIGYTIEAF LERKSIIL
//
