ID M1Z7U3_LEPMJ Unreviewed; 1306 AA.
AC M1Z7U3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN ORFNames=Lema_P125720.1 {ECO:0000313|EMBL:CCT61166.1};
OS Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)
OS (Blackleg fungus) (Phoma lingam).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Leptosphaeriaceae;
OC Plenodomus; Plenodomus lingam/Leptosphaeria maculans species complex.
OX NCBI_TaxID=985895 {ECO:0000313|EMBL:CCT61166.1, ECO:0000313|Proteomes:UP000002668};
RN [1] {ECO:0000313|EMBL:CCT61166.1, ECO:0000313|Proteomes:UP000002668}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8
RC {ECO:0000313|Proteomes:UP000002668};
RX PubMed=21326234; DOI=10.1038/ncomms1189;
RA Rouxel T., Grandaubert J., Hane J.K., Hoede C., van de Wouw A.P.,
RA Couloux A., Dominguez V., Anthouard V., Bally P., Bourras S.,
RA Cozijnsen A.J., Ciuffetti L.M., Degrave A., Dilmaghani A., Duret L.,
RA Fudal I., Goodwin S.B., Gout L., Glaser N., Linglin J., Kema G.H.J.,
RA Lapalu N., Lawrence C.B., May K., Meyer M., Ollivier B., Poulain J.,
RA Schoch C.L., Simon A., Spatafora J.W., Stachowiak A., Turgeon B.G.,
RA Tyler B.M., Vincent D., Weissenbach J., Amselem J., Quesneville H.,
RA Oliver R.P., Wincker P., Balesdent M.-H., Howlett B.J.;
RT "Effector diversification within compartments of the Leptosphaeria maculans
RT genome affected by Repeat-Induced Point mutations.";
RL Nat. Commun. 2:202-202(2011).
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000256|ARBA:ARBA00008842,
CC ECO:0000256|RuleBase:RU003844}.
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DR EMBL; FP929136; CCT61166.1; -; Genomic_DNA.
DR STRING; 985895.M1Z7U3; -.
DR InParanoid; M1Z7U3; -.
DR Proteomes; UP000002668; Genome.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13292; PH_Osh1p_Osh2p_yeast; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972:SF205; OXYSTEROL-BINDING PROTEIN; 1.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000002668};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT REPEAT 243..265
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 350..382
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 438..533
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 743..777
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1306 AA; 145149 MW; CC7CE64C49D70AA6 CRC64;
MEGQVQSHKR SKSGTVKNLL SRVSSKNDVT YPSSPVEAST STSINTNPNP NPNTNTNAST
NETSPPTSSA ASLNSQPTAH LASSSSQSHK SAVHHRSLSK KSAHLSMAAG PNVTMASLNT
TQDSLSPASA SHQHHHQASP SSSTPKASSI EQSVRLFRVF ESLRNGDTAA ISRAIRDQTA
PASAPSDGDD RRSSLQLPSA RTEGTSILHL AVQCAEVPVI EFVLSNATAT PDSPIDINGR
DRDGNTPLHL AATLGRAPVV RMLLDQPGIN DSMTNYSGHT PLDLARTPDI FQQLQLSRSI
FIDTNVKRIQ HMVASGDLEA LEKTLQDERI KSTLDINGGE FATDPIVIDA GGTLLHEAAK
KKDVKLAQLL LLNGADPFRR DRKGKLPQDY TKDDRTRAIL KRSPAAAAAQ RGIQEKTILA
GGQPGAAATD SGMGAKESRE MKGYLKKWTN YTTGYKLRWF VLEDGVLSYY KHQDDIGSAC
RGAVNMRIAK LYMDPQDKQR FEIQGKSSVK YHLKANHQVE AKRWYWALNN AIQWAKDEAR
EEERRATQDQ ETLKQAKMAQ IRQEGDSTSL TSSKMANSKS LAPVNTLGVP VPSVDNTSSR
TAVSLTEEPG STYEPSMNGQ ELGRRVSHMG TNTIAGDDED EEDDFADDSS SREVKPHSKD
AFNITAQSAK LQLDLLSSVS AALQIEKSRS PNLQISDPLM LQAFASYESA ISNLKGLLGD
LLRISRDRDA YWQYRLDREA NVRRMWEESM AQVAKEQEEL ENRMGESEQK RRKTKKALKE
FLEDFEMDAP EKDAGDGEEK FVEAAEEAEH QDEVTNKPKS ISKVKRKATF ADIAAEISES
ESENDDEFFD AIGAGEVEVV EMPTAAPAVD EKKDPASTED IFEQRYSEIA TAWAGYEDGP
RKKLAMDADN RPKISLWGIL KSMIGKDMSK MTLPVSFNEP TSLLQRVAED MEYTDLLDTA
AERSDSTERL LYVAAFAASE YASTIGRVAK PFNPLLAETY EYARPDKGYR FFIEQVSHHP
PIGAAYAESK KWDYYGESAV RSKFYGKSFE VNPLGTWFLR LRPTSEGGKE EMYTWKKVTS
SVVGIITGNP MIDNYGPMEI RNHTTGEVCH LDFKQRGWKA SSAFQVVGKV LDAKGHVCWS
IGGRWNDKIY ARYTPGYEDA DIERSAAAKS KHEDNKAFLV WQAHERPTGI PFNLTPFVIT
LNAIPDKLRP IVAPTDTRLR PDQRAMEDGE YDLAATEKNR VEEKQRATRR QREARGEEFV
PRWFTKSTCP TTGEEFWEFN HEYWKIRDKV ARGEAKWPDA GLEDIF
//
